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Article
Divergence in Chinese Sexual Attitudes: An Age–Period–Cohort Analysis
A crucial component of comprehending societal change is understanding how sexual attitudes have evolved over time. The substantial and typical changes in China have created an ideal quasi-experimental design a...
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Article
Open AccessComprehensive analysis of T-cell regulatory factors and tumor immune microenvironment in stomach adenocarcinoma
Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide and is associated with high morbidity and mortality rates. However, the specific biomarkers used to predict the postoperative prognos...
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Article
Open AccessNanomaterial-encapsulated STING agonists for immune modulation in cancer therapy
The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor immunity through immune effector responses. Targeting the cGAS-STIN...
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Article
Open AccessSingle-cell RNA-seq analysis decodes the kidney microenvironment induced by polystyrene microplastics in mice receiving a high-fat diet
In recent years, the environmental health issue of microplastics has aroused an increasingly significant concern. Some studies suggested that exposure to polystyrene microplastics (PS-MPs) may lead to renal in...
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Chapter and Conference Paper
Fusion Boundary and Gradient Enhancement Network for Camouflage Object Detection
The problems of boundary interruption and missing internal texture feature have not been well solved in the current camouflaged object detection model, and the parameters of the model are generally large. To o...
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Article
Construction of cuproptosis signature based on bioinformatics and experimental validation in clear cell renal cell carcinoma
Cuproptosis was defined as a novel nonapoptotic cell death pathway and its potential function in clear cell renal cell carcinoma (ccRCC) remains unclear.
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Article
Open AccessIntegrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds
Angelica sinensis roots (Angelica roots) are rich in many bioactive compounds, including phthalides, coumarins, lignans, and terpenoids. However, the molecular bases for their biosynthesis are still poorly unders...
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Article
Deciphering the implications of mitophagy-related signatures in clinical outcomes and microenvironment heterogeneity of clear cell renal cell carcinoma
The role of mitophagy in various cancer-associated biological processes is well recognized. Nonetheless, the comprehensive implications of mitophagy in clear cell renal cell carcinoma (ccRCC) necessitate furth...
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Article
Topside ionospheric TEC modeling using multiple LEO satellites based on genetic algorithm-optimized machine learning models
Machine learning approaches are introduced to model the three-dimensional topside total electron content (TEC) using multiple low Earth orbit (LEO) satellites. The three-dimensional topside TEC can be describe...
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Article
NSUN5-FTH1 Axis Inhibits Ferroptosis to Promote the Growth of Gastric Cancer Cells
Recent studies revealed that NOP2/Sun RNA methyltransferase 5 (NSUN5) - ferritin heavy chain (FTH1) pathway is associated with ferroptosis in stem cells, whereas its roles in gastric cancer are still unclear. ...
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Article
Open AccessFMSA: a meta-learning framework-based fast model stealing attack technique against intelligent network intrusion detection systems
Intrusion detection systems are increasingly using machine learning. While machine learning has shown excellent performance in identifying malicious traffic, it may increase the risk of privacy leakage. This p...
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Article
Open AccessSurface-anchored microbial enzyme-responsive solid lipid nanoparticles enabling colonic budesonide release for ulcerative colitis treatment
Colon-targeted oral drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC), which is a disease with high relapse and remission rates associated with immune system inflammation...
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Article
Certification of visinin-like protein-1 (VILIP-1) certified reference material by amino acid-based and sulfur-based liquid chromatography isotope dilution mass spectrometry
As an emerging neurodegenerative disease, Alzheimer’s disease (AD) has become a leading cause of dementia in older adults. Visinin-like protein-1 (VILIP-1) is an increasingly used biomarker for AD besides the ...
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Chapter and Conference Paper
BGEK: External Knowledge-Enhanced Graph Convolutional Networks for Rumor Detection in Online Social Networks
Nowadays, social media has become a dominant platform for disseminating news and information. However, it also accelerated the spread of rumors, which causes great impacts on the real world. Therefore, the det...
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Article
Publisher Correction: Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma
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Article
Biodegradable, superhydrophobic walnut wood membrane for the separation of oil/water mixtures
The preparation of environmentally friendly oil/water separation materials remains a great challenge. Freeze-drying of wood after lignin removal yields wood aerogels, which can be used as substrates to prepare...
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Article
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma
Cholesterol contributes to the structural basis of biological membranes and functions as a signaling molecule, whose dysregulation has been associated with various human diseases. Here, we report that the long...
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Article
Prognostic value, DNA variation and immunologic features of a tertiary lymphoid structure-related chemokine signature in clear cell renal cell carcinoma
The tumor microenvironment (TME) and tertiary lymphoid structures (TLS) affect the occurrence and development of cancers. How the immune contexture interacts with the phenotype of clear cell renal cell carcino...
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Article
Open AccessDeciphering the role of miR-187-3p/LRFN1 axis in modulating progression, aerobic glycolysis and immune microenvironment of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant genitourinary cancers with high recurrence risk worldwide. Recently, multi-omics data facilitate obtaining a molecular landscape of t...
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Article
Open AccessA bioinformatic analysis study of m7G regulator-mediated methylation modification patterns and tumor microenvironment infiltration in glioblastoma
Glioblastoma is one of the most common brain cancers in adults, and is characterized by recurrence and little curative effect. An effective treatment for glioblastoma patients remains elusive worldwide. 7-meth...
