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  1. Article

    Open Access

    A Phase 3, Randomized, Controlled Trial Evaluating the Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Moderate COVID-19

    Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon. This clinical study aimed to evaluate its antiviral efficacy of ropeginterferon alfa-2b against SARS-CoV-2 infection.

    Wang-Da Liu, Po-Hao Feng, Chien-Yu Cheng in Infectious Diseases and Therapy (2024)

  2. Article

    Open Access

    Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan

    Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with ...

    Wen-Chien Cheng, Chia-Ling Chang, Chau-Chyun Sheu in European Journal of Medical Research (2024)

  3. Article

    Open Access

    Identification and coregulation pattern analysis of long noncoding RNAs in the mouse brain after Angiostrongylus cantonensis infection

    Angiostrongyliasis is a highly dangerous infectious disease. Angiostrongylus cantonensis larvae migrate to the mouse brain and cause symptoms, such as brain swelling and bleeding. Noncoding RNAs (ncRNAs) are nove...

    Dong-Hui Cheng, Tian-Ge Jiang, Wen-Bo Zeng, Tian-Mei Li, Yi-Dan **g in Parasites & Vectors (2024)

  4. No Access

    Article

    Integrative multi-omics profiling in human decedents receiving pig heart xenografts

    In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand th...

    Eloi Schmauch, Brian Piening, Maedeh Mohebnasab, Bo **a, Chenchen Zhu in Nature Medicine (2024)

  5. Article

    Open Access

    Towards an actionable One Health approach

    Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Reco...

    **ao-** Zhang, Zohar Lederman, Le-Fei Han in Infectious Diseases of Poverty (2024)

  6. No Access

    Article

    Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial

    Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...

    Feng Wang, Ying **, Min Wang, Hui-Yan Luo, Wei-Jia Fang, Ying-Nan Wang in Nature Medicine (2024)

  7. Article

    Open Access

    Real-time, random-access organ screening for carbapenem-resistant organisms (CRO) reduces CRO-associated, donor-derived infection mortality in lung transplant recipients

    Donor-derived infection (DDI) has become an important factor affecting the prognosis of lung transplantation patients. The risks versus benefits of using donor organs infected with multidrug-resistant organism...

    Wen-Yong Zhou, Lei Shen, Jian-**n Shi, **ng-Hui Gao, Jun Yang, Shi-Jie Fu in Infection (2024)

  8. Article

    Open Access

    Involvement of IL-17 A/IL-17 Receptor A with Neutrophil Recruitment and the Severity of Coronary Arteritis in Kawasaki Disease

    To assess the role of the interleukin (IL)-17 A/IL-17 receptor A (IL-17RA) in Kawasaki disease (KD)-related coronary arteritis (CA).

    I-Chun Lin, Jau-Ling Suen, Shau-Ku Huang, Ming-Hui Chou in Journal of Clinical Immunology (2024)

  9. Article

    Open Access

    Sciatica caused by spinal epidural abscess as the initial clinical presentation of colon cancer: a rare case report and review of literature

    Colorectal cancer is one of the most frequently diagnosed forms of cancer, and it is associated with several common symptoms and signs such as rectal bleeding, altered bowel habits, abdominal pain, anemia, and...

    Kuan-Yu Lu, Wei-En Tung, Chang-Jung Chiang, Yueh-Ying Hsieh in BMC Infectious Diseases (2024)

  10. Article

    Open Access

    Immune persistence after different polio sequential immunization schedules in Chinese infants

    Trivalent oral poliovirus vaccine (tOPV) has been withdrawn and instead an inactivated poliovirus vaccine (IPV) and bivalent type 1 and type 3 OPV (bOPV) sequential immunization schedule has been implemented s...

    Ting Zhao, **g Li, Teng Huang, Zhi-Fang Ying, Yan-Chun Che, Zhi-Mei Zhao in npj Vaccines (2024)

  11. Article

    Open Access

    The optimal blood glucose is significantly associated with lower mortality in critically ill patients with cardiogenic shock: an analysis revealed with time series blood glucose records

    The optimal blood glucose (BG) level for patients with cardiogenic shock in the intensive care unit (ICU) remains unclear. Studies have found that both excessively high and low BG levels contribute to adverse ...

