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Limonoids from the roots of Trichilia sinensis and their cytotoxicities

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Abstract

Six new compounds (1–4, 8, 10), along with six known limonoids (5–7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including 1H NMR, 13C NMR, DEPT, HSQC, HMBC, 1H–1H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.

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Acknowledgements

This research was financially supported by the Special Fund for Agro-scientific Research in the Public Interest (201303117), Special Grant for Modernization of Traditional Chinese Medicine of Hainan Province (2015ZY04) and Key Research and Development Scheme of Hainan Province (ZDYF2016140).

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Authors and Affiliations

  1. Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, People’s Republic of China

    Shou-Bai Liu, Wen-Li Mei, Hui-Qin Chen, Jun Wang & Hao-Fu Dai

  2. Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, 571737, People’s Republic of China

    Shou-Bai Liu & Zhu-Nian Wang

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  1. Shou-Bai Liu
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  2. Wen-Li Mei
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  3. Hui-Qin Chen
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  4. Jun Wang
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  5. Zhu-Nian Wang
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  6. Hao-Fu Dai
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Correspondence to Zhu-Nian Wang or Hao-Fu Dai.

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Liu, SB., Mei, WL., Chen, HQ. et al. Limonoids from the roots of Trichilia sinensis and their cytotoxicities. Arch. Pharm. Res. 41, 1170–1177 (2018). https://doi.org/10.1007/s12272-017-0915-0

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  • DOI: https://doi.org/10.1007/s12272-017-0915-0

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