30 Result(s)

Article

Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury

Neural progenitor cells (NPCs) derived from human pluripotent stem cells(hPSCs) provide major cell sources for repairing damaged neural circuitry and enabling axonal regeneration after spinal cord injury (SCI)...

Yong-Long Chen, **ang-Lan Feng, Kin-Wai Tam, Chao-Yang Fan… in npj Regenerative Medicine (2024)

Article

Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

The success of messenger RNA therapeutics largely depends on the availability of delivery systems that enable the safe, effective and stable translation of genetic material into functional proteins. Here we sh...

Yi You, Yu Tian, Zhaogang Yang, Junfeng Shi… in Nature Biomedical Engineering (2023)

Article

Proteomic analysis of exosome-like vesicles from Fasciola gigantica adult worm provides support for new vaccine targets against fascioliasis

Extracellular vesicles (EVs) released by helminths play an important role in parasite-host communication. However, little is known about the characteristics and contents of the EVs of Fasciola gigantica, a paras...

Zhao-An Sheng, Cui-Lan Wu, Dong-Ying Wang, Shu-Hong Zhong, ** Yang… in Parasites & Vectors (2023)

Article

SYT-SSX1 enhances the invasiveness and maintains stem-like cell properties in synovial sarcoma via induction of TGF-β1/Smad signaling

Synovial sarcoma (SS) is a type of soft tissue sarcoma (STS) of undetermined tissue origin, which is characterized by the recurrent pathognomonic chromosomal translocation t (X;18)(p11.2; q11.2). Studies have ...

Yan Qi, Shuang-Shuang Dong, Yong-Lai He, Zi-Han Liu, Ya-Lan Huang, Ning Wang… in BMC Cancer (2022)

Article

The gut microbiome and antibiotic resistome of chronic diarrhea rhesus macaques (Macaca mulatta) and its similarity to the human gut microbiome

Chronic diarrhea is a common disease causing morbidity and mortality of captive rhesus macaques (RMs, Macaca mulatta). Chronic diarrhea in RMs is typically characterized by long-term diarrhea and a weak response ...

Shengzhi Yang, Yu Liu, Nan Yang, Yue Lan, Weiqi Lan, **yi Feng, Bisong Yue… in Microbiome (2022)

Article

Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p

More and more studies have shown that circular RNAs (circRNAs) play a critical regulatory role in many cancers. However, the potential molecular mechanism of circRNAs in prostate cancer (PCa) remains largely u...

Yu-Zhong Yu, Dao-Jun Lv, Chong Wang, **an-Lu Song, Tao **e, Tao Wang… in Molecular Cancer (2022)

Article

Two divergent haplotypes from a highly heterozygous lychee genome suggest independent domestication events for early and late-maturing cultivars

Lychee is an exotic tropical fruit with a distinct flavor. The genome of cultivar ‘Feizixiao’ was assembled into 15 pseudochromosomes, totaling ~470 Mb. High heterozygosity (2.27%) resulted in two complete hap...

Guibing Hu, Junting Feng, Xu **ang, Jiabao Wang, Jarkko Salojärvi… in Nature Genetics (2022)

Article

A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation

Constitutive activation of nuclear factor-κB (NF-κB) signaling plays a key role in the development and progression of colorectal carcinoma (CRC). However, the underlying mechanisms of excessive activation of N...

Zhen-xing Liang, Hua-shan Liu, Li **ong, **n Yang, Feng-wei Wang… in Molecular Cancer (2021)

Article

Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: “Adenovirus Vaccine Within an Adenovirus Vector”

Human adenoviruses (HAdVs) are highly contagious and result in large number of acute respiratory disease (ARD) cases with severe morbidity and mortality. Human adenovirus type 3 (HAdV-3) is the most common typ...

Yuqian Yan, Shu** **g, Liqiang Feng, **g Zhang, Zhiwei Zeng… in Virologica Sinica (2021)

Article

Brief report of the first cured 2019-nCoV pneumonia patient in West China Hospital

En-Qiang Chen, Li-Chun Wang, Guang-Min Tang… in European Journal of Clinical Microbiology … (2020)

Article

Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies

Epidemiological studies on the association between coffee intake and cancer risk have yielded inconsistent results. To summarize and appraise the quality of the current evidence, we conducted an umbrella revie...