    Ce Sun, Ji-Hong Zhou, Yan-Ling Huang, Yi-Le Ning in European Journal of Medical Research (2024)

  12. Article

    Open Access

    Procalcitonin and C-reactive protein as diagnostic biomarkers in COVID-19 and Non-COVID-19 sepsis patients: a comparative study

    This study aimed to assess and compare procalcitonin (PCT) and C-reactive protein (CRP) levels between COVID-19 and non-COVID-19 sepsis patients. Additionally, we evaluated the diagnostic efficiency of PCT and...

    **g Shi, Ying Zhuo, Ting-Qiang Wang, Chun-E Lv, Ling-Hui Yao in BMC Infectious Diseases (2024)

  13. Article

    Open Access

    Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study

    Neurological disorders are still prevalent in HIV-infected people. We aimed to determine the prevalence of neurological disorders and identify their risk factors in HIV-infected persons in Taiwan.

    Ya-Wei Weng, Susan Shin-Jung Lee, Hung-Chin Tsai, Chih-Hui Hsu in BMC Infectious Diseases (2023)

  14. Article

    Open Access

    Prevalence and genomic analysis of t203-like G9 (G9-VI) rotaviruses circulating in children with gastroenteritis in Bei**g, China

    Our previous surveillance revealed that t203-like G9 (tentatively designated subtype G9-VI) rotaviruses re-emerged in 2010 in Bei**g and rapidly prevailed over the G9-III subtype (the most common G9 subtype g...

    Hui-** Dong, Li-Ying Liu, Li-** Jia, Lin-Qing Zhao, Feng-Hua ** in Archives of Virology (2023)

  15. Article

    Open Access

    Tackling barriers to scale up human papillomavirus vaccination in China: progress and the way forward

    The human papillomavirus (HPV) vaccine is the first vaccine developed specifically targeting the prevention of cervical cancer. For more than 15 years, China has expedited a series of efforts on research and d...

    Xue-Lian Zhao, Shang-Ying Hu, Jia-Wei Hu, Hong-Hao Wang in Infectious Diseases of Poverty (2023)

  16. No Access

    Article

    The Aging Biomarker Consortium represents a new era for aging research in China

    Jie Ren, Moshi Song, Weiqi Zhang, Jian-** Cai, Feng Cao, Zhongwei Cao in Nature Medicine (2023)

  17. Article

    Open Access

    Safety and efficacy of enterprise stenting for symptomatic atherosclerotic severe posterior circulation stenosis

    To investigate the safety and efficacy of Enterprise stent angioplasty and risk factors for the prognoses in treating symptomatic severe posterior circulation atherosclerotic stenosis (SSPCAS).

    Zhi-Long Zhou, Tian-**ao Li, Liang-Fu Zhu in European Journal of Medical Research (2023)

  18. Article

    Open Access

    Psittacosis caused severe community-acquired pneumonia accompanied by acute hypoxic respiratory failure: a multicenter retrospective cohort study from China

    Psittacosis can cause severe community-acquired pneumonia (CAP). The clinical manifestations of psittacosis range from subclinical to fulminant psittacosis with multi-organ failure. It is essential to summariz...

    **ao Tang, Na Wang, Gang Liu, Hai Tan, Ai-Min Li, Yan-Qiu Gao in BMC Infectious Diseases (2023)

  19. Article

    Open Access

    Tackling global health security by building an academic community for One Health action

    One Health approach is crucial to tackling complex global public health threats at the interface of humans, animals, and the environment. As outlined in the One Health Joint Plan of Action, the international O...

    **ao-** Zhang, **n-Chen Li, Qi-Yu Zhang, **g-Shu Liu in Infectious Diseases of Poverty (2023)

  20. Article

    Open Access

    Comparisons of perioperative and long-term outcomes of laparoscopic versus open gastrectomy for advanced gastric cancer after neoadjuvant therapy: an updated pooled analysis of eighteen studies

    Outcomes of laparoscopic surgery in advanced gastric cancer patients who received neoadjuvant therapy represent a controversial issue. We performed an updated meta-analysis to evaluate the perioperative and lo...

    Hua-Yang Pang, **u-Feng Chen, Li-Hui Chen in European Journal of Medical Research (2023)

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