21 Result(s)
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Article
Open AccessTargeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2
Soft-tissue sarcomas (STS) emerges as formidable challenges in clinics due to the complex genetic heterogeneity, high rates of local recurrence and metastasis. Exploring specific targets and biomarkers would b...
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Open AccessUric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation
Excessive uric acid (UA) is associated with age-related cataract. A previous study showed that a high UA level in the aqueous humor stimulated the senescence of lens epithelial cells (LECs), leading to catarac...
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Open AccessCOVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan
The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by ...
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Open AccessLoss of LXN promotes macrophage M2 polarization and PD-L2 expression contributing cancer immune-escape in mice
Latexin (LXN) plays an important role in tumorigenesis and inflammatory response and as a tumor suppressor in many tumors. However, whether LXN regulates tumorigenesis through immune regulation remains uncerta...
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Article
Open AccessRole of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress
The basis of orthodontic tooth movement (OTM) is the reconstruction of periodontal tissue under stress. Increasing the speed of OTM has always been the focus of attention.
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Open AccessExosomes from mmu_circ_0001052-modified adipose-derived stem cells promote angiogenesis of DFU via miR-106a-5p and FGF4/p38MAPK pathway
Diabetic foot ulcer (DFU) is a chronic infectious disease caused by diabetes mellitus (DM). Angiogenesis plays the decisive role in wound healing of DFU. Adipose-derived stem cells (ADSCs) can ameliorate angio...
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Open AccessLatexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet
Obesity is a risk factor for many chronic diseases, and is associated with increased incidence rate of type 2 diabetes, hypertension, dyslipidemia and cardiovascular diseases. Adipocyte differentiation play cr...
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Article
Open AccessSuppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury
Cisplatin, a highly effective and widely used chemotherapeutic agent, has a major limitation for its nephrotoxicity. Currently, there are no therapies available to treat or prevent cisplatin nephrotoxicity. We...
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Article
Characterization and expression analysis of a chalcone isomerase-like gene in relation to petal color of Actinidia chrysantha
Chalcone isomerase-like (CHIL) belongs to the type IV CHI proteins whose roles in cell remain largely unclear. In the present study, we characterized an AcCHIL gene encoding Actinidia chrysantha CHIL protein. The...
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Distinct expression patterns of the GDP dissociation inhibitor protein gene (OsRhoGDI2) from Oryza sativa during development and abiotic stresses
Guanine nucleotide dissociation inhibitor (GDI) plays an essential role in regulating the forms of Rac/Rop between GDP-bound inactivity and GTP-bound activity in plants. In this paper, we reported a stress-res...
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Article
Role of recombinant plasmid pEGFP-N1-IGF-1 transfection in alleviating osteoporosis in ovariectomized rats
Decreased levels of serum insulin-like growth factor-1 (IGF-1) have been proven to cause osteoporosis. Gene transfer of IGF-1 offers an attractive technology to treat skeletal metabolic disorders including ost...
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Article
Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia/reperfusion in both humans and rats
Previous studies indicate aging results in significantly decreased cardiac function and increased myocardial apoptosis after myocardial ischemia/reperfusion (MI/R) in humans or rats. The underlying mechanisms ...
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Article
2-(3,5-Dibromo-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthrolinoruthenium(II) complexes: synthesis, characterization, cytotoxicity, apoptosis, DNA-binding and antioxidant activity
A new ligand DBHIP and its two ruthenium(II) complexes [Ru(dmb)2(DBHIP)](ClO4)2 (1) and [Ru(dmp)2(DBHIP)](ClO4)2 (2) have been synthesized and characterized. The cytotoxicity of DBHIP and complexes 1 and 2 has be...
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Article
Open AccessAdenoviral oncoprotein E1B55K mediates colocalization of SSBP2 and PML in response to stress
Transient expression of adenoviral oncoprotein E1B55K in normal cells induces aggresome formation and sequestration of critical host proteins in aggresomes. Our previous studies reported that Sequence Specific...
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Article
Mycotoxin Ochratoxin A-induced cell death and changes in oxidative metabolism of Arabidopsis thaliana
We evaluated the phytotoxicity of mycotoxin ochratoxin A (OTA) from Aspergillus and Penicillium strains on Arabidopsis thaliana. The results demonstrate that the growth of Arabidopsis thaliana on media containing...
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Article
GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth
Here, we report the identification of GIDE, a mitochondrially located E3 ubiquitin ligase. GIDE contains a C-terminal RING finger domain, which is mostly conserved with those of the IAP family members and is r...
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Article
Effect of heparin on apoptosis in human nasopharyngeal carcinoma CNE2 cells
In order to study the mechanism of the effect of heparin on apoptosis in carcinoma cells, the nasopharyngeal carcinoma cell line CNE2 was used to identify the effect of heparin on apoptosis associated with the...
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Article
Effect of pH and Zn2+ on subcultured muscle cells from Macrobrachium nipponense
A cell culture system was devised for muscle cell of Macrobrachium nipponense in the study. The juvenile and adult shrimps were held in laboratory aquaria with penicillin 1000 IU/ml and streptomycin 1000 µg/ml fo...
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Mitotic reversion in prophase of PTK1 cells induced by argon laser microirradiation
In this paper, we report the effects of laser microirradiation of prophase nucleoli and mitotic chromosomes in cells of female rat kangaroo kidney epithelial cell line PTK1. When the laser power delivered to samp...
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Study on mechanism of micronucleoli formation by laser microirradiation
In the male rat kangaroo cell line PTK2, argon laser (514.5 nm) microirradiation of both nucleoli in interphase cells 30, 23, and 12 h before mitosis, and nucleoli in early prophase cells resulted in the formatio...
