196 Result(s)
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Article
Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells
To examine the effect of venom from the spider Macrothele raven on cell proliferation and cytotoxicity in human cervical carcinoma, HeLa cells.
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Article
ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats
To determine whether ONO-1078 (pranlukast), a potent cysteinyl leukotriene receptor 1 (CysLT1) antagonist, has an effect on N-methyl-D-aspartate (NMDA)-induced brain injury and vascular cell adhesion molecule-1 (...
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Article
Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration
To investigate the effect of 7-hydroxystaurosporine (UCN-01), a selective protein kinase C (PKC) inhibitor, on cell growth, migration, and invasion in invasive human glioblastoma U-87MG cells.
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Article
Characterization of Anti-Mesangial Cell Antibodies and Their Target Antigens in Patients with Lupus Nephritis
The pathogenetic mechanisms of lupus nephritis (LN) remain to be elucidated. In our previous study, autoantibodies against human glomerular mesangial cells (HMC) were identified in sera of most patients with l...
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Article
Infectious Tolerance to ADP/ATP Carrier Peptides Induced by Anti-L3T4 Monoclonal Antibody in Dilated Cardiomyopathy Mice
CD4 T cells are suspected to play an important role in the pathogenesis of dilated cardiomyopathy (DCM). This study sought to evaluate whether anti-L3T4 monoclonal antibody (McAb) could induce the infectious t...
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Article
Design, synthesis, and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives
To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent an...
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Article
Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts
To examine the effect of daidzin, genistin, and glycitin on the osteogenic and adipogenic differentiation of bone marrow stromal cells (MSC) and the adipogenic transdifferentiation of osteoblasts.
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Article
Enhancement of binding activity of soluble human CD40 to CD40 ligand through incorporation of an isoleucine zipper motif
To investigate the effect of incorporation of an isoleucine zipper (IZ) motif into CD40 on binding activity of CD40 for the CD40 ligand (CD40L).
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Article
Non-DNA-Binding Antibodies in Patients with Lupus Nephritis Could Recognize Membrane Proteins of Glomerular Mesangial Cells
Lupus nephritis (LN) is a prototypic autoimmune disease, however, the precise immuno-pathogenesis of LN remains to be elucidated. In our previous studies, autoantibodies against mesangial cells had been identi...
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Article
Aquaporins as potential drug targets
The aquaporins (AQP) are a family of integral membrane proteins that selectively transport water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen mammalian AQP have been molecularl...
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Article
Deguelin inhibits expression of IκBα protein in Raji and U937 cells
To determine whether deguelin can regulate the expression of nuclear factor kappa B (NF-κB) binding protein (IκBα) in U937 human leukemia cells and Raji human B lymphoma cells.
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Article
MEK inhibitor PD98059 acutely inhibits synchronized spontaneous Ca2+ oscillations in cultured hippocampal networks
To investigate the changes in synchronized spontaneous Ca2+ oscillations induced by mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 at different concentrations in cultured hippocampal network.
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Article
Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and develo** therapies
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, which is caused by an abnormal expansion of Cytosine Adenine Guanine (CAG) trinucleotide repeat in the gene making huntingtin (Htt...
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Article
Solute Carrier Family 11 Member A1 Gene Polymorphisms in Reactive Arthritis
To investigate the role of SLC 11A1 polymorphisms in the development of reactive arthritis, 91 patients with reactive arthritis and 163 healthy controls were enrolled in this study. The SLC 11A1 polymorphisms wer...
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Article
Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells
To investigate the role of crotoxin (CrTX)-induced autophagy in the death of MCF-7 cells, a caspase-3-deficient, human breast cancer cell line.
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Article
Molecular cloning and characterization of a cytosolic heat shock protein 70 from Naegleria fowleri
A gene encoding a cytosolic heat shock protein 70 from pathogenic Naegleria fowleri (Nf-cHSP70) was identified. The Nf-cHSP70 was 2,062 bp in length with an open reading frame of 1,980 bp encoding 659 amino acid ...
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Article
Effects of gestrinone on uterine leiomyoma and expression of c-Src in a guinea pig model
To investigate the effect of gestrinone on uterine leiomyomas and the expression of c-Src, estradiol receptors (ER), and progesterone receptors (PR) in a guinea pig model.
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Article
Detection and analysis of bovine foamy virus infection by an indicator cell line
To determine the infectivity and replication strategy of bovine foamy virus (BFV) in different cultured cells using the BFV indicator cell line (BICL) system.
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Article
Dihydroartemisinin is an inhibitor of ovarian cancer cell growth
To investigate the anticancer activity of dihydroartemisinin (DHA), a derivative of antimalaria drug artemisinin in a panel of human ovarian cancer cell lines.
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Article
Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia
To investigate the effects of lithium (Li) and prostaglandin A1 (PGA1) on the expression of heat shock factor 1 (HSF-1), heat shock proteins (HSP), and apoptosis protease activating factor-1 (Apaf-1) induced by p...
