497 Result(s)
within
Cancer Research
**ao-**a Jiang
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Article
Conformationally altered aortic myosin light chains
Aorta smooth myosin contains two types of light chain, LC20 and LC17, which fold together with the N-terminal region of each heavy chain to form the globular head region of myosin. We demonstrate an altered co...
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Article
mRNA levels of nm23 in murine ascites hepatoma (H22) clones with different lymphatic metastatic potential
Levels of expression of the nm23 gene inversely correlated with metastatic potential in several rodent tumor model systems and human breast carcinoma. In the present study, we examined nm23 mRNA levels in two ...
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Article
Elevated activity of N -acetylglucosaminyltransferase V in human hepatocellular carcinoma
Cell-surface glycoproteins are regarded as candidates for involvement in the spread of tumor cells. N-linked β1-6 branched oligosaccharides may contribute directly to the malignant or metastatic phenotypes of...
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Article
Human papillomavirus,Chlamydia trachomatis, and other risk factors associated with cervical cancer in China
High prevalences of human papillomavirus (HPV) andChlamydia trachomatis infections, and their association with cervical cancer, have been reported in some parts of China. Other factors, including pregnancy and sm...
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Chapter
Polyunsaturated Fatty Acids and Their Role in Cancer Invasion and Metastasis
Highly unsaturated fatty acids (HUFAs) have been demonstrated to have anticancer functions in the past decade. Recently, these fatty acids have been shown to exert a regulatory action on tumour cell motility, ...
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Article
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
Huntington disease (HD) is caused by expansion of a glutamine repeat in the amino-terminal region of huntingtin. Despite its widespread expression, mutant huntingtin induces selective neuronal loss in striatal...
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Chapter
Galectins and Other Endogenous Carbohydrate-Binding Proteins of Animal Bladder
Defects in the glycocalyx of the bladder epithelium may be related to the opment of bladder diseases including interstitial cystitis which is a chronic bladder e of unknown etiology. Indirect evidence has impl...
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Profiling genes differentially expressed in NGX6 overexpressed nasopharyngeal carcinoma cells by cDNA array
Abstract
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Article
Open AccessRARRES3 expression positively correlated to tumour differentiation in tissues of colorectal adenocarcinoma
RARRES3 is a retinoid-inducible class II tumour-suppressor gene. This study analysed the expression of RARRES3 protein in normal, adenoma and carcinoma tissues of the colorectum and its correlation with tumour di...
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Article
Arsenite induces p70S6K1 activation and HIF-1α expression in prostate cancer cells
Arsenite is ubiquitous in the environment, particularly in the form of contaminated water. Although this metal is a known human carcinogen, its exact mechanism of action remains unclear. P70S6K1 phosphorylates...
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Article
Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
Inactivation of the adenosine A2A receptor (A2AR) consistently protects against ischemic brain injury and other neural insults, but the relative contribution of A2ARs on peripheral inflammatory cells versus A2ARs...
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Article
Antisense Tcf inhibits the neoplastic growth of liver cancer cells
T cell transcription factors are nuclear effectors of the Wnt signaling transduction pathway and play crucial roles in embryonic and malignant development. Our previous study showed increased expression level...
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Article
Sensitization of multiple myeloma and B lymphoma lines to dexamethasone and γ-radiation-induced apoptosis by CD40 activation
We examined the effects of CD40 activation with dexamethasone (Dex) or 60Co-γ-irradiation on the growth of malignant B cells in vitro, using the human multiple myeloma (MM) cell line, XG2, and the B lymphoma Daud...
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Article
Polyglutamine expansion of huntingtin impairs its nuclear export
Proteins with polyglutamine (polyQ) expansions accumulate in the nucleus and affect gene expression1,2. The mechanism by which mutant huntingtin (htt) accumulates intranuclearly is not known; wild-type htt, a 350...
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Article
Association between clinical characteristics and expression abundance of RTKN gene in human bladder carcinoma tissues from Chinese patients
Bladder carcinoma is the most common urological malignancy in China. Gene mutation may be one of causes of carcinogenesis in the cancer. We therefore investigated the mRNA expression of RTKN gene in clinic malign...
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Article
Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
The widespread distribution of the tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) in the adult brain1 suggests its role in a broad range of brain functions. Here we show evidence ...
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Article
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior
The hypothalamus responds to circulating leptin and insulin in the control of food intake and body weight. A number of neurotransmitters in the hypothalamus, including γ-aminobutyric acid (GABA), also have key...
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Article
Breast conservative therapy in east part of China: a retrospective cohort study
To compare the effects of breast conservative therapy (BCT) with modified radical mastectomy (MRM) in women with early stage breast cancer in the east part of China. We conducted a matched retrospective cohort...
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Article
Comparison of a proteomic approach with a microarray-based approach to detect exons in the mouse genome
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Chapter
Polyunsaturated Fatty Acids and Prostate Cancer Metastasis
Polyunsaturated fatty acids have been demonstrated to have anticancer activities, on a number of tumor types including prostate cancer. There is evidence that these fatty acids may also influence the metastati...
