26 Result(s)

Article

RETRACTED ARTICLE: HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development

Macrophages can be reprogramming, such as the classical activated macrophage, M1 or alternative activated macrophages, M2 phenotype following the milieu danger signals, especially inflammatory factors. Macroph...

Zhaoliang Su, Pan Zhang, Ying Yu, Hongxiang Lu, Yanfang Liu, ** Ni… in Scientific Reports (2016)

Article

Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides

Multicellular spheroids of cancer cells have been increasingly used to screen anti-tumor compounds, owing to their in vivo like microenvironment and structure as well as compatibility to high-throughput/high-cont...

Jixia Wang, **uli Zhang, **aolong Li, Yun Zhang, Tao Hou, Lai Wei… in Scientific Reports (2016)

Article

Aptamer-PEG-modified Fe₃O₄@Mn as a novel T1- and T2- dual-model MRI contrast agent targeting hypoxia-induced cancer stem cells

Hypoxia-induced cancer stem cells have been known to be involved in tumour metastasis, resistance to chemo/radio therapy and tumour recurrence. Magnetic Resonance Imaging is a widely used imaging tool for canc...

Haitao Zhu, Lirong Zhang, Yanfang Liu, Yuepeng Zhou, Kang Wang… in Scientific Reports (2016)

Article

Discovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica

Scopolia tangutica (S. tangutica) is a traditional Chinese medicinal plant used for antispasmodics, anesthesia, analgesia and sedation. Its pharmacological activities are mostly associated with the antagonistic a...

Nana Du, Yanfang Liu, **uli Zhang, Jixia Wang, Jianqiang Zhao… in Scientific Reports (2017)

Article

Association between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis

Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke and H-type hypertension, which is defined as hypertension with hyperhomocysteinemia, is associated with cardio-cerebrovas...

Jia Zhang, Yanfang Liu, Anxin Wang, Dandan Wang, Ruixuan Jiang… in Scientific Reports (2018)

Article

Three-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography

Scaffolded DNA origami has proven to be a powerful and efficient technique to fabricate functional nanomachines by programming the folding of a single-stranded DNA template strand into three-dimensional (3D) n...

Dongsheng Lei, Alexander E. Marras, Jianfang Liu, Chao-Min Huang… in Nature Communications (2018)

Article

An Algorithm for Enhancing the Image Contrast of Electron Tomography

Three-dimensional (3D) reconstruction of a single protein molecule is essential for understanding the relationship between the structural dynamics and functions of the protein. Electron tomography (ET) provide...

Hao Wu, **aobo Zhai, Dongsheng Lei, Jianfang Liu, Yadong Yu… in Scientific Reports (2018)

Article

PCA-PAM50 improves consistency between breast cancer intrinsic and clinical subty** reclassifying a subset of luminal A tumors as luminal B

The PAM50 classifier is widely used for breast tumor intrinsic subty** based on gene expression. Clinical subty**, however, is based on immunohistochemistry assays of 3–4 biomarkers. Subtype calls by these...

Praveen-Kumar Raj-Kumar, Jianfang Liu, Jeffrey A. Hooke… in Scientific Reports (2019)

Article

Single-Molecule 3D Images of “Hole-Hole” IgG1 Homodimers by Individual-Particle Electron Tomography

The engineering of immunoglobulin-G molecules (IgGs) is of wide interest for improving therapeutics, for example by modulating the activity or multiplexing the specificity of IgGs to recognize more than one an...

Dongsheng Lei, Jianfang Liu, Hongbin Liu, Thomas E. Cleveland IV… in Scientific Reports (2019)

Article

The integration of metabolome and proteome reveals bioactive polyphenols and hispidin in ARTP mutagenized Phellinus baumii

Phellinus baumii, also called “Sang Huang” in China, is broadly used as a kind of health food or folk medicine in Asia for its high biological activities, e.g. anti-tumor, anti-oxidation and anti-inflammatory act...

Henan Zhang, Ruibing Chen, **gsong Zhang, Qitao Bu, Wenhan Wang… in Scientific Reports (2019)

Article

LoTToR: An Algorithm for Missing-Wedge Correction of the Low-Tilt Tomographic 3D Reconstruction of a Single-Molecule Structure

A single-molecule three-dimensional (3D) structure is essential for understanding the thermal vibrations and dynamics as well as the conformational changes during the chemical reaction of macromolecules. Indiv...

**aobo Zhai, Dongsheng Lei, Meng Zhang, Jianfang Liu, Hao Wu… in Scientific Reports (2020)

Article

Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia

The mutational spectrum and prognostic factors of NRAS-mutated (NRAS^mut) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovere...

Shujuan Wang, Zhenzhen Wu, Tao Li, Yafei Li, Weiqiong Wang… in Scientific Reports (2020)

Article

Is the risk of second primary malignancy increased in multiple myeloma in the novel therapy era? A population-based, retrospective cohort study in Taiwan

Longer survival in patients with multiple myeloma (MM) after treatment with novel agents (NA) such as thalidomide, bortezomib, and lenalidomide may be associated with increased risks of develo** second prima...

Yanfang Liu, Hsin-An Hou, Hong Qiu, Chao-Hsiun Tang in Scientific Reports (2020)

Article

Treatment pathways and disease journeys differ before and after introduction of novel agents in newly diagnosed multiple myeloma in Taiwan

Limited real-world data are available regarding treatment practices and outcomes of multiple myeloma (MM) in Asia. We conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Resea...

Yanfang Liu, Chao-Hsiun Tang, Hong Qiu, Sarah Siggins, Hsin-An Hou in Scientific Reports (2021)

Article

A comprehensive retrospective cohort study of the journey of B-cell lymphoma in Taiwan

Complete disease journey and risk factors for poor outcomes are needed to facilitate effectiveness evaluations of new therapies and clinical decision-making in B-cell Non-Hodgkin lymphoma (B-NHL), particularly...

Sung-Nan Pei, Ming-Chung Wang, Ming-Chun Ma, Ching-Yuan Kuo… in Scientific Reports (2021)

Article

Designed and biologically active protein lattices

Versatile methods to organize proteins in space are required to enable complex biomaterials, engineered biomolecular scaffolds, cell-free biology, and hybrid nanoscale systems. Here, we demonstrate how the tai...

Shih-Ting Wang, Brian Minevich, Jianfang Liu, Honghu Zhang… in Nature Communications (2021)

Article

Retraction Note: HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development

Zhaoliang Su, Pan Zhang, Ying Yu, Hongxiang Lu, Yanfang Liu, ** Ni… in Scientific Reports (2022)

Article

Memory load differentially influences younger and older users’ learning curve of touchscreen gestures

In this study, we employed a recall test to investigate how memory load affects the learning curve of gesture-letter pairs for younger and older users. The gesture-letter pairs were carefully designed to mimic...

Bingxin Li, Tong Yang, Yanfang Liu, Feng Du in Scientific Reports (2022)

Article

A population-based cohort study of the epidemiology of light-chain amyloidosis in Taiwan

The incidence rate of AL (light-chain) amyloidosis is not known in Asia. We conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Research database and Death Registry to estimat...

Hsin-An Hou, Chao-Hsiun Tang, Choo Hua Goh, Shih-Pei Shen… in Scientific Reports (2022)