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Open AccessThe rise of baobab trees in Madagascar
The baobab trees (genus Adansonia) have attracted tremendous attention because of their striking shape and distinctive relationships with fauna1. These spectacular trees have also influenced human culture, inspir...
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Article
Open AccessDeep learning and ultrasound feature fusion model predicts the malignancy of complex cystic and solid breast nodules with color Doppler images
This study aimed to evaluate the performance of traditional-deep learning combination model based on Doppler ultrasound for diagnosing malignant complex cystic and solid breast nodules. A conventional statisti...
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Article
Open AccessAtomic-scale manipulation of single-polaron in a two-dimensional semiconductor
Polaron is a composite quasiparticle derived from an excess carrier trapped by local lattice distortion, and it has been studied extensively for decades both theoretically and experimentally. However, atomic-s...
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Article
Open AccessWAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour
The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates m...
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Open AccessEffects of Bushen-Tiao**g-Fang on the pregnancy outcomes of infertile patients with repeated controlled ovarian stimulation
Bushen-Tiao**g-Fang (BSTJF) is commonly used to treat infertility. This study investigated the effects of BSTJF on the pregnancy outcomes of patients with repeated controlled ovarian stimulation (COS), on mit...
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Article
Open AccessCorrelation of bone density to screw loosening in dynamic stabilization: an analysis of 176 patients
Although osteoporosis has negative impacts on lumbar fusion, its effects on screw loosening in dynamic stabilization remain elusive. We aimed to correlate bone mineral density (BMD) with screw loosening in Dyn...
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Article
Open AccessBoosting photoelectrochemical efficiency by near-infrared-active lattice-matched morphological heterojunctions
Photoelectrochemical catalysis is an attractive way to provide direct hydrogen production from solar energy. However, solar conversion efficiencies are hindered by the fact that light harvesting has so far bee...
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Article
Open Accessα-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation
Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule functio...
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Article
Open AccessSingle-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
Fibrotic skin disease represents a major global healthcare burden, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts are found to be heterogeneous i...
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Article
Open AccessThe risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study
Since iron is essential for neurotransmitter synthesis, decreased iron stores might lead to reduced production of biogenic amines which phenomenon was shown in Fibromyalgia (FM) patients. The aims are to inves...
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Open AccessProfiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
Numerous substrates have been identified for Type I and II arginine methyltransferases (PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its connection to type I and II PRMT s...
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Article
Open AccessNanoscale redox map** at the MoS2-liquid interface
Layered MoS2 is considered as one of the most promising two-dimensional photocatalytic materials for hydrogen evolution and water splitting; however, the electronic structure at the MoS2-liquid interface is so fa...
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Article
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
N6-methyladenosine (m6A), the most prevalent internal RNA modification on mammalian messenger RNAs, regulates the fates and functions of modified transcripts through m6A-specific binding proteins1–5. In the nervo...
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Article
Open AccessIdentification of small-molecule ion channel modulators in C. elegans channelopathy models
Ion channels are important therapeutic targets, but the discovery of ion channel drugs remains challenging due to a lack of assays that allow high-throughput screening in the physiological context. Here we rep...
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Open AccessAuthor Correction: Diagnostic value of ultrasound features and sex of fetuses in female patients with papillary thyroid microcarcinoma
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-cell RNA-sequencing (scRN...
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Open AccessDiagnostic value of ultrasound features and sex of fetuses in female patients with papillary thyroid microcarcinoma
Little work has been done on the prediction of papillary thyroid microcarcinoma in female patients who have given birth to children, which may be different from other people. We performed a retrospective revie...
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Article
Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health 1 . Bats have been recognized as one of the most important reservoirs for emerging v...
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Article
Open AccessConstruction of hierarchically porous metal–organic frameworks through linker labilization
A major goal of metal–organic framework (MOF) research is the expansion of pore size and volume. Although many approaches have been attempted to increase the pore size of MOF materials, it is still a challenge...
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Open AccessPhylogeographical structure and demographic expansion in the endemic alpine stream salamander (Hynobiidae: Batrachuperus) of the Qinling Mountains
The Qinling Mountains of China provide an excellent study area for assessing the effect of Pleistocene climatic oscillations and paleogeological events on intraspecific diversification. To assess genetic diver...