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Open AccessPulmonary embolism in patients with chronic coronary syndrome masquerading as acute coronary syndrome: a case report and literature review
Pulmonary embolisms (PEs) exhibit clinical features similar to those of acute coronary syndrome (ACS), including electrocardiographic abnormalities and elevated troponin levels, which frequently lead to misdia...
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Article
Open AccessDeep learning model for the prediction of all-cause mortality among long term care people in China: a prospective cohort study
This study aimed to develop a deep learning model to predict the risk stratification of all-cause death for older people with disability, providing guidance for long-term care plans. Based on the government-le...
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Article
Open AccessN6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance
Gemcitabine resistance is a major obstacle to the effectiveness of chemotherapy in pancreatic ductal adenocarcinoma (PDAC). Therefore, new strategies are needed to sensitize cancer cells to gemcitabine. Here, ...
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Article
Open AccessEffects of percutaneous endovascular angioplasty for severe stenosis or occlusion of subclavian artery
To investigate the effect and safety of percutaneous endovascular angioplasty (PEA) with optional stenting for the treatment of severe stenosis or occlusion of subclavian artery, patients with severe stenosis ...
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Article
Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1
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Open AccessTranscutaneous Electrical Acupoint Stimulation Combined with Moderate Sedation of Remimazolam Tosilate in Gastrointestinal Endoscopy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Further clinical validation is required to determine whether transcutaneous electrical acupoint stimulation (TEAS) can replace opioids and be used in combination with remimazolam for sedation during gastrointe...
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Article
Open AccessREEP3 is a potential diagnostic and prognostic biomarker correlated with immune infiltration in pancreatic cancer
Receptor Expression-Enhancing Protein 3 (REEP3) serves as a pivotal enzyme crucial for endoplasmic reticulum (ER) clearance during mitosis and is implicated in the advancement of diverse malignancies. Nonethel...
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Article
Open AccessEffect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway
Previous studies have shown that scutellarin inhibits the excessive activation of microglia, reduces neuronal apoptosis, and exerts neuroprotective effects. However, whether scutellarin regulates activated mic...
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Article
Open AccessConstraining primordial black holes as dark matter using AMS-02 data
Primordial black holes (PBHs) are the plausible candidates for the cosmological dark matter. Theoretically, PBHs with masses $$M_{\textrm{PBH}...
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Article
Open AccessA comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common primary liver cancer with a high incidence and mortality. Members of the growth-arresting-specific 2 (GAS2) family are involved in various biological processes in hum...
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Open AccessAuthor Correction: PPARγ regulates osteoarthritis chondrocytes apoptosis through caspase-3 dependent mitochondrial pathway
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Open AccessRealization of monolayer ZrTe5 topological insulators with wide band gaps
Two-dimensional topological insulators hosting the quantum spin Hall effect have application potential in dissipationless electronics. To observe the quantum spin Hall effect at elevated temperatures, a wide b...
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Article
Open AccessIntrauterine chilled saline instillation reduces endometrial impairment on MRI after ultrasound-guided percutaneous microwave ablation of uterine adenomyosis
To investigate whether intrauterine chilled saline can reduce endometrial impairment during US-guided percutaneous microwave ablation (PMWA) of adenomyosis.
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Article
Open AccessRobustness of design flood estimates under nonstationary conditions: parameter sensitivity perspective
The changing frequency of flooding in global watersheds, driven by various human and natural factors like land use/cover changes and global warming, necessitates innovative approaches in flood frequency analys...
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Article
Open AccessImproved analysis of double \(J/\psi \) production in Z-boson decay
In this paper, we present an improved calculation for the decay rate of the rare Z-boson decay into \(J/\psi + J/\psi .\) ...
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Open AccessDetection and diagnosis of automated breast ultrasound in patients with BI-RADS category 4 microcalcifications: a retrospective study
Automated Breast Ultrasound (AB US) has shown good application value and prospects in breast disease screening and diagnosis. The aim of the study was to explore the ability of AB US to detect and diagnose mam...
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Open AccessThe selective sponging of miRNAs by OIP5-AS1 regulates metabolic reprogramming of pyruvate in adenoma-carcinoma transition of human colorectal cancer
RNA interactomes and their diversified functionalities have recently benefited from critical methodological advances leading to a paradigm shift from a conventional conception on the regulatory roles of RNA in...
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Open AccessEnhancing the biosynthesis of taxadien-5α-yl-acetate in Escherichia coli by combinatorial metabolic engineering approaches
Biosynthesis of paclitaxel (Taxol™) is a hot topic with extensive and durable interests for decades. However, it is severely hindered due to the very low titers of intermediates. In this study, Escherichia coli w...
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Article
Open AccessPPARγ regulates osteoarthritis chondrocytes apoptosis through caspase-3 dependent mitochondrial pathway
Osteoarthritis (OA) is the most prevalent form of arthritis, characterized by a complex pathogenesis. One of the key factors contributing to its development is the apoptosis of chondrocytes triggered by oxidat...
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Article
Open AccessSignificance of atherosclerotic plaque location in recanalizing non-acute long-segment occlusion of the internal carotid artery
To investigate the significance of atherosclerotic plaque location in hybrid surgery comprising both endovascular recanalization approaches and carotid endarterectomy for symptomatic atherosclerotic non-acute ...
