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Article
Open AccessPancreatitis affects gut microbiota via metabolites and inflammatory cytokines: an exploratory two-step Mendelian randomisation study
Previous studies have observed relationships between pancreatitis and gut microbiota; however, specific changes in gut microbiota abundance and underlying mechanisms in pancreatitis remain unknown. Metabolites...
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Article
Open AccessInterannual variation in the East Asian summer monsoon-tropical Atlantic SST relationship modulated by the Interdecadal Pacific Oscillation
Tropical Atlantic (TA) SST variability can impact the East Asian summer monsoon (EASM). Here, we find that the interannual EASM–TA relationship exhibits an evident interdecadal variation modulated by the Inter...
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Article
Open AccessEffects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial
This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight < 1500 g (VLBWI) to provide an evidence-based medicine basis...
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Article
Open AccessDiacerein versus non-steroidal anti-inflammatory drugs in the treatment of knee osteoarthritis: a meta-analysis
Knee osteoarthritis (KOA) is a common musculoskeletal condition affecting millions of people worldwide and posing a significant challenge to clinicians and researchers. Emerging evidence suggests that the mult...
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Article
Open AccessPurinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model
Purinergic signalling adenosine and its A1 receptors have been demonstrated to get involved in the mechanism of acupuncture (needling therapy) analgesia. However, whether purinergic signalling would be respons...
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Article
Open AccessEfficient Visual Recognition: A Survey on Recent Advances and Brain-inspired Methodologies
Visual recognition is currently one of the most important and active research areas in computer vision, pattern recognition, and even the general field of artificial intelligence. It has great fundamental impo...
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Article
Open AccessMutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera
Odorant receptors (ORs) as odorant-gated ion channels play a crucial role in insect olfaction. They are formed by a heteromultimeric complex of the odorant receptor co-receptor (Orco) and a ligand-selective Or...
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Article
Open AccessMelatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability
Melatonin, a natural hormone secreted by the pineal gland, has been reported to exhibit antitumor properties through diverse mechanisms of action. However, the oncostatic function of melatonin on esophageal sq...
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Article
Open AccessClinical Features of Central Retinal Vein Occlusion in Young Patients
Retinal vein occlusion (RVO) is the second most common retinal vascular disease. Central RVO (CRVO), in which obstruction occurs posterior to the lamina cribrosa due to various causes, manifests with extensive...
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Article
Open AccessShort term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China
With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...
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Article
Open AccessGenomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...
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Article
Open AccessStereotactic EEG-guided radiofrequency thermocoagulation versus anterior temporal lobectomy for mesial temporal lobe epilepsy with hippocampal sclerosis: study protocol for a randomised controlled trial
In this report, we aim to describe the design for the randomised controlled trial of Stereotactic electroencephalogram (EEG)-guided Radiofrequency Thermocoagulation versus Anterior Temporal Lobectomy for Mesia...
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Article
Open AccessAdvances in Deep Learning Methods for Visual Tracking: Literature Review and Fundamentals
Recently, deep learning has achieved great success in visual tracking tasks, particularly in single-object tracking. This paper provides a comprehensive review of state-of-the-art single-object tracking algori...
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Article
Open AccessDeletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development
Skeletal development and maintenance are complex processes known to be coordinated by multiple genetic and epigenetic signaling pathways. However, the role of long non-coding RNAs (lncRNAs), a class of crucial...
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Article
Open AccessElectromagnetic radiation-based IC device identification and verification using deep learning
The electromagnetic radiation of electronic equipment carries information and can cause information leakage, which poses a serious threat to the security system; especially the information leakage caused by en...
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Article
Open AccessChemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version)
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the ...
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Open AccessMining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients
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Open AccessRegulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells
The small GTPase Ran is upregulated in multiple cancers and fundamental for cancer cell survival and progression, but its significance and molecular mechanisms in colorectal cancer (CRC) remain elusive.
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Article
Open AccessChinese herbal medicine Tangshen Formula treatment for type 2 diabetic kidney disease in the early stage: study protocol for a randomized controlled trial
Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease and has become a heavy economic and social burden due to its high prevalence and morbidity. The most effective strategy is that patie...
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Article
Open AccessAutomatic labeling of the fanning and curving shape of Meyer’s loop for epilepsy surgery: an atlas extracted from high-definition fiber tractography
Visual field defects caused by injury to Meyer’s loop (ML) are common in patients undergoing anterior temporal lobectomy during epilepsy surgery. Evaluation of the anatomical shapes of the curving, fanning and...
