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Article
Root system architecture change in response to waterlogging stress in a 448 global collection of rapeseeds (Brassica napus L.)
A novel image-based screening method for precisely identifying genotypic variations in rapeseed RSA under waterlogging stress was developed. Five key root traits were confirmed as good indicators of waterloggi...
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Article
Calcium Nanoparticles and Abscisic Acid Improve Drought Tolerance, Mineral Nutrients Uptake and Inhibitor-Mediated Photosystem II Performance in Brassica napus
Plant yield is severely hampered by drought, affirming the urgent need to develop strategies to improve plant growth and drought tolerance. The synergistic application of ABA and calcium nanoparticles (Ca-NPs)...
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Article
Lack of Hematodinium microscopic detection in crustaceans at the northern and southern ends of the Wadden Sea and an update of its distribution in Europe
Hematodinium is a parasitic dinoflagellate with a wide distribution along the European coastline. We investigated whether Hematodinium occurs in the Wadden Sea, a large tidal flat system spanning the Netherlands,...
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Article
Open AccessThe functional divergence of homologous GPAT9 genes contributes to the erucic acid content of Brassica napus seeds
The early allopolyploid Brassica napus was a hybrid of two Brassica species, that had undergone a whole genome duplication event followed by genome restructuring, including deletions and small scale duplications....
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Article
Open AccessWhole genome analysis of Bacillus amyloliquefaciens TA-1, a promising biocontrol agent against Cercospora arachidicola pathogen of early leaf spot in Arachis hypogaea L
Early leaf spot disease, caused by Cercospora arachidicola, is a devastating peanut disease that has severely impacted peanut production and quality. Chemical fungicides pollute the environment; however, Bacillus
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Article
Knowledge Map and Global Trends in Root Exudates Research from 2012 to 2021: a Bibliometric Analysis
The number of publications on root exudates has been increasing continuously, because root exudates play a key role in soil biochemical cycles and plant-soil feedbacks. However, global trend and research hotpo...
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Article
Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy
Immune checkpoint blockade therapy has drastically improved the prognosis of certain advanced-stage cancers. However, low response rates and immune-related adverse events remain important limitations. Here, we...
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Article
Open AccessDisruption of three polyamine uptake transporter genes in rice by CRISPR/Cas9 gene editing confers tolerance to herbicide paraquat
Weeds are a major biotic constraint that can cause dramatic crop production losses. Herbicide technology has been widely used by farmers as the most cost-effective weed control measure, and development of new ...
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Article
Open AccessMechanism of cancer stemness maintenance in human liver cancer
Primary liver cancer mainly includes the following four types: hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-...
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Article
Development of MEMS directed evolution strategy for multiplied throughput and convergent evolution of cytochrome P450 enzymes
Directed evolution (DE) inspired by natural evolution (NE) has been achieving tremendous successes in protein/enzyme engineering. However, the conventional “one-protein-for-one-task” DE cannot match the “multi...
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Article
Open AccessSix New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata
Ten 3,5-dimethylcoumarins (1–6 and 8‒11) involving six new ones (1–6), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and
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Article
Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells
Glioblastoma (GBM) contains abundant tumor-associated macrophages (TAMs). The majority of TAMs are tumor-promoting macrophages (pTAMs), while tumor-suppressive macrophages (sTAMs) are the minority. Thus, repro...
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Article
Open AccessGut microbiota changes in preeclampsia, abnormal placental growth and healthy pregnant women
Preeclampsia (PE) is a condition of high blood pressure that is usually concurrent with proteinuria in pregnancy. PE complicates the management of both maternal and fetal health and contributes to most adverse...
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Article
The parasitic dinoflagellate Hematodinium infects marine crustaceans
Hematodinium is a type of parasitic dinoflagellate that infects marine crustaceans globally. The parasite lives mainly in the hemolymph or hemocoels of affected hosts, and results in mortalities due to malfunctio...
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Article
Open AccessExtracellular DNA released by glycine-auxotrophic Staphylococcus epidermidis small colony variant facilitates catheter-related infections
Though a definitive link between small colony variants (SCVs) and implant-related staphylococcal infections has been well-established, the specific underlying mechanism remains an ill-explored field. The prese...
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Article
SAA1 regulates pro-labour mediators in term labour by activating YAP pathway
Term labour is associated with activation of inflammation which results in myometrial contractility, cervical ripening and decidual/membrane rupture. Serum amyloid A1 (SAA1) is an acute response protein, whose...
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Article
The cytoplasmic loops of AgrC contribute to the quorum-sensing activity of Staphylococcus aureus
In Staphylococcus aureus, the accessory gene regulator (agr) quorum-sensing system is thought to play an important role in biofilm formation. The histidine kinase AgrC is one of the agr system components and acti...
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Article
Open AccessComparison of the cytoplastic genomes by resequencing: insights into the genetic diversity and the phylogeny of the agriculturally important genus Brassica
The genus Brassica mainly comprises three diploid and three recently derived allotetraploid species, most of which are highly important vegetable, oil or ornamental crops cultivated worldwide. Despite being exten...
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Article
Open AccessProtective mechanisms of melatonin against selenium toxicity in Brassica napus: insights into physiological traits, thiol biosynthesis and antioxidant machinery
The ubiquitous signaling molecule melatonin (N-acetyl-5-methoxytryptamine) (MT) plays vital roles in plant development and stress tolerance. Selenium (Se) may be phytotoxic at high concentrations. Interactions be...
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Article
Nanoscale fiber-optic force sensors for mechanical probing at the molecular and cellular level
There is an ongoing need to develop ultrasensitive nanomechanical instrumentation that has high spatial and force resolution, as well as an ability to operate in various biological environments. Here, we prese...