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Article
Open AccessEffect of Annexin A2 on prognosis and sensitivity to immune checkpoint plus tyrosine kinase inhibition in metastatic renal cell carcinoma
Immunotherapy (IO) plus tyrosine kinase inhibitor (TKI) therapy is the first-line recommendation for advanced renal cell carcinoma (RCC), but no biomarker has been approved for it. Annexin A2 (ANXA2) can induc...
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Article
Open AccessRUNX3 pathway signature predicts clinical benefits of immune checkpoint inhibition plus tyrosine kinase inhibition in advanced renal cell carcinoma
Checkpoint inhibitor immunotherapy plus tyrosine kinase inhibitor (IO/TKI) have been recently recommended as standard first-line therapy for advanced renal cell carcinoma, while no clinical-available biomarker...
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Article
An interpretable framework for the hazard assessment of debris flow based on an improved AHP-EWM method and the SHAP model: a case study of Heishuiwan gully
Debris flows are significant geological hazard in Bei**g mountainous areas. As a non-engineering means, hazard assessment is instructive for debris flow prevention and control. A rational assessment framework...
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Article
Unfavorable immunotherapy plus tyrosine kinase inhibition outcome of metastatic renal cell carcinoma after radical nephrectomy with increased ADAM9 expression
Immunotherapy plus tyrosine kinase inhibitor (IO-TKI) has become the standard first-line therapy for advanced renal cell carcinoma (RCC). However, the modest response rate of IO-TKI therapy and the absence of ...
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Article
A new framework for geometrical investigation and stability analysis of high-position concealed dangerous rock blocks
The rock slopes along the Sichuan–Tibet railway are characterized by noncontactless, inaccessible, dramatically fluctuating topography and large-scale areas. Numerous high-position, concealed dangerous rock bl...
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Article
Evolutionary characteristics of ecosystem services and ecological risks at highly developed economic region: A case study on Yangtze River Delta, China
Ecosystem services (ES) can mitigate ecological risks (ER), yet these services can also be affected by ER. Based on land use data, socioeconomic data, landscape index, and spatial analysis techniques such as s...
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Article
Automatic identification of rock discontinuity sets using modified agglomerative nesting algorithm
Identification of rock discontinuity sets is essential for each studied jointed rock slope, and is also an initial step in many existing methods for rock slope stability analysis. This paper presents a new hie...
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Chapter and Conference Paper
A Design Idea of Multicast Application in Satellite Communication Network
IP multicast has the advantages of high network utilization, low bandwidth overhead and strong scalability, which plays a great role in a large number of terrestrial Internet applications. However, in satellit...
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Chapter and Conference Paper
Research on Power Control Algorithm in the Multi-target TT&C System
In the multi-target TT&C system of relay satellite, due to the different distances between users and satellites, the strong signals of near users will restrain the weak signals of long-distance users and reduc...
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Chapter and Conference Paper
Timeliness Analysis and Countermeasure of Remote Control of Equipment Monitoring and Control System
With the development of communication technology and computer network technology, satellite ground stations have varying degrees of construction equipment monitoring system, can manage distribution in differen...
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Article
Long-term trends in daily precipitation over the Yangtze River Delta region during 1960–2012, Eastern China
Based on daily precipitation data from 24 stations over the Yangtze River Delta (YRD) region, the long-term trends of daily precipitation are analyzed during the period 1960–2012 using 12 precipitation indices...
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Article
Degrading river network due to urbanization in Yangtze River Delta
Evolution of river systems under the background of human activities has been a heated topic among geographers and hydrologists. Spatial and temporal variations of river systems during the 1960s–2010s in the Ya...
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Article
Dietary carrot consumption and the risk of prostate cancer
Previous studies regarding the association between carrot intake and prostate cancer risk have reported inconsistent results. We conducted a meta-analysis to summarize evidence on this association and to quant...
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Article
Open AccessMicroRNA-320c inhibits tumorous behaviors of bladder cancer by targeting Cyclin-dependent kinase 6
Increasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to human disease including cancer. Previous miRNA microarray analysis illustrated that miR-320c is down-regulated in ...
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Article
Open AccessDownregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway
Emerging evidence has suggested that dysregulation of miR-182-5p may contribute to tumor development and progression in several types of human cancers. However, its role in renal cell carcinoma (RCC) is still ...
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Article
Open AccessMicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1
Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to human disease including carcinogenesis and tumor metastasis in human. miR-124-3p is down-regulated in variou...
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Article
MicroRNA-409-3p inhibits migration and invasion of bladder cancer cells via targeting c-Met
There is increasing evidence suggesting that dysregulation of certain microRNAs (miRNAs) may contribute to tumor progression and metastasis. Previous studies have shown that miR-409-3p is dysregulated in some ...
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Article
Jasmonates modulate the promotion effects induced by SNP on root development of wheat under osmotic stress through lipoxygenase activation
We investigated promotion effects of exogenous sodium nitroprusside (SNP) on wheat seedling (Triticum aestivum L.) lateral root (LR) and root hair development, and the relationship between endogenous jasmonate (J...
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Article
Open AccessApigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells
Apigenin (4’,5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell li...
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Article
Open AccessQuantitative assessment of the associations between XRCC1 polymorphisms and bladder cancer risk
The XRCC1 polymorphisms have been implicated in bladder cancer risk, but individually published studies show inconsistent results. The aim of our study was to clarify the effects of XRCC1 variants on bladder canc...
