112 Result(s)

Article

Impact of LDLR polymorphisms on lipid levels and atorvastatin’s efficacy in a northern Chinese adult Han cohort with dyslipidemia

Dyslipidemia, a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), is influenced by genetic variations, particularly those in the low-density lipoprotein receptor (LDLR) gene. This stu...

Hong-Liang Zhao, Yang You, Yan Tian, Luyan Wang… in Lipids in Health and Disease (2024)

Article

Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2

Soft-tissue sarcomas (STS) emerges as formidable challenges in clinics due to the complex genetic heterogeneity, high rates of local recurrence and metastasis. Exploring specific targets and biomarkers would b...

Mingzhi Zhuang, Fengyue Li, Hong Liang, Yongfu Su, Lei Cheng… in Cell Death & Disease (2024)

Article

Uric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation

Excessive uric acid (UA) is associated with age-related cataract. A previous study showed that a high UA level in the aqueous humor stimulated the senescence of lens epithelial cells (LECs), leading to catarac...

Hong Liang Lin, Sheng Wang, Kota Sato, Yu Qiao Zhang, Bei Ting He… in Cell Death Discovery (2024)

Article

MOCAT: multi-omics integration with auxiliary classifiers enhanced autoencoder

Integrating multi-omics data is emerging as a critical approach in enhancing our understanding of complex diseases. Innovative computational methods capable of managing high-dimensional and heterogeneous datas...

**aohui Yao, **aohan Jiang, Haoran Luo, Hong Liang, **ufen Ye, Yanhui Wei… in BioData Mining (2024)

Article

Correction to: Mediative Mechanism of Freezing/Thawing on Greenhouse Gas Emissions in an Inland Saline Alkaline Wetland: a Metagenomic Analysis

Yupeng Zhang, Fengqin Liu, Hong Liang, Dawen Gao in Microbial Ecology (2023)

Article

COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan

The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by ...

Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu… in Cell Discovery (2022)

Article

Loss of LXN promotes macrophage M2 polarization and PD-L2 expression contributing cancer immune-escape in mice

Latexin (LXN) plays an important role in tumorigenesis and inflammatory response and as a tumor suppressor in many tumors. However, whether LXN regulates tumorigenesis through immune regulation remains uncerta...

Ya** Li, Yanhui Tan, **uZhen Li, Xuanming Chen, Lingzhu Wang… in Cell Death Discovery (2022)

Article

Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress

The basis of orthodontic tooth movement (OTM) is the reconstruction of periodontal tissue under stress. Increasing the speed of OTM has always been the focus of attention.

Li Wang, Hong Liang, Bing**g Sun, **g Mi, **anqin Tong… in Stem Cell Research & Therapy (2022)

Article

Exosomes from mmu_circ_0001052-modified adipose-derived stem cells promote angiogenesis of DFU via miR-106a-5p and FGF4/p38MAPK pathway

Diabetic foot ulcer (DFU) is a chronic infectious disease caused by diabetes mellitus (DM). Angiogenesis plays the decisive role in wound healing of DFU. Adipose-derived stem cells (ADSCs) can ameliorate angio...

Zun-Hong Liang, Nan-Fang Pan, Shi-Shuai Lin, Zhi-Yang Qiu… in Stem Cell Research & Therapy (2022)

Article

Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet

Obesity is a risk factor for many chronic diseases, and is associated with increased incidence rate of type 2 diabetes, hypertension, dyslipidemia and cardiovascular diseases. Adipocyte differentiation play cr...

Shuang Kan, Rong Li, Yanhui Tan, Fang Yang, Shaohua Xu… in Cell Death & Disease (2022)

Article

Complete genome sequence of the kiwifruit bacterial canker pathogen Pseudomonas savastanoi strain MHT1

Pseudomonas savastanoi is an important plant pathogen that infects and causes symptoms in a variety of economically important crops, causing considerable loss of yield and quality. Because there has been no rese...

Mingzhao Zhong, Yunhao Sun, **anzhi Zhang, Hong Liang, Lina **ong… in BMC Microbiology (2022)

Article

Genome-wide variant-based study of genetic effects with the largest neuroanatomic coverage

Brain image genetics provides enormous opportunities for examining the effects of genetic variations on the brain. Many studies have shown that the structure, function, and abnormality (e.g., those related to ...

** Li, Wenjie Liu, Huang Li, Feng Chen, Haoran Luo, Peihua Bao… in BMC Bioinformatics (2021)