Long-Gang Zhao, Zhuo-Ying Li, Guo-Shan Feng, **ao-Wei Ji, Yu-Ting Tan… in BMC Cancer (2020)

Article

Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas

N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential tumor suppressor in lung cancer and explored its molecular mech...

**gshu Wang, Kun Zou, Xu Feng, Miao Chen, Cong Li, Ranran Tang… in Molecular Cancer (2017)

Article

Clinical and molecular characteristics, risk factors and outcomes of Carbapenem-resistant Klebsiella pneumoniae bloodstream infections in the intensive care unit

To analyze the clinical characteristics and outcomes of carbapenem-resistant Klebsiella pneumoniae (CRKp) and carbapenem-susceptible K. pneumoniae (CSKp) bloodstream infections (BSIs), and to study the risk facto...

**a Zheng, Jian-feng Wang, Wang-lan Xu… in Antimicrobial Resistance & Infection Contr… (2017)

Article

Disparities of time trends and birth cohort effects on invasive breast cancer incidence in Shanghai and Hong Kong pre- and post-menopausal women

Breast cancer is the leading cause of cancer morbidity among Shanghai and Hong Kong women, which contributes to 20–25% of new female cancer incidents. This study aimed to describe the temporal trend of breast ...

Feng Wang, Lap Ah Tse, Wing-cheong Chan, Carol Chi-hei Kwok, Siu-lan Leung… in BMC Cancer (2017)

Article

Nighttime eating and breast cancer among Chinese women in Hong Kong

A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits aft...

Mengjie Li, Lap Ah Tse, Wing-cheong Chan, Chi-hei Kwok… in Breast Cancer Research (2017)

Article

20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway

Our preliminary study shows that a bibenzyl compound isolated from Gastrodia elata, 2-[4-hydroxy-3-(4-hydroxybenzyl)benzyl]-4-(4-hydroxybenzyl)phenol (designated 20C), protects PC12 cells against H₂O₂-induced inj...

Ju-yang Huang, Yu-he Yuan, Jia-qing Yan, Ya-nan Wang… in Acta Pharmacologica Sinica (2016)

Article

Epigenetic regulation of CDH1 exon 8 alternative splicing in gastric cancer

The tumor suppressor gene CDH1 is critical for intercellular adhesion. In our previous work, we reported a nonfunctional CDH1 transcript that lacks the final 83 base pairs of exon 8 (1054del83). In this work, we ...

**ao-Wei Li, Bing-Yu Shi, Qing-Lan Yang, Jie Wu, Hui-Min Wu, Yu-Feng Wang… in BMC Cancer (2015)

Article

Isoflavones and phytosterols contained in Xuezhikang capsules modulate cholesterol homeostasis in high-fat diet mice

Xuezhikang (XZK), an extract of red yeast rice, has been widely used in traditional Chinese medicine to treat cardiovascular disease. Three fractions F1, F2 and F3 (primarily containing isoflavones, monacolins...

Dong Feng, Jian-guo Sun, Run-bin Sun, Bing-chen Ou-Yang… in Acta Pharmacologica Sinica (2015)

Article

Alterative effects of an oral alginate extract on experimental rabbit osteoarthritis

Osteoarthritis (OA) is a common joint disease that causes disabilities in elderly. However, few agents with high efficacy and low side effects have been developed to treat OA. In this study, we evaluated the e...

Hsien-Tseng Lu, Ming-Shium Hsieh, Chao-Wen Cheng… in Journal of Biomedical Science (2015)

Article

2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

Sterol-regulatory element binding proteins (SREBPs) are major transcription factors that regulate liver lipid biosynthesis. In this article we reported a novel synthetic compound 2-(3-benzoylthioureido)-4,5,6,...

** Zhang, Li-na Zhang, Dong-mei Chen, Yan-yun Fu, Feng Zhang… in Acta Pharmacologica Sinica (2015)