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Article
Salvage haploidentical transplantation for graft failure after first haploidentical allogeneic stem cell transplantation: an updated experience
Graft failure is a fatal complication following allogeneic stem cell transplantation where a second transplantation is usually required for salvage. However, there are no recommended regimens for second transp...
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Article
First-principles study on the diffusion behavior of Cs and I in Cr coating
Cs and I can migrate through fuel-cladding interfaces and accelerate the cladding corrosion process induced by the fuel-cladding chemical interaction. Cr coating has emerged as an important candidate for mitig...
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Article
Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
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Article
Inflammation-related molecular signatures involved in the anticancer activities of brigatinib as well as the prognosis of EML4-ALK lung adenocarcinoma patient
Although ALK tyrosine kinase inhibitors (ALK-TKIs) have shown remarkable benefits in EML4-ALK positive NSCLC patients compared to conventional chemotherapy, the optimal sequence of ALK-TKIs treatment remains u...
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Article
Open AccessA novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc
Gastric cancer (GC) ranks fifth in global cancer incidence and third in mortality rate among all cancer types. Circular RNAs (circRNAs) have been extensively demonstrated to regulate multiple malignant biologi...
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Article
Open AccessOsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate
The chromatin modifier GRAIN WEIGHT 6a (GW6a) enhances rice grain size and yield. However, little is known about its gene network determining grain size. Here, we report that MITOGEN-ACTIVED PROTEIN KINASE 6 (...
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Article
Open AccessStudy on energy evolution and fractal characteristics of sandstone with different fracture dip angles under uniaxial compression
In order to investigate the failure modes and instability mechanism of fractured rock. Uniaxial compression tests were conducted on sandstone specimens with different dip angles. Based on rock energy dissipati...
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Article
Metamorphic P–T conditions and ages of garnet-biotite schists in the Dahongshan Group from the southwestern Yangtze Block
The Dahongshan Group, situated at the southwestern margin of the Yangtze Block, represents a geological unit characterized by relatively high-grade metamorphism in the region. This paper investigates the garne...
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Article
Open AccessNADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated. In this study, we te...
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Article
Open AccessReorganization of intrinsic functional connectivity in early-stage Parkinson’s disease patients with probable REM sleep behavior disorder
REM sleep behavior disorder (RBD) symptoms in Parkinson’s disease (PD) suggest both a clinically and pathologically malignant subtype. However, whether RBD symptoms are associated with alterations in the organ...
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Article
Open AccessGDF11 slows excitatory neuronal senescence and brain ageing by repressing p21
As a major neuron type in the brain, the excitatory neuron (EN) regulates the lifespan in C. elegans. How the EN acquires senescence, however, is unknown. Here, we show that growth differentiation factor 11 (G...
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Article
Open AccessNULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing
The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range of the plasma proteome. Here we addres...
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Article
Review of the development status of rock burst disaster prevention system in China
Deep-land resource exploitation is a crucial focus of future scientific and technological development in China. However, with the increasing depth of coal mining, rock burst disasters occur frequently, posing ...
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Article
Grinding Contribution and Quantitative Separation of Impact and Grinding Mechanism in Cylindrical Mill
Optimizing and adjusting the particle size composition of grinding products is of great significance for improving economic benefits and resource recovery and utilization. In this study, grinding contribution ...
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Article
Superior Pitting Corrosion Resistance of Ultra-high Strength Low Alloy Steel Via Co-alloying Al and Cu
Advanced high-strength low alloy (HSLA) steels with outstanding corrosion resistance are extensively applied in marine engineering. However, corrosion sensitivity increases with steel strength. In this study, ...
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Article
Open AccessA multicenter prospective study on the management of hepatoblastoma in children: a report from the Chinese Children’s Cancer Group
This study aimed to identify survival risk factors in Chinese children with hepatoblastoma (HB) and assess the effectiveness of the new treatment protocol proposed by the Chinese Children’s Cancer Group (CCCG)...
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Article
Experimental investigation on mechanical behaviors and microstructure responses of the coking coal subjected to freeze-thaw cycles
In this paper, the uniaxial compression test of coking coal with different freeze-thaw (F-T) cycles was carried out, accompanied by the monitoring of the acoustic emission (AE) system and digital image correla...
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Article
Open AccessCACA guidelines for holistic integrative management of nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor originating in the nasopharynx and is particularly prevalent in southern China. Unfortunately, international guidelines, such as NCCN or ESMO, fai...
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Article
Numerical simulation on mechanisms of dense drilling for weakening roofs and its application in roof control
This study proposed a method of dense drilling that could induce the formation of a discontinuous surface to weaken the roof. According to the geological conditions of the Chahasu coal mine, a PFC2D numerical mod...
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Article
Comprehensive assessment of osteoporosis in lumbar spine using compositional MR imaging of trabecular bone
To comprehensively assess osteoporosis in the lumbar spine, a compositional MR imaging technique is proposed to quantify proton fractions for all the water components as well as fat in lumbar vertebrae measure...
