20,097 Result(s)
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Open AccessAdenine base editing-mediated exon skip** restores dystrophin in humanized Duchenne mouse model
Duchenne muscular dystrophy (DMD) affecting 1 in 3500–5000 live male newborns is the frequently fatal genetic disease resulted from various mutations in DMD gene encoding dystrophin protein. About 70% of DMD-caus...
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Open AccessOverview of clinical status, treatment, and long-term outcomes of pediatric autosomal-dominant polycystic kidney disease: a nationwide survey in Taiwan
This retrospective study investigated the incidence, medication use, and outcomes in pediatric autosomal-dominant polycystic kidney disease (ADPKD) using Taiwan's National Health Insurance Research Database (N...
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Open AccessLarge-scale 2D heterostructures from hydrogen-bonded organic frameworks and graphene with distinct Dirac and flat bands
The current strategies for building 2D organic-inorganic heterojunctions involve mostly wet-chemistry processes or exfoliation and transfer, leading to interface contaminations, poor crystallizing, or limited ...
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Open AccessDiscovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility
Eunicellane diterpenoids, containing a typical 6,10-bicycle, are bioactive compounds widely present in marine corals, but rarely found in bacteria and plants. The intrinsic macrocycle exhibits innate structura...
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Open Access18F-FDG PET/CT metabolic parameters can semi-quantitatively evaluate the nature of the heart and pericardial masses: a retrospective study
The objective of this study was to evaluate semi-quantitatively the diagnostic performance of PET/CT metabolic parameters in differentiating benign or malignant cardiac or pericardial masses. A total of forty-...
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Open AccessLegionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms
The intracellular bacterial pathogen Legionella pneumophila modulates host cell functions by secreting multiple effectors with diverse biochemical activities. In particular, effectors of the SidE family interfere...
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Open AccessStructure characteristics and combustion kinetics of the co-pyrolytic char of rice straw and coal gangue
Co-combustion is a technology that enables the simultaneous and efficient utilization of biomass and coal gangue (CG). Nevertheless, the factors that affect the combustibility of co-pyrolytic char, which repre...
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Open AccessRobust structural superlubricity under gigapascal pressures
Structural superlubricity (SSL) is a state of contact with no wear and ultralow friction. SSL has been characterized at contact with van der Waals (vdW) layered materials, while its stability under extreme loa...
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Open AccessRecommendations for managing adult acne and adolescent acne based on an epidemiological study conducted in China
There are numerous differences between adult acne and adolescent acne in terms of causes, distribution, and characteristics of skin lesions, as well as treatment. This paper aims to summarize the differences b...
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Open AccessThe impact of tertiary lymphoid structures on tumor prognosis and the immune microenvironment in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a common malignancy whose prognosis and treatment outcome are influenced by many factors. Some studies have found that tertiary lymphoid structures (TLSs) in cancer may co...
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Open AccessExceptional figure of merit achieved in boron-dispersed GeTe-based thermoelectric composites
GeTe is a promising p-type material with increasingly enhanced thermoelectric properties reported in recent years, demonstrating its superiority for mid-temperature applications. In this work, the thermoelectr...
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Open AccessEvaporate-casting of curvature gradient graphene superstructures for ultra-high strength structural materials
In contemporary manufacturing, the processing of structural materials plays a pivotal role in enabling the creation of robust, tailor-made, and precise components suitable for diverse industrial applications. ...
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Open AccessAssessing long-term effects of gaseous air pollution exposure on mortality in the United States using a variant of difference-in-differences analysis
Long-term mortality effects of particulate air pollution have been investigated in a causal analytic frame, while causal evidence for associations with gaseous air pollutants remains extensively lacking, espec...
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Open AccessComparative assessment of the capability of machine learning-based radiomic models for predicting omental metastasis in locally advanced gastric cancer
The study aims to investigate the predictive capability of machine learning algorithms for omental metastasis in locally advanced gastric cancer (LAGC) and to compare the performance metrics of various machine...
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Open AccessElucidating the catalytic mechanism of Prussian blue nanozymes with self-increasing catalytic activity
Although Prussian blue nanozymes (PBNZ) are widely applied in various fields, their catalytic mechanisms remain elusive. Here, we investigate the long-term catalytic performance of PBNZ as peroxidase (POD) and...
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Open AccessContact-electro-catalytic CO2 reduction from ambient air
Traditional catalytic techniques often encounter obstacles in the search for sustainable solutions for converting CO2 into value-added products because of their high energy consumption and expensive catalysts. He...
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Open AccessElectron stochastic acceleration in laboratory-produced kinetic turbulent plasmas
The origin of energetic charged particles in universe remains an unresolved issue. Astronomical observations combined with simulations have provided insights into particle acceleration mechanisms, including ma...
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Open AccessChromosome-level genome assembly of Hippophae rhamnoides variety
Fructus hippophae (Hippophae rhamnoides spp. mongolica×Hippophae rhamnoides sinensis), a hybrid variety of sea buckthorn that Hippophae rhamnoides spp. mongolica serves as the female parent and Hippophae rhamnoid...
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Open AccessEnhanced electrocatalytic biomass oxidation at low voltage by Ni2+-O-Pd interfaces
Challenges in direct catalytic oxidation of biomass-derived aldehyde and alcohol into acid with high activity and selectivity hinder the widespread biomass application. Herein, we demonstrate that a Pd/Ni(OH)2 ca...
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Open AccessA strategy for tough and fatigue-resistant hydrogels via loose cross-linking and dense dehydration-induced entanglements
Outstanding overall mechanical properties are essential for the successful utilization of hydrogels in advanced applications such as human-machine interfaces and soft robotics. However, conventional hydrogels ...
