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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
Open AccessTumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling
Whether stem-cell-like cancer cells avert ferroptosis to mediate therapy resistance remains unclear. In this study, using a soft fibrin gel culture system, we found that tumor-repopulating cells (TRCs) with st...
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Article
Results and analysis of examination doses for paediatric CT procedures based on a nationwide survey in China
To report the results of a dose survey conducted across 31 provinces in mainland China from 2017 to 2018 and to analyse the dose level to determine the national diagnostic reference levels (DRLs) for paediatri...
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Article
Optimization mechanism of matrix microstructure evolution on strength-plasticity of Mg/Al composite plate during hard-plate accumulative roll bonding
Mg/Al composite plate combines the light weight of Mg alloy and the plasticity and corrosion resistance of Al alloy, which significantly enhances its comprehensive performance. However, the long manufacturing ...
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Article
Open AccessThe transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3
The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process an...
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Article
Open AccessLaparoscopic versus open distal gastrectomy for advanced gastric cancer in elderly patients: a propensity-score matched analysis
Scarce research has reported the efficacy and safety of laparoscopic distal gastrectomy in elderly patients. This retrospective study aimed to compare the outcomes of laparoscopic and open distal gastrectomy f...
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Article
Open AccessBuilding bridges of excellence: a comprehensive competence framework for nurses in hospice and palliative care—a mixed method study
Hospice and Palliative Care (HPC) is in high demand in China; however, the country is facing the shortage of qualified HPC nurses. A well-suited competence framework is needed to promote HPC human resource dev...
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Article
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles
Liver fibrosis is a wound-healing process characterized by excess formation of extracellular matrix (ECM) from activated hepatic stellate cells (HSCs). Previous studies show that both EZH2, an epigenetic regul...
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Article
Comparison of robotic‑assisted versus conventional laparoscopic surgery for mid–low rectal cancer: a systematic review and meta-analysis
Scarce research has reported the comparison between robotic and laparoscopic surgery in mid–low rectal cancer. Therefore, this meta-analysis is aimed to compare the safety and efficacy of the two surgical appr...
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Article
Comparison of intracorporeal and extracorporeal anastomosis in left hemicolectomy: updated meta-analysis of retrospective control trials
The feasibility and effectiveness of selecting an intracorporeal or extracorporeal technique in left hemicolectomy remain poorly understood. This meta-analysis aimed to evaluate the difference between the two ...
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Article
Open AccessMacrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis
Schistosoma parasites, causing schistosomiasis, exhibit typical host specificity in host preference. Many mammals, including humans, are susceptible to infection, while the widely distributed rodent, Microtus for...
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Article
Robotic-assisted intracorporeal versus extracorporeal techniques in sigmoidectomy: a propensity score-matched analysis
Scarce research has been performed to assess the safety and efficacy of anastomosis technique on robotic-assisted sigmoidectomy. This study was designed to evaluate the difference between intracorporeal and ex...
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Article
Astrocyte-Neuronal Communication and Its Role in Stroke
Astrocytes are the most abundant glial cells in the central nervous system. These cells are an important hub for intercellular communication. They participate in various pathophysiological processes, including...
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Article
Aurantio-obtusin ameliorates obesity by activating PPARα-dependent mitochondrial thermogenesis in brown adipose tissues
Obesity contributes to the progression of various chronic diseases, and shortens life expectancy. With abundant mitochondria, brown adipose tissue (BAT) dissipates energy through heat to limit weight gain and ...
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Article
Efficacy of Biejiajian Pill on Intestinal Microbiota in Patients with Hepatitis B Cirrhosis/Liver Fibrosis: A Randomized Double-Blind Controlled Trial
To analyze the efficacy of Biejiajian Pill (BJJP) on intestinal microbiota in patients with hepatitis B cirrhosis/liver fibrosis, and explore its relationship with liver fibrosis.
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Article
Environmentally friendly expanded graphite-doped ZnO superhydrophobic coating with good corrosion resistance in marine environment
Designing and fabricating the marine anti-corrosion materials without fluorine by superhydrophobic method is a huge challenge. In this study, an environmentally friendly composite coating was prepared by combi...
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Article
First-line pyrotinib in advanced HER2-mutant non-small-cell lung cancer: a patient-centric phase 2 trial
To explore targeted treatment options in patients with non-small-cell lung cancer (NSCLC) with rare genetic mutations in the context of a patient-centric clinical trial, we initiated, in parallel, a phase 2 ad...
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Article
Open AccessJoint optic disc and cup segmentation based on multi-scale feature analysis and attention pyramid architecture for glaucoma screening
Automatic segmentation of optic disc (OD) and optic cup (OC) is an essential task for analysing colour fundus images. In clinical practice, accurate OD and OC segmentation assist ophthalmologists in diagnosing...
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Article
Retraction Note: Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma
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Article
Open AccessThe regulatory role and mechanism of lncTUG1 on cartilage apoptosis and inflammation in osteoarthritis
Long-stranded non-coding RNA TUG1 is lowly expressed in osteoarthritic chondrocytes. This study aimed to elucidate the role of TUG1 in osteoarthritic cartilage damage and the underlying mechanisms.
