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  1. Article

    Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells

    To examine the effect of venom from the spider Macrothele raven on cell proliferation and cytotoxicity in human cervical carcinoma, HeLa cells.

    Li Gao, Bao-en Shan, **g Chen, Jiang-hui Liu, Da-xiang Song in Acta Pharmacologica Sinica (2005)

  2. Article

    ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats

    To determine whether ONO-1078 (pranlukast), a potent cysteinyl leukotriene receptor 1 (CysLT1) antagonist, has an effect on N-methyl-D-aspartate (NMDA)-induced brain injury and vascular cell adhesion molecule-1 (...

    Li-hui Zhang, Er-qing Wei in Acta Pharmacologica Sinica (2005)

  3. Article

    Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration

    To investigate the effect of 7-hydroxystaurosporine (UCN-01), a selective protein kinase C (PKC) inhibitor, on cell growth, migration, and invasion in invasive human glioblastoma U-87MG cells.

    Qing-hui Meng, Li-xin Zhou, Jia-lin Luo, Jian-** Cao in Acta Pharmacologica Sinica (2005)

  4. Article

    Design, synthesis, and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives

    To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent an...

    Ming-hui Li, Lin-lin Yin, Mao-jun Cai, Wei-yu Zhang in Acta Pharmacologica Sinica (2005)

  5. Article

    Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts

    To examine the effect of daidzin, genistin, and glycitin on the osteogenic and adipogenic differentiation of bone marrow stromal cells (MSC) and the adipogenic transdifferentiation of osteoblasts.

    **ang-hui Li, **-chao Zhang, Sen-fang Sui, Meng-su Yang in Acta Pharmacologica Sinica (2005)

  6. Article

    Enhancement of binding activity of soluble human CD40 to CD40 ligand through incorporation of an isoleucine zipper motif

    To investigate the effect of incorporation of an isoleucine zipper (IZ) motif into CD40 on binding activity of CD40 for the CD40 ligand (CD40L).

    **an-hui He, Li-hui Xu, Yi Liu in Acta Pharmacologica Sinica (2006)

  7. Article

    Aquaporins as potential drug targets

    The aquaporins (AQP) are a family of integral membrane proteins that selectively transport water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen mammalian AQP have been molecularl...

    Fang Wang, Xue-chao Feng, Yong-ming Li, Hong Yang in Acta Pharmacologica Sinica (2006)

  8. Article

    Deguelin inhibits expression of IκBα protein in Raji and U937 cells

    To determine whether deguelin can regulate the expression of nuclear factor kappa B (NF-κB) binding protein (IκBα) in U937 human leukemia cells and Raji human B lymphoma cells.

    Wei-hua Chen, Yan Chen, Guo-hui Cui in Acta Pharmacologica Sinica (2006)

  9. Article

    MEK inhibitor PD98059 acutely inhibits synchronized spontaneous Ca2+ oscillations in cultured hippocampal networks

    To investigate the changes in synchronized spontaneous Ca2+ oscillations induced by mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 at different concentrations in cultured hippocampal network.

    Yan-fang Rui, Zhao-hui Sun, Jia-** Gu, Zhong-hua Sheng in Acta Pharmacologica Sinica (2006)

  10. Article

    Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and develo** therapies

    Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, which is caused by an abnormal expansion of Cytosine Adenine Guanine (CAG) trinucleotide repeat in the gene making huntingtin (Htt...

    Lin-hui Wang, Zheng-hong Qin in Acta Pharmacologica Sinica (2006)

  11. Article

    Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells

    To investigate the role of crotoxin (CrTX)-induced autophagy in the death of MCF-7 cells, a caspase-3-deficient, human breast cancer cell line.

    Ci-hui Yan, Ya-** Yang, Zheng-hong Qin, Zhen-lun Gu in Acta Pharmacologica Sinica (2007)

  12. Article

    Effects of gestrinone on uterine leiomyoma and expression of c-Src in a guinea pig model

    To investigate the effect of gestrinone on uterine leiomyomas and the expression of c-Src, estradiol receptors (ER), and progesterone receptors (PR) in a guinea pig model.

    Yan Zhu, **ao-yan Qiu, Lei Wang, Jian-hui Wu, Gui-ming Liu in Acta Pharmacologica Sinica (2007)

  13. Article

    Detection and analysis of bovine foamy virus infection by an indicator cell line

    To determine the infectivity and replication strategy of bovine foamy virus (BFV) in different cultured cells using the BFV indicator cell line (BICL) system.

    Zhe Ma, Wen-tao Qiao, Cheng-hao Xuan, **-hui **e in Acta Pharmacologica Sinica (2007)

  14. Article

    Dihydroartemisinin is an inhibitor of ovarian cancer cell growth

    To investigate the anticancer activity of dihydroartemisinin (DHA), a derivative of antimalaria drug artemisinin in a panel of human ovarian cancer cell lines.

    Yang Jiao, Chun-min Ge, Qing-hui Meng, Jian-** Cao in Acta Pharmacologica Sinica (2007)

  15. Article

    Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia

    To investigate the effects of lithium (Li) and prostaglandin A1 (PGA1) on the expression of heat shock factor 1 (HSF-1), heat shock proteins (HSP), and apoptosis protease activating factor-1 (Apaf-1) induced by p...

    **-hui Xu, Yi-nan Hua, Hui-ling Zhang, Jun-chao Wu in Acta Pharmacologica Sinica (2007)

  16. Article

    Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent

    To seek a novel and potent antitussive drug based on Shedan—Chuanbei powder, a complex of traditional Chinese medicine preparation for cough therapy.

    Fang-zhou Xu, Chang Chen, Yong-hui Zhang, Han-li Ruan in Acta Pharmacologica Sinica (2007)

  17. Article

    Adenovirus-mediated expression of Tob1 sensitizes breast cancer cells to ionizing radiation1

    To investigate the effect of the Tob1 gene, a member of the Transducing Molecule of ErbB2/B-cell Translocation Ggene (TOB/BTG) family, by using the adenovirus-mediated expression of Tob1 on radiosensitivity in...

    Yang Jiao, Chun-min Ge, Qing-hui Meng, Jian-** Cao in Acta Pharmacologica Sinica (2007)

  18. Article

    Preoperative growth inhibition of human gastric adenocarcinoma treated with a combination of celecoxib and octreotide

    To gain insight into the histopathological responses and molecular targets in the inhibition of growth of human gastric cancer treated with celecoxib (a cyclooxygenase [COX]-2 inhibitor) combined with octreotide.

    Mao-tao Huang, Zhi-xin Chen, Bing Wei, Bo Zhang in Acta Pharmacologica Sinica (2007)

  19. Article

    Structure-based drug design of a novel family of chalcones as PPARα agonists: virtual screening, synthesis, and biological activities in vitro

    To design and synthesize a novel class of peroxisome proliferator-activated receptors (PPAR)α agonists, which is obtained by the combination of the classical fibrate “head group”, a linker with appropriate len...

    **ang-hua Li, Han-jun Zou, An-hui Wu, Yang-liang Ye in Acta Pharmacologica Sinica (2007)

  20. Article

    Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation

    The aim of this study was to investigate the effects of aloe-emodin, a natural compound from the root and rhizome of Rheum palmatum, on the growth of human cervical cancer cells, HeLa.

    Jun-ming Guo, Bing-xiu **ao, Qiong Liu, Shun Zhang in Acta Pharmacologica Sinica (2007)

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