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Article
Open AccessEffective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer.
Transgenic animals have become valuable tools for both research and applied purposes. The current method of gene transfer, microinjection, which is widely used in transgenic mouse production, has only had limi...
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Article
Magnetic survey and ChinaGRF 2000
The magnetic survey in China carried out in resent years is briefly introduced. On the basis of the magnetic data at 119 repeat stations, 39 permanent observatories and 20 grid values of the IGRF 2000, the mag...
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Article
Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
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Chapter and Conference Paper
Recognize Color Face Images Using Complex Eigenfaces
A strategy of color image based human face representation is first proposed. Then, based on this representation, complex Eigenfaces technique is developed for facial feature extraction. Finally, we test our id...
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Article
Melatonin-selenium nanoparticles protects liver against immunological injury induced by bacillus Calmette-Guérin and lipopolysaccharide
Melatonin-selenium nanoparticle (MT-Se), a novel complex, was synthesized by preparing selenium nanoparticles in a melatonin medium. The present investigation was designed to determine the protective effects o...
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Article
Open AccessThrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation
Thrombocytopenia is commonly observed in severe leptospirosis. However, previous studies on coagulation alterations during leptospirosis resulted in inconsistent conclusions. Some findings showed that the prom...
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Article
Open AccessThe Reconstruction of Paleovegetation and Paleoclimate in the Late Pliocene of West Yunnan, China
The Eryuan palynoflora from the Late Pliocene of western Yunnan, China is described in this paper, and is compared with two contemporary palynofloras from Yangyi and Longling. The palynological data of the thr...
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Article
Open AccessDoes PGA external stenting reduce compliance mismatch in venous grafts?
Autogenous vein grafting is widely used in regular bypassing procedures. Due to its mismatch with the host artery in both mechanical property and geometry, the graft often over expands under high arterial bloo...
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Article
Open AccessIdentification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma
The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene...
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Article
Apoptosis induced by diallyl disulfide in human breast cancer cell line MCF-7
To investigate the effect of diallyl disulfide (DADS), a component of garlic, on apoptosis in human mammary cancer cell line (MCF-7) and its mechanisms.
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Article
Open AccessCured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: A population based case-control study
Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary r...
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Article
Open AccessA multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis
Chicken type II collagen (CCII) is a protein extracted from the cartilage of chicken breast and exhibits intriguing possibilities for the treatment of autoimmune diseases by inducing oral tolerance. A 24-week,...
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Article
Open AccessThe complete genome of Zunongwangia profunda SM-A87 reveals its adaptation to the deep-sea environment and ecological role in sedimentary organic nitrogen degradation
Zunongwangia profunda SM-A87, which was isolated from deep-sea sediment, is an aerobic, gram-negative bacterium that represents a new genus of Flavobacteriaceae. This is the first sequenced genome of a deep-sea b...
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Article
Preventive effects of 1,25-(OH)2VD3 against ConA-induced mouse hepatitis through promoting vitamin D receptor gene expression
To investigate the immunosuppressive effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2VD3) on concanavalin A (ConA)-induced hepatitis and elucidate the action mechanism.
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Article
Open AccessActivated mammalian target of rapamycin is a potential therapeutic target in gastric cancer
The mammalian target of rapamycin (mTOR) plays a key role in cellular growth and homeostasis. The purpose of our present study is to investigate the expression of activated mTOR (p-mTOR) in gastric cancer pati...
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Chapter and Conference Paper
A Case Study of the Design and Evaluation of a Persuasive Healthy Lifestyle Assistance Technology: Challenges and Design Guidelines
Technology can be used as an intervention of unhealthy lifestyles, but designing such a technology is challenging – usability as well as the ability of changing the user’s behavior needs to be considered. The ...
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Article
Open AccessMicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation
MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in...
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Article
Open AccessAntiangiogenic effects of pazopanib in xenograft hepatocellular carcinoma models: evaluation by quantitative contrast-enhanced ultrasonography
Antiangiogenesis is a promising therapy for advanced hepatocellular carcinoma (HCC), but the effects are difficult to be evaluated. Pazopanib (GW786034B) is a pan-vascular endothelial growth factor receptor in...
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Article
Molecular Diagnosis of Severe Combined Immunodeficiency—Identification of IL2RG, JAK3, IL7R, DCLRE1C, RAG1, and RAG2 Mutations in a Cohort of Chinese and Southeast Asian Children
Severe combined immunodeficiencies (SCID) are a group of rare inherited disorders with profound defects in T cell and B cell immunity. From 2005 to 2010, our unit performed testing for IL2RG, JAK3, IL7R, RAG1, RA...
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Article
CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives
To clarify whether CFTR is a molecular target of intestinal fluid secretion caused by the anthraquinone compounds from laxative herbal plants.
