45 Result(s)
within
**ao-Long Yan
Life Sciences
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Article
Chymase induces profibrotic response via transforming growth factor-β1/Smad activation in rat cardiac fibroblasts
Mast cell-derived chymase is implicated in myocardial fibrosis (MF), but the underlying mechanism of intracellular signaling remains unclear. Transforming growth factor-β1 (TGF-β1) is identified as the most im...
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Involvement of ERK and AKT signaling in the growth effect of arginine vasopressin on adult rat cardiac fibroblast and the modulation by simvastatin
Arginine vasopressin (AVP) has been shown to directly induce neonatal rat cardiac fibroblasts (CFs) proliferation, a major component involved in cardiac hypertrophy. Herein, we explored whether AVP is also a g...
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Velleratretraol, an unusual highly functionalized lactarane sesquiterpene from Lactarius vellereus
An unusual highly functionalized lactarane sesquiterpene, named velleratretraol (1), was isolated from the ethanol extract of the fruiting body of the mushroom Lactarius vellereus. Its structure was determined th...
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Novel 1-alkyl-tryptophan derivatives downregulate IDO1 and IDO2 mRNA expression induced by interferon-gamma in dendritic cells
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of im...
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Development and characterization of twelve polymorphic microsatellite loci for the Chinese concave-eared frog (Odorrana tormota)
The Chinese concave-eared frog is a rare species endemic to a restricted region of easternChina. In the present study, we isolated twelve polymorphic microsatellite loci from a dinucleotide—or trinucleotide—en...
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Molecular tagging of a stripe rust resistance gene in Aegilops tauschii
Stripe rust, caused by Puccinia striiformis f. sp. tritici (PST), is one of the most important diseases of common wheat (Triticum aestivum L.). China has the largest stripe rust epidemic areas in the world and yi...
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Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae
Three new phthalide derivatives (1-3) named 5-(3′-methyl-2′-butenyl)-2-hydroxy-3-methoxy-4-methylbenzoic acid (1), 5-(3′-carboxyl-3′-methyl-2E-allyloxy)-3-methoxy-4-methylphthalide (2) and 5-(3′,3′-dimethylallylo...
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Open AccessGenetic map of Triticum turgidumbased on a hexaploid wheat population without genetic recombination for D genome
A synthetic doubled-haploid hexaploid wheat population, SynDH1, derived from the spontaneous chromosome doubling of triploid F1 hybrid plants obtained from the cross of hybrids Triticum turgidum ssp. durum line L...
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Novel and ancient HMW glutenin genes from Aegilops tauschii and their phylogenetic positions
A pair of novel high-molecular-weight glutenin subunits (HMW-GS) 1Dx3.1t and 1Dy11*t were revealed and characterized from Aegilops tauschii Coss. subspecies tauschii accession AS60. SDS-PAGE band of 1Dx3.1t was b...
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Open AccessEffect of different dietary omega-3/omega-6 fatty acid ratios on reproduction in male rats
Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the reproduction of male animals are widely described in the literature. However, there is little information about the effect of n-3/n-...
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Detecting protein complexes based on relevancy from protein interaction networks
In protein-protein interaction networks, proteins combine into macromolecular complexes to execute essential functions in the cells, such as replication, transcription, protein transport. To solve the problem ...
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Open AccessComparative transcriptome analysis of tomato (Solanum lycopersicum) in response to exogenous abscisic acid
Abscisic acid (ABA) can regulate the expressions of many stress-responsive genes in plants. However, in defense responses to pathogens, mounting evidence suggests that ABA plays variable roles. Little informat...
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Anatomic Structure and Expression Profiles of Related Genes: Novel Insights into Leaf Development in Celery
Celery (Apium graveolens L.) belongs to the Apiaceae family and biennial herbs. Celery is an important vegetable that is cultivated and consumed worldwide. Celery leaves, particularly the petioles, are the main e...
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Fungal diversity notes 111–252—taxonomic and phylogenetic contributions to fungal taxa
This paper is a compilation of notes on 142 fungal taxa, including five new families, 20 new genera, and 100 new species, representing a wide taxonomic and geographic range. The new families, Ascocylindricaceae,
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Open AccessVertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain...
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Open AccessIdentification of single nucleotide polymorphism markers associated with resistance to bruchids (Callosobruchus spp.) in wild mungbean (Vigna radiata var. sublobata) and cultivated V. radiata through genoty** by sequencing and quantitative trait locus analysis
Bruchid beetles are an important storage pest of grain legumes. Callosobruchus sp. infect mungbean (Vigna radiata) at low levels in the field, multiply during grain storage and can destroy seed stocks in a few mo...
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Fungal diversity notes 367–490: taxonomic and phylogenetic contributions to fungal taxa
This is a continuity of a series of taxonomic papers where materials are examined, described and novel combinations are proposed where necessary to improve our traditional species concepts and provide updates ...
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Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer
The zinc-finger transcription factor Snail1 is inappropriately expressed in breast cancer and associated with poor prognosis. While interrogating human databases, we uncovered marked decreases in relapse-free ...
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Open AccessExtrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation
Intracellular accumulation of the hyperphosphorylated tau is a pathological hallmark in the brain of Alzheimer disease. Activation of extrasynaptic NMDA receptors (E-NMDARs) induces excitatory toxicity that is...
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Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring
Tree shrews have a close relationship to primates and have many advantages over rodents in biomedical research. However, the lack of gene manipulation methods has hindered the wider use of this animal. Spermat...
