5 Result(s)
within
**ao-fu Dai
Life Sciences
-
Article
Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways
Aging leads to a progressive decline in cardiac function, increasing the risk of heart failure with preserved ejection fraction (HFpEF). This study elucidates the impact of α-Klotho, an anti-aging hormone, on ...
-
Article
Open AccessMetabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between oxidative stress, mitochondrial dysfunction, and metabolic derang...
-
Article
Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure
Inhibition of mammalian target of rapamycin complex I (mTORC1) by rapamycin improves cardiac function in both aging and heart failure. While the protective mechanisms are not fully understood in mammals, they ...
-
Article
Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality
Severe fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne infectious disease caused by a novel phlebovirus (SFTS virus, SFTSV), was listed among the top 10 priority infectious diseases by the ...
-
Article
Identification, characterization and expression analysis of genes involved in steroidal saponin biosynthesis in Dracaena cambodiana
Dracaena cambodiana is a traditional medicinal plant used for producing dragon’s blood. The plants and dragon’s blood of D. cambodiana contain a rich variety of steroidal saponins. However, littl...
