23 Result(s)

Article

Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation

Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin resistance and fatty liver disease. Here we show that high-fat diet (HFD) feeding causes mitochondrial fragmentation in ...

Wenmin **a, Preethi Veeragandham, Yu Cao, Yayun Xu, Torrey E. Rhyne… in Nature Metabolism (2024)

Article

Comparative and phylogenetic analysis of Chiloschista (Orchidaceae) species and DNA barcoding investigation based on plastid genomes

Chiloschista (Orchidaceae, Aeridinae) is an epiphytic leafless orchid that is mainly distributed in tropical or subtropical forest canopies. This rare and threatened orchid lacks molecular resources for phylogene...

Ding-Kun Liu, Cheng-Yuan Zhou, **ong-De Tu, Zhuang Zhao, **-Liao Chen… in BMC Genomics (2023)

Article

Neurokinin-1 receptor drives PKCɑ-AURKA/N-Myc signaling to facilitate the neuroendocrine progression of prostate cancer

The widespread application of antiandrogen therapies has aroused a significant increase in the incidence of NEPC, a lethal form of the disease lacking efficient clinical treatments. Here we identified a cell s...

**ao-Wei Zhang, **g-Yi Li, Lin Li, Wen-Qian Hu, Yan Tao… in Cell Death & Disease (2023)

Article

CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang… in Cell Discovery (2023)

Article

Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model

Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation. The connection between I/R-induced injury response and liver heterogeneity has yet to be fully understood. In this s...

Jiaqi **n, Ting Yang, **aoyi Wu, Yingting Wu, Yi Liu, Xuan Liu… in Communications Biology (2023)

Article

Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens current global Coronavirus (COVID-19) vaccine ...

Bingqing **a, **aoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang… in Cell Discovery (2023)

Article

Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex

Poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a substantial clinical challenge. In the present ...

Yu-Yi Chu, Mei-Kuang Chen, Yongkun Wei, Heng-Huan Lee, Weiya **a… in Nature Cancer (2022)

Article

Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury

Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection in many neurological disorde...

**-**a Hu, Wei-**g Ma, Li-Ying He, Cong-Hui Zhang, Cheng Zhang… in Cell Death & Disease (2022)

Article

m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer

LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive. Here, we obtained GC ti...

Jian-**an Lin, Ning-Zi Lian, You-**n Gao, Qiao-Ling Zheng… in Cell Death & Disease (2022)

Article

Correction: Smooth muscle 22 alpha protein inhibits VSMC foam cell formation by supporting normal LXRα signaling, ameliorating atherosclerosis

Dan-Dan Zhang, Yu Song, Peng Kong, **n Xu, Ya-Kun Gao… in Cell Death & Disease (2021)

Article

RvD1 accelerates the resolution of inflammation by promoting apoptosis of the recruited macrophages via the ALX/FasL-FasR/caspase-3 signaling pathway

The uncontrolled inflammatory response caused by a disorder in inflammation resolution is one of the reasons for acute respiratory distress syndrome (ARDS). The macrophage pool markedly expands when inflammato...

Shu-yang **ang, Yang Ye, Qian Yang, Hao- ran Xu, Chen-xi Shen… in Cell Death Discovery (2021)

Article

Smooth muscle 22 alpha protein inhibits VSMC foam cell formation by supporting normal LXRα signaling, ameliorating atherosclerosis

Vascular smooth muscle cells (VSMCs) are indispensable components in foam cell formation in atherosclerosis. However, the mechanism behind foam cell formation of VSMCs has not been addressed. We found a potent...

Dan-Dan Zhang, Yu Song, Peng Kong, **n Xu, Ya-Kun Gao… in Cell Death & Disease (2021)

Article

Genome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator

Crocodilians are diving reptiles that can hold their breath under water for long periods of time and are crepuscular animals with excellent sensory abilities. They comprise a sister lineage of birds and have n...

Qiu-Hong Wan, Sheng-Kai Pan, Li Hu, Ying Zhu, Peng-Wei Xu, **-Quan **a… in Cell Research (2013)

Article

PJS, a novel isocoumarin with hexahydropyrimidine ring from Bacillus subtilis PJS

Shao-Wei Liu, **g **, Chuan Chen, Jia-Meng Liu, **g-Yan Li… in The Journal of Antibiotics (2013)

Article

BMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause

The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats.

Jun-qi Guo, **a Gao, Zhi-jie Lin, Wei-zhen Wu, Liang-hu Huang… in BMC Cell Biology (2013)