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Article
Preparation of (S)-epichlorohydrin using a novel halohydrin dehalogenase by selective conformation adjustment
Chiral epichlorohydrin (ECH) is an attractive intermediate for chiral pharmaceuticals and chemicals preparation. The asymmetric synthesis of chiral ECH using 1,3-dicholoro-2-propanol (1,3-DCP) catalyzed by a h...
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Article
Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families
To examine the clinical phenotype and genetic deficiencies present in Chinese aniridia families with PAX6 haplotype deficiency.
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Article
CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells
Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for imaging genomes, in particular non-repetitive DNAs, are limited. We developed CRISPRdelight, a DNA-labeling system base...
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Article
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65−/−) mice exhibit a...
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Article
Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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Article
Open AccessCommon dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice
Dietary emulsifiers are linked to various diseases. The recent discovery of the role of gut microbiota–host interactions on health and disease warrants the safety reassessment of dietary emulsifiers through th...
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Article
Application of nanoscale metal–organic frameworks in tumor immunotherapy
Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence. However, due to the poor efficacy of the monotherapy in tumor immunotherapy, c...
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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
Open AccessAdipocyte pyroptosis occurs in omental tumor microenvironment and is associated with chemoresistance of ovarian cancer
Ovarian carcinoma (OC) is a fatal malignancy, with most patients experiencing recurrence and resistance to chemotherapy. In contrast to hematogenous metastasizing tumors, ovarian cancer cells disseminate withi...
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Article
Visualizing the structural evolution of individual active sites in MoS2 during electrocatalytic hydrogen evolution reaction
Understanding the structural evolution of individual active sites during a reaction is a long-standing target in surface science and catalysis. It is still challenging to precisely characterize in situ the int...
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Article
Neutralization of CX3CL1 Attenuates TGF-β-Induced Fibroblast Differentiation Through NF-κB Activation and Mitochondrial Dysfunction in Airway Fibrosis
Severe asthma, characterized by inflammation and airway remodeling, involves fibroblast differentiation into myofibroblasts expressing α-SMA. This process leads to the production of fibronectin and connective ...
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Article
Open AccessVirtual reality-based simulation learning on geriatric oral health care for nursing students: a pilot study
There is a great need for training and education in the nursing curriculum to improve nurses’ knowledge and skills to provide oral health care.
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Article
Open AccessA novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc
Gastric cancer (GC) ranks fifth in global cancer incidence and third in mortality rate among all cancer types. Circular RNAs (circRNAs) have been extensively demonstrated to regulate multiple malignant biologi...
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Article
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence
Renal tubular epithelial cell senescence plays a critical role in promoting and accelerating kidney aging and age-related renal fibrosis. Senescent cells not only lose their self-repair ability, but also can t...
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Article
Open AccessP. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study a...
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Article
Air permeability variation of compacted loess: effects of soil basic properties and dry-wet cycles
Loess, featured by its low permeability and cost-effectiveness, has become an increasingly popular material for landfill cover systems. However, the occurrence of cracks in loess caused by rainfall and evapora...
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Article
Analysis of related factors influencing postoperative recurrence of adenomyosis treated with HIFU
To analyze the efficacy of high-intensity focused ultrasound (HIFU) for adenomyosis and postoperative recurrence and its influencing factors.
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Article
Influence of oxygen-rich hot air composite gas medium on sintering performance and function mechanism
Hot air sintering technology is used to improve the quality and production efficiency of sintered ore. However, the current thick layer condition highlights the disadvantage of the low oxygen potential of the ...
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Article
ZnO/ZnS heterostructure in N-doped porous carbon for anchoring–diffusion–conversion of polysulfides for high-performance lithium–sulfur batteries
The shuttle effect of polysulfides is one of the key factors hindering the commercialization of lithium–sulfur batteries (LSBs). Owing to their high conductivity and advantageous structure, heterostructures ca...
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Article
Open AccessMouse serum albumin induces neuronal apoptosis and tauopathies
The elderly frequently present impaired blood–brain barrier which is closely associated with various neurodegenerative diseases. However, how the albumin, the most abundant protein in the plasma, leaking throu...
