57 Result(s)

Article

Down-regulation of KLRB1 is associated with increased cell growth, metastasis, poor prognosis, as well as a dysfunctional immune microenvironment in LUAD

Killer cell lectin-like receptor B1 (KLRB1) is implicated in cancer progression and immunity. In this study, we aimed to evaluate the expression levels of KLRB1 in lung adenocarcinoma (LUAD) and analyze the re...

Jiu-Ling Chen, Chuang-Yan Wu, **ang-Yu Luo, Xue-Ying Wang… in Scientific Reports (2024)

Article

Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory ph...

Han-Yi Chen, Wan-Chen Hsieh, Yu-Chieh Liu, Huei-Ying Li, Po-Yo Liu… in Nature Communications (2024)

Article

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes^1,2 and molecular mechanisms that are often specific to cell type^3,4. Here, to characterize the genetic c...

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor… in Nature (2024)

Article

Ultracold field-linked tetratomic molecules

Ultracold polyatomic molecules offer opportunities¹ in cold chemistry^2,3, precision measurements⁴ and quantum information processing^5,6, because of their rich internal structure. However, their increased complexi...

**ng-Yan Chen, Shrestha Biswas, Sebastian Eppelt, Andreas Schindewolf, Fulin Deng… in Nature (2024)

Article

Photosensitizer-free visible-light-promoted glycosylation enabled by 2-glycosyloxy tropone donors

Photochemical glycosylation has attracted considerable attention in carbohydrate chemistry. However, to the best of our knowledge, visible-light-promoted glycosylation via photoactive glycosyl donor has not be...

**g Zhang, Zhao-**ang Luo, **a Wu, Chen-Fei Gao, Peng-Yu Wang… in Nature Communications (2023)

Article

Identification and validation of candidate clinical signatures of apolipoprotein L isoforms in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a lethal malignancy worldwide with an increasing number of new cases each year. Apolipoprotein (APOL) isoforms have been explored for their associations with HCC.The GSE14520 ...

**ang-Kun Wang, Yu-**ang Guo, Miao Wang, Xu-Dong Zhang… in Scientific Reports (2023)

Article

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets

Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that FSH and FSHR play important roles in extragonadal tissue. H...

Yi Cheng, Hong Zhu, Jun Ren, Hai-Yan Wu, Jia-En Yu, Lu-Yang **… in Nature Communications (2023)

Article

Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion

Cell migration plays important roles in many biological processes, but how migrating cells orchestrate intracellular molecules and subcellular structures to regulate their speed and direction is still not clea...

Chao Jiang, Hong-Yu Luo, **npeng Xu, Shuo-**ng Dou, Wei Li… in Nature Communications (2023)

Article

A high-temperature double perovskite molecule-based antiferroelectric with excellent anti-breakdown capacity for energy storage

Halide double perovskites have recently emerged as an environmentally green candidate toward electronic and optoelectronic applications owing to their non-toxicity and versatile physical merits, whereas study ...

Yi Liu, Yu Ma, ** Zeng, Haojie Xu, Wuqian Guo, Beibei Wang… in Nature Communications (2023)

Article

Field-linked resonances of polar molecules

Scattering resonances are an essential tool for controlling the interactions of ultracold atoms and molecules. However, conventional Feshbach scattering resonances¹, which have been extensively studied in various...

**ng-Yan Chen, Andreas Schindewolf, Sebastian Eppelt, Roman Bause, Marcel Duda… in Nature (2023)

Article

Effect of FXR agonist GW4064 in the treatment of hilar cholangiocarcinoma in rats

The study objective was to observe the treatment effect of the farnesoid X receptor (FXR) agonist GW4064 in a rat model of hilar cholangiocarcinoma to explore a new therapeutic target for gene therapy for hila...

Jie-** Wang, Meng-yu Zhang, Ming Luo, Shu Qin, **an-ming **a in Scientific Reports (2022)

Article

Effects of mesenchymal stem cells in renovascular disease of preclinical and clinical studies: a systematic review and meta-analysis

Renal artery stenosis (RAS) causes severe renovascular hypertension, worsening kidney function, and increased cardiovascular morbidity. According to recent studies, mesenchymal stem cells (MSCs) administration...

Hong-Shen Wang, Ming-Yu Yi, ** Wu, Qian Liu, Ying-Hao Deng, Ting Wu… in Scientific Reports (2022)

Article

Integrated biosensor platform based on graphene transistor arrays for real-time high-accuracy ion sensing

Two-dimensional materials such as graphene have shown great promise as biosensors, but suffer from large device-to-device variation due to non-uniform material synthesis and device fabrication technologies. He...

Mantian Xue, Charles Mackin, Wei-Hung Weng, Jiadi Zhu, Yiyue Luo… in Nature Communications (2022)

Article

Evaporation of microwave-shielded polar molecules to quantum degeneracy

Ultracold polar molecules offer strong electric dipole moments and rich internal structure, which makes them ideal building blocks to explore exotic quantum matter^1–9, implement quantum information schemes^10–12 a...

Andreas Schindewolf, Roman Bause, **ng-Yan Chen, Marcel Duda, Tijs Karman… in Nature (2022)

Article

FXR expression in rats of hilar cholangiocarcinoma

The study objective was to detect the expression of farnesoid X receptor (FXR) in a rat model of hilar cholangiocarcinoma to provide a new therapeutic target for gene therapy in hilar cholangiocarcinoma. Sixty...

Meng-yu Zhang, Ming Luo, Jie-** Wang in Scientific Reports (2022)

Article

Author Correction: Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP

Mi-bo Tang, Yu-sheng Li, Shao-hua Li, Yuan Cheng, Shuo Zhang… in Scientific Reports (2021)

Article

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in targeting the pathway ...

Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon… in Nature Communications (2021)

Article

Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. The mechanisms underlying ASD are unclear. Astrocyte alterations are noted in ASD patients and animal models. However, whether astrocyte ...

Qian Wang, Ying Kong, Ding-Yu Wu, Ji-Hong Liu, Wei Jie… in Nature Communications (2021)

Article

Arbuscular mycorrhizal trees influence the latitudinal beta-diversity gradient of tree communities in forests worldwide

Arbuscular mycorrhizal (AM) and ectomycorrhizal (EcM) associations are critical for host-tree performance. However, how mycorrhizal associations correlate with the latitudinal tree beta-diversity remains untes...

Yonglin Zhong, Cheng** Chu, Jonathan A. Myers, Gregory S. Gilbert… in Nature Communications (2021)