7 Result(s)
within
**ao-Tong Fan
Life Sciences
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Article
Open AccessPancreatitis affects gut microbiota via metabolites and inflammatory cytokines: an exploratory two-step Mendelian randomisation study
Previous studies have observed relationships between pancreatitis and gut microbiota; however, specific changes in gut microbiota abundance and underlying mechanisms in pancreatitis remain unknown. Metabolites...
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Article
Open AccessMutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera
Odorant receptors (ORs) as odorant-gated ion channels play a crucial role in insect olfaction. They are formed by a heteromultimeric complex of the odorant receptor co-receptor (Orco) and a ligand-selective Or...
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Article
A single gene integrates sex and hormone regulators into sexual attractiveness
Sex differentiation and hormones are essential for the development of sexual signals in animals, and the regulation of sexual signals involves complex gene networks. However, it is unknown whether a core gene ...
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Article
Open AccessDeletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development
Skeletal development and maintenance are complex processes known to be coordinated by multiple genetic and epigenetic signaling pathways. However, the role of long non-coding RNAs (lncRNAs), a class of crucial...
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Article
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1
The sympathetic nervous system–catecholamine–uncoupling protein 1 (UCP1) axis plays an essential role in non-shivering adaptive thermogenesis. However, whether there exists a direct effector that physically co...
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Article
Open AccessMining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients
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Article
Open AccessThe balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
Reproducibility is a fundamental requirement in scientific experiments. Some recent publications have claimed that microarrays are unreliable because lists of differentially expressed genes (DEGs) are not repr...
