478 Result(s)
within
**ao-Yu Lu
English
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Article
Open AccessMacrophage-derived exosomes promote telomere fragility and senescence in tubular epithelial cells by delivering miR-155
Chronic kidney disease (CKD) is highly prevalent worldwide, and its global burden is substantial and growing. CKD displays a number of features of accelerated senescence. Tubular cell senescence is a common bi...
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Open AccessPerformance of Microsoft Azure Kinect DK as a tool for estimating human body segment lengths
The Microsoft Kinect depth sensor, with its built-in software that automatically captures joint coordinates without markers, could be a potential tool for ergonomic studies. This study investigates the perform...
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Open AccessMeasurement of the distance between tumor micro-foci and gross tumor in rectal cancer pathological specimens: implication on margin distance of clinical target volume treated with high-dose radiotherapy for rectal cancer
To measure the micro-foci distance away from gross tumor and to provide reference to create the clinical target volume (CTV) margin for boost radiotherapy in rectal adenocarcinoma.
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Open AccessA Phase 3, Randomized, Controlled Trial Evaluating the Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Moderate COVID-19
Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon. This clinical study aimed to evaluate its antiviral efficacy of ropeginterferon alfa-2b against SARS-CoV-2 infection.
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Progress and challenges of electrolyte modulation in aqueous zinc-ion batteries
As a new type of green battery system, aqueous zinc-ion batteries (AZIBs) have gradually become a research hotspot due to their low cost, high safety, excellent stability, high theoretical capacity (820 mAh·g−1) ...
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Open AccessAuthor Correction: Conserved regulatory switches for the transition from natal down to juvenile feather in birds
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Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice
Urolithin A (UroA), a dietary phytochemical, is produced by gut bacteria from fruits rich in natural polyphenols ellagitannins (ETs). The efficiency of ETs metabolism to UroA in humans depends on gut microbiot...
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Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
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A prospective study of zanubrutinib, a Bruton tyrosine kinase inhibitor, in relapsed/refractory idiopathic multicentric Castleman disease
Relapsed and refractory (R/R) idiopathic multicentric Castleman disease (iMCD) is a clinical challenge with no standard treatment. In this preliminary clinical trial, we investigated the efficacy and safety pr...
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Prediction model for develo** neuropsychiatric systemic lupus erythematosus in lupus patients
This study aimed to construct a predictive model for assessing the risk of development of neuropsychiatric systemic lupus erythematosus (NPSLE) among patients with SLE based on clinical, laboratory, and meteor...
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Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes
The High Altitude Detection of Astronomical Radiation (HADAR) experiment, which was constructed in Tibet, China, combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity ...
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Open AccessConserved regulatory switches for the transition from natal down to juvenile feather in birds
The transition from natal downs for heat conservation to juvenile feathers for simple flight is a remarkable environmental adaptation process in avian evolution. However, the underlying epigenetic mechanism fo...
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Open AccessDeciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis
Fas-associated protein with death domain (FADD), procaspase-8, and cellular FLICE-inhibitory proteins (cFLIP) assemble through death-effector domains (DEDs), directing death receptor signaling towards cell sur...
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Open AccessSyndecan-4 is required for early-stage repair responses during zebrafish heart regeneration
The healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar. The affected cardiac tissue may lose its function permanently. In cont...
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Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer
The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for the treatment of prostate cancer. Herein, we report the identification, optimization, and evaluat...
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Open AccessInvestigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse
Aging is a physiological condition accomplished with persistent low-grade inflammation and metabolic disorders. FGF21 has been reported to act as a potent longevity determinant, involving inflammatory response...
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Open AccessUltrasound-guided stellate ganglion block benefits the postoperative recovery of patients undergoing laparoscopic colorectal surgery: a single-center, double-blinded, randomized controlled clinical trial
With the increasing prevalence of colorectal cancer (CRC), optimizing perioperative management is of paramount importance. This study investigates the potential of stellate ganglion block (SGB), known for its ...
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Open AccessA chromosome-level genome assembly of the spider mite Tetranychus piercei McGregor
Despite the rapid advances in sequencing technology, limited genomic resources are currently available for phytophagous spider mites, which include many important agricultural pests. One of these pests is Tetrany...
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Open AccessIdentification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unc...
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Open AccessMechanistic insight into the C1 product selectivity for the catalytic hydrogenation of CO2 over metal-doped graphene
The conversion of CO2 into fuels and valuable chemicals presents a viable path toward carbon neutrality. The aim of this study is to investigate the potential of metal-doped graphene catalysts in the reduction of...
