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Article
Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1
Generally shortened 3′ UTR due to alternative polyadenylation (APA) is widely observed in cancer, but its regulation mechanisms for cancer are not well characterized. Here, with profiling of APA in colorectal ...
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Article
Rapid and sensitive visual detection of avian leukosis virus by reverse transcription loop-mediated isothermal amplification combined with a lateral flow immunochromatographic strip assay
Considering that avian leukosis virus (ALV) infection has inflicted massive economic losses on the poultry breeding industry in most countries, its early diagnosis remains an important measure for timely treat...
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Article
Cloud Top Pressure Retrieval Using Polarized and Oxygen A-band Measurements from GF5 and PARASOL Satellites
Cloud top pressure (CTP) is one of the critical cloud properties that significantly affects the radiative effect of clouds. Multi-angle polarized sensors can employ polarized bands (490 nm) or O2 A-bands (763 and...
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Article
Study on the influence of input variables on the supervised machine learning model for landslide susceptibility map**
Supervised machine learning (ML) models are currently popular in landslide susceptibility map** (LSM). However, the input variables of these models have some inherent limitations in terms of the lack of nonl...
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Article
Element-scale pullout test study on the mechanical behavior of grouted anchor–soil interface subjected to ground pressure
The soil–anchor interface mechanical behavior is of practical importance for the bearing performance of ground anchors. Element-scale pullout test is a simple, reliable, and economical technique to investigate...
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Article
Publisher Correction: Ozone pollution mitigation strategy informed by long-term trends of atmospheric oxidation capacity
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Article
Open AccessEstimating hourly surface shortwave radiation over northeast of the Tibetan Plateau by assimilating Himawari-8 cloud optical thickness
To reduce the uncertainty estimation of clouds and improve the forecast of surface shortwave radiation (SSR) over the Tibetan Plateau, a new cloud assimilation system is proposed which is the first attempt to ...
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Article
Ozone pollution mitigation strategy informed by long-term trends of atmospheric oxidation capacity
Tropospheric ozone pollution is a critical air-quality concern in China. However, the most effective mitigation approach remains unclear, with prioritizing the reduction of volatile organic compounds or nitrog...
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Article
Toward Establishing a Low-cost UAV Coordinated Carbon Observation Network (LUCCN): First Integrated Campaign in China
In this study, we introduce our newly developed measurement-fed-perception self-adaption Low-cost UAV Coordinated Carbon Observation Network (LUCCN) prototype. The LUCCN primarily consists of two categories of...
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Article
Open AccessThe m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma
Metastasis remains the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC), in which sustained activation of the Notch signaling plays a critical role. N6-Methyladenosine (m6A)-med...
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Article
Mechanism of tumor-derived extracellular vesicles in prostatic cancer progression through the circFMN2/KLF2/RNF128 axis
Circular RNAs (circRNAs) are a major type of cargos encapsulated in extracellular vesicles (EVs) and regulate the progression of prostatic cancer (PC). This study was conducted to explore the role of tumor-der...
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Article
Open AccessAnaplasma phagocytophilum Ats-1 enhances exosome secretion through Syntenin-1
Anaplasma phagocytophilum is an intracellular obligate parasite that causes granulocytic anaplasmosis. Effector Ats-1 is an important virulence factor of A. phagocytophilum. Multiomics screening and validation ha...
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Article
Open AccessA magneto-activated nanoscale cytometry platform for molecular profiling of small extracellular vesicles
Exosomal PD-L1 (exoPD-L1) has recently received significant attention as a biomarker predicting immunotherapeutic responses involving the PD1/PD-L1 pathway. However, current technologies for exosomal analysis ...
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Article
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway
Radiotherapy is the backbone of nasopharyngeal carcinoma (NPC), nearly 11–17% NPC patients suffered local relapse and 18–37% suffered distant metastasis mainly due to radioresistance. Therefore, the key of imp...
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Article
Interface stress relaxation behavior of grouted anchors in red clay: experimental study and a disturbed state concept-based theoretical model
The long-term performance of ground anchors, in particular prestressed anchors, is influenced by the stress relaxation behavior over the soil–anchor interface. The phenomenon of stress relaxation is characteri...
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Article
Creation of an internal electric field in SnO2@ZnS-ZnSn(OH)6 dual-type-II heterojunctions for efficient NO photo-oxidation
Well-designed heterojunction photocatalysts are promising high-performance materials, effective in inducing charge transfer to achieve a particular migration path and long-lasting carriers. However, the tradit...
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Article
Open AccessExpanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse
As a domesticated species vital to humans, horses are raised worldwide as a source of mechanical energy for sports, leisure, food production, and transportation. The gut microbiota plays an important role in t...
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Protocol
Lateral Filter Array Microfluidic Devices for Detecting Circulating Tumor Cells
Circulating tumor cells (CTCs) are an important liquid biopsy biomarker for next-generation cancer diagnosis and prognosis. However, their clinical usage is hindered by the rarity of CTCs in patient’s peripher...
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Protocol
Microfluidics-Enabled Isolation and Single-Cell Analysis of Circulating Tumor Cells
Microfluidic platforms enable the enrichment and analysis of circulating tumor cells (CTCs), a potential biomarker for cancer diagnosis, prognosis, and theragnosis. Combined with immunocytochemistry/immunofluo...
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Article
bta-miR-2904 inhibits bovine viral diarrhea virus replication by targeting viral-infection-induced autophagy via ATG13
MicroRNAs (miRNAs) are endogenous small and noncoding RNA molecules (18–25 nt) that can regulate expression of their target genes post-transcriptionally. Previously, using high-throughput sequencing data obtai...
