39 Result(s)
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Open AccessMetabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder
Classical metabolomic and new metabolic network methods were used to study the developmental features of autism spectrum disorder (ASD) in newborns (n = 205) and 5-year-old children (n = 53). Eighty percent of th...
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Metagenomic analysis of individual mosquito viromes reveals the geographical patterns and drivers of viral diversity
Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a ...
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Open AccessComparative and phylogenetic analysis of Chiloschista (Orchidaceae) species and DNA barcoding investigation based on plastid genomes
Chiloschista (Orchidaceae, Aeridinae) is an epiphytic leafless orchid that is mainly distributed in tropical or subtropical forest canopies. This rare and threatened orchid lacks molecular resources for phylogene...
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A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases
Cross-kingdom herbal miRNA was first reported in 2012. Using a modified herbal extraction protocol, we obtained 73,677,287 sequences by RNA-seq from 245 traditional Chinese Medicine (TCM), of which 20,758,257 ...
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Plastid-localized amino acid metabolism coordinates rice ammonium tolerance and nitrogen use efficiency
Ammonium toxicity affecting plant metabolism and development is a worldwide problem impeding crop production. Remarkably, rice (Oryza sativa L.) favours ammonium as its major nitrogen source in paddy fields. We s...
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Open AccessGeneration of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
The α7 nicotinic acetylcholine receptor (nAChR), a potential drug target for treating cognitive disorders, mediates communication between neuronal and non-neuronal cells. Although many competitive antagonists,...
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Open AccessA proteome-scale map of the SARS-CoV-2–human contactome
Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity to efficiently design therapies for emerging virus variants remains an urgent challenge of the ongoing pandemic. Infection a...
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The genome of homosporous maidenhair fern sheds light on the euphyllophyte evolution and defences
Euphyllophytes encompass almost all extant plants, including two sister clades, ferns and seed plants. Decoding genomes of ferns is the key to deep insight into the origin of euphyllophytes and the evolution o...
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Open AccessModulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role...
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Pelagic cyanobacterial nitrogen fixation in lakes and ponds of different latitudinal zones
Excess nitrogen (N) loading is one of the main factors causing eutrophication. Biological N fixation (BNF), as a main contributor to N loading, plays a critical role in the N cycle. The N2 fixation rate (N2fix) i...
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Sparse deconvolution improves the resolution of live-cell super-resolution fluorescence microscopy
A main determinant of the spatial resolution of live-cell super-resolution (SR) microscopes is the maximum photon flux that can be collected. To further increase the effective resolution for a given photon flu...
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Open AccessGenomes of leafy and leafless Platanthera orchids illuminate the evolution of mycoheterotrophy
To improve our understanding of the origin and evolution of mycoheterotrophic plants, we here present the chromosome-scale genome assemblies of two sibling orchid species: partially mycoheterotrophic Platanthera ...
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Open AccessT cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we demonstrate that T cells expressing TCRs specific fo...
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FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance
How cancer cells adapt to evade the therapeutic effects of drugs targeting oncogenic drivers is poorly understood. Here we report an epigenetic mechanism leading to the adaptive resistance of triple-negative b...
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Open AccessWolfberry genomes and the evolution of Lycium (Solanaceae)
Wolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although seve...
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Dissecting the initiation of female meiosis in the mouse at single-cell resolution
Meiosis is one of the most finely orchestrated events during gametogenesis with distinct developmental patterns in males and females. However, the molecular mechanisms involved in this process remain not well ...
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Genome-wide association study identifies 48 common genetic variants associated with handedness
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and t...
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Open AccessRoadmap for naming uncultivated Archaea and Bacteria
The assembly of single-amplified genomes (SAGs) and metagenome-assembled genomes (MAGs) has led to a surge in genome-based discoveries of members affiliated with Archaea and Bacteria, bringing with it a need t...
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Two new species of Encyrtidae (Hymenoptera: Chalcidoidea) from China, parasitoid of Antecerococcus roseus (Green) (Hemiptera: Cerococcidae) on Boehmeria nivea (L.) Gaud
Two new species of Encyrtidae (Hymenoptera: Chalcidoidea), Microterys perlucidus Zu sp. nov. and Metaphycus roseus Zu sp. nov., are described from China as parasitoids of Antecerococcus roseus (Green) (Hemiptera:...
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COSY catalyses trans–cis isomerization and lactonization in the biosynthesis of coumarins
Coumarins, also known as 1,2-benzopyrones, comprise a large class of secondary metabolites that are ubiquitously found throughout the plant kingdom. In many plant species, coumarins are particularly important ...
