104 Result(s)
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Open AccessA qualitative study of geriatric specialist nurses’ experiences to navigate delirium in the elderly
The experiences and perceptions of geriatric specialist nurses are pivotal to understanding the complexities of managing delirium and to develo** effective nursing interventions. This qualitative study aims ...
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Open AccessCorrection: Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
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Cast versus Kirschner wire fixation in type II paediatric phalangeal neck fractures
To compare the outcomes of type II pediatric phalangeal neck fractures (PPNFs) treated with closed reduction and cast immobilization (CRCI) versus closed reduction percutaneous pinning (CRPP), and evaluated th...
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Open AccessBudget Impact of Introducing Fixed-Duration Mosunetuzumab for the Treatment of Relapsed or Refractory Follicular Lymphoma After Two or More Lines of Systemic Therapy in the USA
This study aimed to assess the budget impact of introducing fixed-duration mosunetuzumab as a treatment option for adult patients with relapsed or refractory follicular lymphoma after at least two prior system...
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Open AccessOverexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
This study aimed to explore the expression, molecular mechanism and its biological function of potassium two pore domain channel subfamily K member 1 (KCNK1) in bladder cancer (BC).
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Open AccessOverexpression of SYNGAP1 suppresses the proliferation of rectal adenocarcinoma via Wnt/β-Catenin signaling pathway
Rectal adenocarcinoma (READ) is a common malignant tumor of the digestive tract. Growing studies have confirmed Ras GTPase-activating proteins are involved in the progression of several tumors. This study aime...
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Open AccessMelatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis
Influenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in which IAV infection may further evoke abnormal macrophage pol...
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Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic β-cell Dysfunction
While the reduction of transient receptor potential channel subfamily M member 5 (TRPM5) has been reported in islet cells from type 2 diabetic (T2D) mouse models, its role in lipotoxicity-induced pancreatic β-...
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Open AccessImpact of age, sex, and thyroid autoimmunity on the association between selenium intake and type 2 diabetes mellitus
The association between dietary selenium(Se) intake and type 2 diabetes mellitus (T2DM) remains controversial. The present study aimed to investigate this association using data from the National Health and Nu...
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Open AccessDynamic changes in glymphatic function in reversible cerebral vasoconstriction syndrome
The pathophysiology of the reversible cerebral vasoconstriction syndrome (RCVS) remains enigmatic and the role of glymphatics in RCVS pathophysiology has not been evaluated. We aimed to investigate RCVS glymph...
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Automated identification and quantification of metastatic brain tumors and perilesional edema based on a deep learning neural network
This paper presents a deep learning model for use in the automated segmentation of metastatic brain tumors and associated perilesional edema.
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Noninvasive investigations of human glymphatic dynamics in a diseased model
To explore human glymphatic dynamics in a diseased model via a noninvasive technique.
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Treatment and survival of patients with small cell lung cancer and brain metastasis
To elucidate treatment patterns and their outcomes in patients with small cell lung cancer (SCLC) and brain metastasis (BM).
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Quality and consistency of clinical practice guideline recommendations for PET/CT and PET: a systematic appraisal
To systematically appraise the methodologies used for guidelines for positron emission tomography (PET) imaging and to compare the consistency of these recommendations.
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Functional disruptions of the brain network in low back pain: a graph-theoretical study
The aim of this study was to investigate alterations in the topological organization of whole-brain functional networks in patients with chronic low back pain (CLBP) and characterize the relationship of these ...
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Hypertension Treatment in Frail Older Adults: A Systematic Review and Appraisal of Guidelines
Managing hypertension in frail older patients is challenging. Several institutions and organizations have published up-to-date hypertension guidelines suggesting frailty screening among older hypertensive pati...
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Is it advisable to perform radiosurgery for EGFR-TKI-controlled brain metastases? A retrospective study of the role of radiosurgery in lung cancer treatment
Given the availability of TKIs with high central nervous system efficacy, the question arises as to whether upfront SRS provides additional clinical benefits. The goal of this study was to characterize the cli...
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Improved survival and intracranial tumor control of EGFR-mutated NSCLC patients with newly developed brain metastases following stereotactic radiosurgery and EGFR-TKI: a large retrospective cohort study and meta-analyses
To examine the differential effects of SRS and TKI on EGFR-mutated NSCLC patients with brain metastases (BMs) and outcomes following continuation of the same TKI agent in case of new BMs.
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Open AccessComparison of sound touch elastography and quantification for assessing the renal pathologic changes in patients with proteinuria
Sound touch elastography (STE) and sound touch quantification (STQ) are novel imaging methods to evaluate tissue stiffness. This study aims to investigate renal stiffness in patients with chronic kidney diseas...
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PDGF-BB/PDGFRβ induces tumour angiogenesis via enhancing PKM2 mediated by the PI3K/AKT pathway in Wilms’ tumour
Platelet-derived growth factor receptor-β (PDGFRβ) is a critical type III receptor tyrosine kinase family member, which is involved in Wilms’ tumour (WT) metastasis and aerobic glycolysis. The role of PDGFRβ i...
