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  1. No Access

    Article

    Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and “long” inverse agonists

    A series of 6-substituted carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators were discovered through 6-position modification guided by insights from the crystallographic profiles ...

    Ming-cheng Yu, Feng Yang, **ao-yu Ding, Nan-nan Sun… in Acta Pharmacologica Sinica (2021)

  2. No Access

    Article

    Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2

    Rheumatoid arthritis patients can be prescribed a combination of immunosuppressive drug leflunomide (LEF) and the antiviral drug acyclovir to reduce the high risk of infection. Acyclovir is a substrate of orga...

    **ao-ying Liao, Qiang-qiang Deng, Li Han, Zhi-tao Wu… in Acta Pharmacologica Sinica (2020)

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    Article

    Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy

    Aescin, a natural mixture of triterpene saponins, has been reported to exert anticancer effect. Recent studies show that aescin increases intracellular reactive oxygen species (ROS) levels. However, whether th...

    Bin Li, Guo-liang Wu, Wei Dai, Gang Wang, Hao-yuan Su… in Acta Pharmacologica Sinica (2018)

  4. Article

    Effects of an Al3+- and Mg2+-containing antacid, ferrous sulfate, and calcium carbonate on the absorption of nemonoxacin (TG-873870) in healthy Chinese volunteers

    To evaluate the effects of an Al3+- and Mg2+-containing antacid, ferrous sulfate, and calcium carbonate on the absorption of nemonoxacin in healthy humans.

    Yi-fan Zhang, **ao-jian Dai, Ting Wang, **ao-yan Chen… in Acta Pharmacologica Sinica (2014)

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  5. Article

    Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels

    This study was conducted to test the selectivity of DC031050 on cardiac and neuronal potassium channels.

    ** Li, Hai-feng Sun, **-zheng Zhou, Chao-ying Ma… in Acta Pharmacologica Sinica (2012)

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  6. Article

    Establishment and characterization of a new drug surviving cell line Am1010, derived directly from muscle metastases of a human lung adenocarcinoma patient with multi-drug-resistance to cisplatin, taxol, and gefitinib

    To Characterize a new human lung cancer cell line Am1010, derived from drug-surviving cells (DSCs).

    Hui-ling Li, Si-ming **e, Liang Zhang, Cheng-jie Cai… in Acta Pharmacologica Sinica (2010)

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  7. Article

    Electrophysiological characterization of a novel Kv channel blocker N, N′-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesulfonamide found in virtual screening

    N,N′-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesulfonamide (OMBSA) is a hit compound with potent voltage-gated K+ (Kv) channel-blocking activities that was found while searching the MDL Avail...

    Zhao-bing Gao, Xue-qin Chen, Hua-liang Jiang, Hong Liu… in Acta Pharmacologica Sinica (2008)

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