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  1. No Access

    Article

    Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer

    The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for the treatment of prostate cancer. Herein, we report the identification, optimization, and evaluat...

    **-shan Wu, **ao-yu Luo, Cheng-chang Li, **ao-fan Zhao in Acta Pharmacologica Sinica (2024)

  2. Article

    Open Access

    Pancreatitis affects gut microbiota via metabolites and inflammatory cytokines: an exploratory two-step Mendelian randomisation study

    Previous studies have observed relationships between pancreatitis and gut microbiota; however, specific changes in gut microbiota abundance and underlying mechanisms in pancreatitis remain unknown. Metabolites...

    Yi-Fan Qiu, Jun Ye, **-** **e, **ao-Tong Mao in Molecular Genetics and Genomics (2024)

  3. No Access

    Article

    East Asian summer monsoon response to anthropogenic aerosols redistribution: contrasting 1950–1980 and 1980–2010 to understand the role of non-Asian forcing

    Anthropogenic aerosols (AA) induce pronounced East Asian summer monsoon (EASM) changes since the industrial revolution. However, the regional contribution from different AA emission sources is hard to quantify...

    Zhinan Shao, Hai Wang, Yu-Fan Geng, Chenrui Diao, Yangyang Xu in Climate Dynamics (2024)

  4. No Access

    Article

    Arterial chemotherapy for hepatocellular carcinoma in China: consensus recommendations

    Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third leading cause of cancer-related deaths globally. Hepatic arterial infusion chemotherapy (HAIC) treatment is widely accepted a...

    Ming Zhao, Zhi Guo, Ying-Hua Zou, **ao Li, Zhi-** Yan in Hepatology International (2024)

  5. No Access

    Book and Conference Proceedings

    Computer Supported Cooperative Work and Social Computing

    18th CCF Conference, ChineseCSCW 2023, Harbin, China, August 18–20, 2023, Revised Selected Papers, Part I

    Yuqing Sun, Tun Lu, Tong Wang in Communications in Computer and Information Science (2024)

  6. No Access

    Book and Conference Proceedings

    Computer Supported Cooperative Work and Social Computing

    18th CCF Conference, ChineseCSCW 2023, Harbin, China, August 18–20, 2023, Revised Selected Papers, Part II

    Yuqing Sun, Tun Lu, Tong Wang in Communications in Computer and Information Science (2024)

  7. No Access

    Article

    Purification with macroporous resin and antioxidant activity of polyphenols from sweet potato leaves

    In this study, polyphenols from sweet potato leaves were purified by macroporous resin, and antioxidant activity was evaluated by free radical scavenging. AB-8, D-101, HPD-100 and DM301 four resins were select...

    Li-Feng Yang, Wei Nie, Yan-** Cui, Feng-Li Yue, **ao-Tong Fan in Chemical Papers (2024)

  8. Article

    Open Access

    Interannual variation in the East Asian summer monsoon-tropical Atlantic SST relationship modulated by the Interdecadal Pacific Oscillation

    Tropical Atlantic (TA) SST variability can impact the East Asian summer monsoon (EASM). Here, we find that the interannual EASM–TA relationship exhibits an evident interdecadal variation modulated by the Inter...

    Hao Wang, Ziguang Li, Jian** Li, **aopei Lin in npj Climate and Atmospheric Science (2023)

  9. Article

    Open Access

    Effects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial

    This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight < 1500 g (VLBWI) to provide an evidence-based medicine basis...

    Qing Yang, Juan Kong, Rui-Miao Bai, Wen-Ting Yu in European Journal of Clinical Nutrition (2023)

  10. Article

    Open Access

    Diacerein versus non-steroidal anti-inflammatory drugs in the treatment of knee osteoarthritis: a meta-analysis

    Knee osteoarthritis (KOA) is a common musculoskeletal condition affecting millions of people worldwide and posing a significant challenge to clinicians and researchers. Emerging evidence suggests that the mult...

    Fan Zeng, Kang Wang, Hang Duan, **ao-tong Xu in Journal of Orthopaedic Surgery and Research (2023)

  11. Article

    Open Access

    Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model

    Purinergic signalling adenosine and its A1 receptors have been demonstrated to get involved in the mechanism of acupuncture (needling therapy) analgesia. However, whether purinergic signalling would be respons...

