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Article
Open AccessDifferential expression profiling between the relative normal and dystrophic muscle tissues from the same LGMD patient
Limb-girdle muscular dystrophy (LGMD) is a group of heterogeneous muscular disorders with autosomal dominant and recessive inheritance, in which the pelvic or shoulder girdle musculature is predominantly or pr...
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Article
The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression
Fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism, located in the FGFR4 gene exon 9, was reported to be associated with malignant tumors prognosis; however, there has been no relevant research...
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Chapter and Conference Paper
Research on the File Encryption System Based on Minifilter Driver
The analysis is made on the security in the information process in this paper. In order to avoid system breakdown under the process by traditional development of file encryption and decryption system, a new ap...
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Article
Open AccessHyperammonia induces specific liver injury through an intrinsic Ca2+-independent apoptosis pathway
Numerous pathological processes that affect liver function in patients with liver failure have been identified. Among them, hyperammonia is one of the most common phenomena.The purpose of this study was to det...
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Article
A single-arm clinical study of continuous usage of bevacizumab as second-line chemotherapy for Chinese patients with metastatic colorectal cancer
Recent studies demonstrated that second-line chemotherapy of continuous usage of bevacizumab after initial disease progression improved survivals in Caucasian patients with metastatic colorectal cancer (mCRC)....
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Article
Intensive Versus Conventional Glycemic Control in Patients with Diabetes During Enteral Nutrition After Gastrectomy
This study compared intensive and conventional glycemic management strategies in diabetic patients receiving enteral nutrition after gastrectomy.
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Article
Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer
To clarify the role of fibroblast growth factor receptor 4 (FGFR4) in gastric cancer (GC) and explore the therapeutic value of BGJ398 targeted to FGFR4. We constructed lentivirus vectors to stably knockdown FG...
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Article
The over-expression of FGFR4 could influence the features of gastric cancer cells and inhibit the efficacy of PD173074 and 5-fluorouracil towards gastric cancer
The aim was to investigate the function of fibroblast growth factor receptor 4 (FGFR4) in gastric cancer (GC) and explore the treatment value of agent targeted to FGFR4. Function assays in vitro and in vivo we...
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Article
IL-33 Treatment Attenuates the Systemic Inflammation Reaction in Acinetobacter baumannii Pneumonia by Suppressing TLR4/NF-κB Signaling
Interleukin (IL)-33 treatment has been reported to reduce mortality in a rat model of sepsis, and the present study aimed to determine whether this effect of IL-33 is achieved through a reduction in the system...
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Article
Open AccessODAE: Ontology-based systematic representation and analysis of drug adverse events and its usage in study of adverse events given different patient age and disease conditions
Drug adverse events (AEs), or called adverse drug events (ADEs), are ranked one of the leading causes of mortality. The Ontology of Adverse Events (OAE) has been widely used for adverse event AE representation...
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Article
Open AccessLiquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA
Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of death worldwide. Due to latent liver disease, late diagnosis, and nonresponse to systemic treatments, surgical resection ...
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Article
Open AccessClinical features and outcomes of seven patients with COVID-19 in a family cluster
The family cluster is one of most important modes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission throughout China, and more details are needed about how family clusters cause the ...
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Chapter and Conference Paper
Overall Design of Dual Energy Source Power System of Automobile
A driving power transmission system and a vehicle control strategy are designed to increase endurance mileages and improve the energy utilization rate, to analyze an existing dual motor driving power structure...
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Article
Open AccessCharacterization and comparison of the bacterial community between complete intensive and extensive feeding patterns in pigs
To investigate and compare the gut microbiota structures in complete intensive feeding pattern (CP) and extensive feeding pattern (EP) groups, a total of 20 pigs were divided into two groups and fed the same d...
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Article
Recycling of Carbon Fiber-reinforced Epoxy Resin-based Composites Using a Benzyl Alcohol/Alkaline System
High-efficiency recycling of carbon fiber-reinforced epoxy resin-based composites is difficult because of their three-dimensional network structure. In this article, a benzyl alcohol/alkaline system was used t...
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Article
Open AccessClinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae
Carbapenem-resistant and hypervirulent K. pneumoniae (CR-HvKP) strains that have emerged recently have caused infections of extremely high mortality in various countries. In this study, we discovered a conjugativ...
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Article
Open AccessAssociations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study
While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-...
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Article
Open AccessCharacteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China
Asthma is a heterogeneous disease with variable symptoms, which presents with cough either as the sole or predominant symptom with or without wheezing. We compared the clinical and pathophysiological character...
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Article
Open AccessA comprehensive update on CIDO: the community-based coronavirus infectious disease ontology
The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of develo** effective and saf...
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Article
Open AccessTargeting pyroptosis in breast cancer: biological functions and therapeutic potentials on It
Pyroptosis is a lytic and inflammatory type of programmed cell death that is mediated by Gasdermin proteins (GSDMs). Attractively, recent evidence indicates that pyroptosis involves in the development of tumor...
