26 Result(s)
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Open AccessAngle between DNA linker and nucleosome core particle regulates array compaction revealed by individual-particle cryo-electron tomography
The conformational dynamics of nucleosome arrays generate a diverse spectrum of microscopic states, posing challenges to their structural determination. Leveraging cryogenic electron tomography (cryo-ET), we d...
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Open AccessSelective production of methylindan and tetralin with xylose or hemicellulose
Indan and tetralin are widely used as fuel additives and the intermediates in the manufacture of thermal-stable jet fuel, many chemicals, medicines, and shockproof agents for rubber industry. Herein, we disclo...
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Open AccessImpact of industrial robots on environmental pollution: evidence from China
The application of industrial robots is considered a significant factor affecting environmental pollution. Selecting industrial wastewater discharge, industrial SO2 emissions and industrial soot emissions as the ...
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Open AccessCharacteristics and risk of interstitial lung disease in dermatomyositis and polymyositis: a retrospective cohort study in Japan
Dermatomyositis and polymyositis are rare, idiopathic inflammatory myopathies. Interstitial lung disease is one of the most common and potentially severe extra-muscular manifestations of dermatomyositis and po...
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Open AccessFacile hermetic TEM grid preparation for molecular imaging of hydrated biological samples at room temperature
Although structures of vitrified supramolecular complexes have been determined at near-atomic resolution, elucidating in situ molecular structure in living cells remains a challenge. Here, we report a straight...
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Open-channel metal particle superlattices
Although tremendous advances have been made in preparing porous crystals from molecular precursors1,2, there are no general ways of designing and making topologically diversified porous colloidal crystals over th...
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Open AccessA population-based cohort study of the epidemiology of light-chain amyloidosis in Taiwan
The incidence rate of AL (light-chain) amyloidosis is not known in Asia. We conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Research database and Death Registry to estimat...
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Strong yet ductile nanolamellar high-entropy alloys by additive manufacturing
Additive manufacturing produces net-shaped components layer by layer for engineering applications1–7. The additive manufacture of metal alloys by laser powder bed fusion (L-PBF) involves large temperature gradien...
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Open AccessMemory load differentially influences younger and older users’ learning curve of touchscreen gestures
In this study, we employed a recall test to investigate how memory load affects the learning curve of gesture-letter pairs for younger and older users. The gesture-letter pairs were carefully designed to mimic...
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Open AccessRetraction Note: HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development
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Open AccessDesigned and biologically active protein lattices
Versatile methods to organize proteins in space are required to enable complex biomaterials, engineered biomolecular scaffolds, cell-free biology, and hybrid nanoscale systems. Here, we demonstrate how the tai...
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Open AccessA comprehensive retrospective cohort study of the journey of B-cell lymphoma in Taiwan
Complete disease journey and risk factors for poor outcomes are needed to facilitate effectiveness evaluations of new therapies and clinical decision-making in B-cell Non-Hodgkin lymphoma (B-NHL), particularly...
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Open AccessTreatment pathways and disease journeys differ before and after introduction of novel agents in newly diagnosed multiple myeloma in Taiwan
Limited real-world data are available regarding treatment practices and outcomes of multiple myeloma (MM) in Asia. We conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Resea...
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Open AccessIs the risk of second primary malignancy increased in multiple myeloma in the novel therapy era? A population-based, retrospective cohort study in Taiwan
Longer survival in patients with multiple myeloma (MM) after treatment with novel agents (NA) such as thalidomide, bortezomib, and lenalidomide may be associated with increased risks of develo** second prima...
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Open AccessMutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia
The mutational spectrum and prognostic factors of NRAS-mutated (NRASmut) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovere...
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Open AccessLoTToR: An Algorithm for Missing-Wedge Correction of the Low-Tilt Tomographic 3D Reconstruction of a Single-Molecule Structure
A single-molecule three-dimensional (3D) structure is essential for understanding the thermal vibrations and dynamics as well as the conformational changes during the chemical reaction of macromolecules. Indiv...
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Open AccessThe integration of metabolome and proteome reveals bioactive polyphenols and hispidin in ARTP mutagenized Phellinus baumii
Phellinus baumii, also called “Sang Huang” in China, is broadly used as a kind of health food or folk medicine in Asia for its high biological activities, e.g. anti-tumor, anti-oxidation and anti-inflammatory act...
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Open AccessSingle-Molecule 3D Images of “Hole-Hole” IgG1 Homodimers by Individual-Particle Electron Tomography
The engineering of immunoglobulin-G molecules (IgGs) is of wide interest for improving therapeutics, for example by modulating the activity or multiplexing the specificity of IgGs to recognize more than one an...
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Open AccessPCA-PAM50 improves consistency between breast cancer intrinsic and clinical subty** reclassifying a subset of luminal A tumors as luminal B
The PAM50 classifier is widely used for breast tumor intrinsic subty** based on gene expression. Clinical subty**, however, is based on immunohistochemistry assays of 3–4 biomarkers. Subtype calls by these...
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Open AccessAn Algorithm for Enhancing the Image Contrast of Electron Tomography
Three-dimensional (3D) reconstruction of a single protein molecule is essential for understanding the relationship between the structural dynamics and functions of the protein. Electron tomography (ET) provide...