    Hai-Yan Yin, Ya-Peng Fan, Juan Liu, Dao-Tong Li, **g Guo in Purinergic Signalling (2023)

  12. Article

    Open Access

    Efficient Visual Recognition: A Survey on Recent Advances and Brain-inspired Methodologies

    Visual recognition is currently one of the most important and active research areas in computer vision, pattern recognition, and even the general field of artificial intelligence. It has great fundamental impo...

    Yang Wu, Ding-Heng Wang, **ao-Tong Lu, Fan Yang, Man Yao in Machine Intelligence Research (2022)

  13. No Access

    Article

    Rational design of heterostructured core–shell Co-Zn bimetallic selenides for improved sodium-ion storage

    Bimetallic selenide with core–shell structure (CoSe2/ZnSe/NC@ZnSe/NC) has been successfully prepared through facile carbonization and selenization processes of its core–shell metal–organic framework precursors, i...

    Hua-Jian Liang, **ao-Tong Li, Wen-Zhi Zheng, Zhi-Ting Liu, Wei Yang in Rare Metals (2022)

  14. Article

    Open Access

    Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera

    Odorant receptors (ORs) as odorant-gated ion channels play a crucial role in insect olfaction. They are formed by a heteromultimeric complex of the odorant receptor co-receptor (Orco) and a ligand-selective Or...

    **ao-Bin Fan, Bao-Tong Mo, Guo-Cheng Li, Ling-Qiao Huang, Hao Guo in BMC Biology (2022)

  15. Article

    Open Access

    Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability

    Melatonin, a natural hormone secreted by the pineal gland, has been reported to exhibit antitumor properties through diverse mechanisms of action. However, the oncostatic function of melatonin on esophageal sq...

    Zhi-Qiang Ma, Ying-Tong Feng, Kai Guo, Dong Liu in Military Medical Research (2022)

  16. No Access

    Article

    A single gene integrates sex and hormone regulators into sexual attractiveness

    Sex differentiation and hormones are essential for the development of sexual signals in animals, and the regulation of sexual signals involves complex gene networks. However, it is unknown whether a core gene ...

    Nan Chen, Yong-Jun Liu, Yong-Liang Fan, **ao-** Pei in Nature Ecology & Evolution (2022)

  17. Article

    Open Access

    Clinical Features of Central Retinal Vein Occlusion in Young Patients

    Retinal vein occlusion (RVO) is the second most common retinal vascular disease. Central RVO (CRVO), in which obstruction occurs posterior to the lamina cribrosa due to various causes, manifests with extensive...

    **ao-Tong Zhang, Yi-Fan Zhong, Yan-Qi Xue, Si-Qi Li in Ophthalmology and Therapy (2022)

  18. Article

    Open Access

    Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China

    With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...

    Chun-Hong Jia, Zhou-Shan Feng, **ao-Jun Lin, Qi-Liang Cui in Scientific Reports (2022)

  19. No Access

    Article

    Delineating the Decussating Dentato-rubro-thalamic Tract and Its Connections in Humans Using Diffusion Spectrum Imaging Techniques

    The objective of this study was to identify the decussating dentato-rubro-thalamic tract (d-DRTT) and its afferent and efferent connections in healthy humans using diffusion spectrum imaging (DSI) techniques. ...

    Si-Qi Ou, Peng-Hu Wei, **ao-Tong Fan, Yi-He Wang, Fei Meng, Mu-Yang Li in The Cerebellum (2022)

  20. No Access

    Article

    Investigation of Antibiotic-Resistant Bacterial Communities and Antibiotic-Resistant Genes in Wastewater Treatment Plants: Removal of Antibiotic-Resistant Genes by the BBR Process

    The antibiotic-resistant bacteria (ARB) and antibiotic-resistant genes (ARGs) in Wastewater treatment plants (WWTPs) have attracted increasing attention. In this study, the abundance of ARB and resistance genes t...

    Zi-fan Weng, Yu-qin He, Guo-xiang Li in Bulletin of Environmental Contamination an… (2022)

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