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MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells

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  1. Article

    Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury

    Interleukin-1 beta (IL-β) has been implicated as an extracellular signal in the initiation of apoptosis in neurons and oligodendrocytes after spinal cord injury (SCI). To further characterize the apoptotic cas...

    **n-jia Wang, Kang-mei Kong, Wei-li Qi, Wei-lian Ye… in Acta Pharmacologica Sinica (2005)

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  2. Article

    LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1

    Glomerular endothelial cell (GEC) injury plays an important role in the early stage of diabetic nephropathy (DN). Previous studies show that a PKCβ inhibitor is effective for treating DN. In the current study ...

    Zhi-bin Wang, Su Zhang, Ya Li, Rong-mei Wang, Ling-chang Tong… in Acta Pharmacologica Sinica (2017)

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