82 Result(s)
within
**ang-De Li
Science, Humanities and Social Sciences, multidisciplinary
English
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMyricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson’s disease
Ferroptosis is an iron-dependent cell death form characterized by reactive oxygen species (ROS) overgeneration and lipid peroxidation. Myricetin, a flavonoid that exists in numerous plants, exhibits potent ant...
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Open AccessArea postrema neurons mediate interleukin-6 function in cancer cachexia
Interleukin-6 (IL-6) has been long considered a key player in cancer cachexia. It is believed that sustained elevation of IL-6 production during cancer progression causes brain dysfunctions, which ultimately r...
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Open AccessEfficient intersystem crossing and tunable ultralong organic room-temperature phosphorescence via do** polyvinylpyrrolidone with polyaromatic hydrocarbons
Polymer-based pure organic room-temperature phosphorescent materials have tremendous advantages in applications owing to their low cost, vast resources, and easy processability. However, designing polymer-base...
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Open AccessNucleic-acid-base photofunctional cocrystal for information security and antimicrobial applications
Cocrystal engineering is an efficient and simple strategy to construct functional materials, especially for the exploitation of novel and multifunctional materials. Herein, we report two kinds of nucleic-acid-...
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Open AccessAn organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome
Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, hormone si...
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Article
Open AccessSialoglycan binding triggers spike opening in a human coronavirus
Coronavirus spike proteins mediate receptor binding and membrane fusion, making them prime targets for neutralizing antibodies. In the cases of severe acute respiratory syndrome coronavirus, severe acute respi...
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Article
Open AccessMutation of key signaling regulators of cerebrovascular development in vein of Galen malformations
To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common and most severe of congenital brain arteriovenous malformations, we performed an integrated analysis of 310 VOGM proband-fa...
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Open AccessMetafiber transforming arbitrarily structured light
Structured light has proven useful for numerous photonic applications. However, the current use of structured light in optical fiber science and technology is severely limited by mode mixing or by the lack of ...
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Open AccessSpinal afferent innervation in flat-mounts of the rat stomach: anterograde tracing
The dorsal root ganglia (DRG) project spinal afferent axons to the stomach. However, the distribution and morphology of spinal afferent axons in the stomach have not been well characterized. In this study, we ...
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Open AccessDiploid and tetraploid genomes of Acorus and the evolution of monocots
Monocots are a major taxon within flowering plants, have unique morphological traits, and show an extraordinary diversity in lifestyle. To improve our understanding of monocot origin and evolution, we generate...
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Article
Open AccessChina can be self-sufficient in maize production by 2030 with optimal crop management
Population growth and economic development in China has increased the demand for food and animal feed, raising questions regarding China’s future maize production self-sufficiency. Here, we address this challe...
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Open AccessGigahertz optoacoustic vibration in Sub-5 nm tip-supported nano-optomechanical metasurface
The gigahertz acoustic vibration of nano-optomechanical systems plays an indispensable role in all-optical manipulation of light, quantum control of mechanical modes, on-chip data processing, and optomechanica...
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Article
Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis
Medulloblastoma (MB) is the most common malignant childhood brain tumour1,2, yet the origin of the most aggressive subgroup-3 form remains elusive, impeding development of effective targeted treatments. Previous ...
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Open AccessA multicentre single arm phase 2 trial of neoadjuvant pyrotinib and letrozole plus dalpiciclib for triple-positive breast cancer
Current therapies for HER2-positive breast cancer have limited efficacy in patients with triple-positive breast cancer (TPBC). We conduct a multi-center single-arm phase 2 trial to test the efficacy and safety...
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Open AccessDeep phenoty** and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value beca...
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Open AccessOptoelectronic properties and ultrafast carrier dynamics of copper iodide thin films
As a promising high mobility p-type wide bandgap semiconductor, copper iodide has received increasing attention in recent years. However, the defect physics/evolution are still controversial, and particularly ...
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Open AccessGABB: A global dataset of alpine breeding birds and their ecological traits
Alpine ecosystems represent varied climates and vegetation structures globally, with the potential to support rich and functionally diverse avian communities. High mountain habitats and species are under signi...
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Open AccessA consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations
Decades of rodent research have established the role of hippocampal sharp wave ripples (SPW-Rs) in consolidating and guiding experience. More recently, intracranial recordings in humans have suggested their ro...
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Open AccessTraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy
ER-mitochondrial contact sites (EMCSs) are important for mitochondrial function. Here, we have identified a EMCS complex, comprising a family of uncharacterised mitochondrial outer membrane proteins, TRB1, TRB...
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Open AccessLong read genome assemblies complemented by single cell RNA-sequencing reveal genetic and cellular mechanisms underlying the adaptive evolution of yak
Wild yak (Bos mutus) and domestic yak (Bos grunniens) are adapted to high altitude environment and have ecological, economic, and cultural significances on the Qinghai-Tibetan Plateau (QTP). Currently, the geneti...
