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Article
Open AccessDifferential expression profiling between the relative normal and dystrophic muscle tissues from the same LGMD patient
Limb-girdle muscular dystrophy (LGMD) is a group of heterogeneous muscular disorders with autosomal dominant and recessive inheritance, in which the pelvic or shoulder girdle musculature is predominantly or pr...
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Article
Open AccessHyperammonia induces specific liver injury through an intrinsic Ca2+-independent apoptosis pathway
Numerous pathological processes that affect liver function in patients with liver failure have been identified. Among them, hyperammonia is one of the most common phenomena.The purpose of this study was to det...
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Article
Open AccessODAE: Ontology-based systematic representation and analysis of drug adverse events and its usage in study of adverse events given different patient age and disease conditions
Drug adverse events (AEs), or called adverse drug events (ADEs), are ranked one of the leading causes of mortality. The Ontology of Adverse Events (OAE) has been widely used for adverse event AE representation...
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Article
Open AccessLiquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA
Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of death worldwide. Due to latent liver disease, late diagnosis, and nonresponse to systemic treatments, surgical resection ...
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Article
Open AccessClinical features and outcomes of seven patients with COVID-19 in a family cluster
The family cluster is one of most important modes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission throughout China, and more details are needed about how family clusters cause the ...
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Article
Open AccessCharacterization and comparison of the bacterial community between complete intensive and extensive feeding patterns in pigs
To investigate and compare the gut microbiota structures in complete intensive feeding pattern (CP) and extensive feeding pattern (EP) groups, a total of 20 pigs were divided into two groups and fed the same d...
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Article
Open AccessClinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae
Carbapenem-resistant and hypervirulent K. pneumoniae (CR-HvKP) strains that have emerged recently have caused infections of extremely high mortality in various countries. In this study, we discovered a conjugativ...
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Article
Open AccessAssociations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study
While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-...
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Article
Open AccessCharacteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China
Asthma is a heterogeneous disease with variable symptoms, which presents with cough either as the sole or predominant symptom with or without wheezing. We compared the clinical and pathophysiological character...
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Article
Open AccessA comprehensive update on CIDO: the community-based coronavirus infectious disease ontology
The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of develo** effective and saf...
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Article
Open AccessTargeting pyroptosis in breast cancer: biological functions and therapeutic potentials on It
Pyroptosis is a lytic and inflammatory type of programmed cell death that is mediated by Gasdermin proteins (GSDMs). Attractively, recent evidence indicates that pyroptosis involves in the development of tumor...
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Article
Open AccessA pipeline for sample tagging of whole genome bisulfite sequencing data using genotypes of whole genome sequencing
In large-scale high-throughput sequencing projects and biobank construction, sample tagging is essential to prevent sample mix-ups. Despite the availability of fingerprint panels for DNA data, little research ...
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Article
Open AccessNon-orthogonal optical multiplexing empowered by deep learning
Orthogonality among channels is a canonical basis for optical multiplexing featured with division multiplexing, which substantially reduce the complexity of signal post-processing in demultiplexing. However, i...
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Article
Open AccessSpatio-temporal spread and evolution of Lassa virus in West Africa
Lassa fever is a hemorrhagic disease caused by Lassa virus (LASV), which has been classified by the World Health Organization as one of the top infectious diseases requiring prioritized research. Previous stud...
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Article
Open AccessCrosstalk between cancer-associated fibroblasts and regulated cell death in tumors: insights into apoptosis, autophagy, ferroptosis, and pyroptosis
Cancer-associated fibroblasts (CAFs), the main stromal component of the tumor microenvironment (TME), play multifaceted roles in cancer progression through paracrine signaling, exosome transfer, and cell inter...
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Article
Open AccessBenmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial
Immunochemotherapy is the first-line standard for extensive-stage small-cell lung cancer (ES-SCLC). Combining the regimen with anti-angiogenesis may improve efficacy. ETER701 was a multicenter, double-blind, r...
