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  1. No Access

    Article

    Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways

    Aging leads to a progressive decline in cardiac function, increasing the risk of heart failure with preserved ejection fraction (HFpEF). This study elucidates the impact of α-Klotho, an anti-aging hormone, on ...

    Nastaran Daneshgar, Renny Lan, Michael Regnier, Samuel G. Mackintosh… in GeroScience (2024)

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    Article

    Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure

    Inhibition of mammalian target of rapamycin complex I (mTORC1) by rapamycin improves cardiac function in both aging and heart failure. While the protective mechanisms are not fully understood in mammals, they ...

    Dao-Fu Dai, Yonggang Liu, Nathan Basisty, Pabalu Karunadharma… in GeroScience (2019)