342 Result(s)
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Article
Construction of DNA vaccines and their induced protective immunity against experimental Eimeria tenella infection
In an attempt to construct a DNA vaccine against chicken coccidiosis, the TA4 gene of Eimeria tenella strain BJ was ligated to the mammalian expression vector pcDNA3.1/Zeo(+) to give pcDNA3.1-TA4 (pcDT). Then, E...
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Article
Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyocytes
To construct a recombinant adeno-associated virus (rAAV) vector containing gene encoding phospholamban antisense RNA (asPLB), and analyse its effect on expression of PLB, expression and activity of sarco-endop...
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Article
Swietenia mahagony extract shows agonistic activity to PPAR γ and gives ameliorative effects on diabetic db/db mice
To search the peroxisome proliferator-activated receptor γ (PPARγ) agonists from Swietenia mahagony extract (SmE) and observe the possible ameliorative effects of SmE on diabetic db/db mice.
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Article
Nucleotide Sequences and Functions of the Epstein-Barr Virus Latent Membrane Protein 1 Genes Isolated from Salivary Gland Lymphoepithelial Carcinomas
Epstein-Barr virus (EBV) infection is associated with salivary gland lymphoepithelial carcinoma (SLEC) and nasopharyngeal carcinoma (NPC). EBV is a ubiquitous herpes virus world wide, but EBV-associated SLEC a...
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Article
Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells
To examine the effect of venom from the spider Macrothele raven on cell proliferation and cytotoxicity in human cervical carcinoma, HeLa cells.
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Article
Induction of leukemia cell apoptosis by cheliensisin A involves downregulation of Bcl-2 expression
To investigate the apoptosis-inducing effect of cheliensisin A (GC-51), a novel styryl-lactone isolated from Goniothalamus cheliensis, on human promyelocytic leukemia HL-60 cells and the mechanism of action invol...
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Article
Protective effects of bendazac lysine on early experimental diabetic nephropathy in rats
To investigate the preventive and protective effects of bendazac lysine (BDL) on experimental early diabetic nephropathy (DN) rats.
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Article
Identification of human dopamine D1-like receptor agonist using a cell-based functional assay
To establish a cell-based assay to screen human dopamine D1 and D5 receptor agonists against compounds from a natural product compound library.
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Article
Effects of CpG-ODN on gene expression in formation of foam cells
To investigate the effects of CpG-oligodeoxynucleotide (CpG-ODN) on the formation of macrophage foam cells and related gene expression.
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Article
Induction of liver cytochrome P450 1A2 expression by flutamide in rats
To investigate the modulation of liver cytochrome P450 1A2 (CYP1A2) expression by giving flutamide to adult rats.
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Article
Molecular dynamics simulations of interaction between protein-tyrosine phosphatase 1B and a bidentate inhibitor
To investigate the dynamic properties of protein-tyrosine phosphatase (PTP) 1B and reveal the structural factors responsible for the high inhibitory potency and selectivity of the inhibitor SNA for PTP1B.
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Article
High density lipoprotein 3 inhibits oxidized low density lipoprotein-induced apoptosis via promoting cholesterol efflux in RAW264.7 cells
To investigate the protective effect of high density lipoprotein 3 (HDL3) on oxidized low density lipoprotein (ox-LDL)-induced apoptosis in RAW264.7 cells.
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Article
Open AccessThrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation
Thrombocytopenia is commonly observed in severe leptospirosis. However, previous studies on coagulation alterations during leptospirosis resulted in inconsistent conclusions. Some findings showed that the prom...
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Article
Effective use of corticosteroids in treatment of plastic bronchitis with hemoptysis in Chinese adults
To investigate whether corticosteroids are effective in the treatment of plastic bronchitis with hemoptysis.
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Article
Differentiation of bone marrow mesenchymal stem cells induced by myocardial medium under hypoxic conditions
To explore whether bone marrow mesenchymal stem cells (MSC) can differentiate into myocardial-like cells induced by myocardial medium, especially the hypoxia/reoxygenation-conditioned medium of cardiomyocytes.
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Article
Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives
To design and synthesize a novel class of protein tyrosine kinase inhibitors, featuring the N-(2-oxo-1,2-dihydroquinolin-3-yl-methyl)-thiourea framework.
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Article
Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives
To design and synthesize a novel class of antitumor agents, featuring the 3, 5-substituted indolin-2-one framework.
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Article
3D-QSAR study of 20 (S)-camptothecin analogs
To build up a quantitative structure-activity relationship (QSAR) model of 20 (S)-camptothecin (CPT) analogs for the prediction of the activity of new CPT analogs for drug design.
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Article
Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes
To characterize the molecular mechanisms of nitrofen-induced pulmonary hypoplasia.
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Article
Effects of gestrinone on uterine leiomyoma and expression of c-Src in a guinea pig model
To investigate the effect of gestrinone on uterine leiomyomas and the expression of c-Src, estradiol receptors (ER), and progesterone receptors (PR) in a guinea pig model.
