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Article
Multifunctional polyurethane coatings with excellent antifouling and self-healing properties
Polydimethylsiloxane (PDMS) has been widely used to improve the antifouling properties of polyurethane (PU) coatings due to its low surface energy. Herein, a novel type of waterborne polyurethane (WPU) coating...
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Article
Influence of soil parameter spatial variability on railway loess-filled embankment settlement
This study involved an embankment settlement analysis of a case study of the railway loess-filled embankment section of the Baozhong railway in Guyuan, China. The two-dimensional spatial variability of the soi...
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Article
Complement Inhibition Reduces Early Erythrolysis, Attenuates Brain Injury, Hydrocephalus, and Iron Accumulation after Intraventricular Hemorrhage in Aged Rats
Blood components released by erythrolysis play an important role in secondary brain injury and posthemorrhagic hydrocephalus (PHH) after intraventricular hemorrhage (IVH). The current study examined the impact...
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Article
Surface modification of sodium hyaluronate with dopamine to enhance emulsifying capacity and application performance
Hyaluronic acid (HA) is a mucopolysaccharide alternately linked by glucuronic acid and n-Acetylglucosamine as disaccharide units. This study prepared HA derivative (DA-HA) by modifying sodium hyaluronate with ...
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Article
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy
The pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a key role in liver disease. However,...
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Article
Non-trade-off Changes in Soil Conservation Service and Soil Loss on the Tibetan Plateau Underlying the Impacts of Climate Change and human activities
Climate change and human activities have significantly influenced soil loss and the soil conservation service, posed threats to regional ecological sustainability. However, the relationships and underlying dri...
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Article
Open AccessResearch progress on the polysaccharide extraction and antibacterial activity
Over time, the amount of germs resistant to antibacterial medications has been steadily rising because of their prolonged and indiscriminate use. The increase in drug resistance significantly threatens to huma...
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Article
Open AccessFeasibility of utilizing mediastinal drains alone following esophageal cancer surgery: a retrospective study
It was typically necessary to place a closed thoracic drainage tube for drainage following esophageal cancer surgery. Recently, the extra use of thoracic mediastinal drainage after esophageal cancer surgery ha...
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Article
Open AccessPINN-CHK: physics-informed neural network for high-fidelity prediction of early-age cement hydration kinetics
Cement hydration kinetics, characterized by heat generation in early-age concrete, poses a modeling challenge. This work proposes a physics-informed neural network (PINN) named PINN-CHK designed for cement hyd...
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Article
Open AccessChoroid plexus immune cell response in murine hydrocephalus induced by intraventricular hemorrhage
Intraventricular hemorrhage (IVH) and associated hydrocephalus are significant complications of intracerebral and subarachnoid hemorrhage. Despite proximity to IVH, the immune cell response at the choroid plex...
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Article
Open AccessThe impact of high-speed railway construction on regional economic development in Hubei Province
Based on the panel data of 16 cities in Hubei Province from 2009 to 2019 (excluding the data during Covid-19 pandemic period), we construct multi-temporal difference-in-differences model (DID) and Spatial Durb...
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Article
Open AccessInduction of therapeutic immunity and cancer eradication through biofunctionalized liposome-like nanovesicles derived from irradiated-cancer cells
Immunotherapy has revolutionized the treatment of cancer. However, its efficacy remains to be optimized. There are at least two major challenges in effectively eradicating cancer cells by immunotherapy. Firstl...
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Article
Open AccessTranscriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies
Cancer stem cells (CSCs) were first discovered in the 1990s, revealing the mysteries of cancer origin, migration, recurrence and drug-resistance from a new perspective. The expression of pluripotent genes and ...
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Article
Open AccessLiquid biopsy techniques and lung cancer: diagnosis, monitoring and evaluation
Lung cancer stands as the most prevalent form of cancer globally, posing a significant threat to human well-being. Due to the lack of effective and accurate early diagnostic methods, many patients are diagnose...
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Article
Benchmark Study on a Novel Online Dataset for Standard Evaluation of Deep Learning-based Pavement Cracks Classification Models
Highway agencies and practitioners expect to have the most efficient method with adequate accuracy when choosing a deep learning-based model for pavement crack classification. However, many works are implement...
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Article
Resonance and stability of 3rd super-harmonic and 1/3rd sub-harmonic of fractional duffing system
In this paper, the dynamic characteristics of a fractional Duffing system are studied under the 3rd super-harmonic resonance and 1/3rd sub-harmonic resonance. Firstly, the approximate analytical solution of th...
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Article
Author Correction: An engineered influenza virus to deliver antigens for lung cancer vaccination
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Article
An engineered influenza virus to deliver antigens for lung cancer vaccination
The development of cancer neoantigen vaccines that prime the anti-tumor immune responses has been hindered in part by challenges in delivery of neoantigens to the tumor. Here, using the model antigen ovalbumin...
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Article
Open AccessDeubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis
Cisplatin-based chemotherapy improves the control of distant metastases in patients with nasopharyngeal carcinoma (NPC); however, around 30% of patients fail treatment due to acquired drug resistance. Epigenet...
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Article
SOX5 Attenuates Toxicity in Neural Stem Cells Induced by Sevoflurane Anesthesia via Regulating the PI3K/AKT Pathway
Differentiation and self-renewal capacity of neural stem cells are essential for the development and function of brain. Anesthesia exposure inhibits the differentiation and self-renewal capacity of neural stem...
