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Open AccessRETRACTED ARTICLE: HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development
Macrophages can be reprogramming, such as the classical activated macrophage, M1 or alternative activated macrophages, M2 phenotype following the milieu danger signals, especially inflammatory factors. Macroph...
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Article
Open AccessAnti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides
Multicellular spheroids of cancer cells have been increasingly used to screen anti-tumor compounds, owing to their in vivo like microenvironment and structure as well as compatibility to high-throughput/high-cont...
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Article
Open AccessAptamer-PEG-modified Fe3O4@Mn as a novel T1- and T2- dual-model MRI contrast agent targeting hypoxia-induced cancer stem cells
Hypoxia-induced cancer stem cells have been known to be involved in tumour metastasis, resistance to chemo/radio therapy and tumour recurrence. Magnetic Resonance Imaging is a widely used imaging tool for canc...
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Article
Open AccessDiscovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica
Scopolia tangutica (S. tangutica) is a traditional Chinese medicinal plant used for antispasmodics, anesthesia, analgesia and sedation. Its pharmacological activities are mostly associated with the antagonistic a...
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Article
Open AccessAssociation between H-type Hypertension and Asymptomatic Extracranial Artery Stenosis
Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke and H-type hypertension, which is defined as hypertension with hyperhomocysteinemia, is associated with cardio-cerebrovas...
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Open AccessThree-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography
Scaffolded DNA origami has proven to be a powerful and efficient technique to fabricate functional nanomachines by programming the folding of a single-stranded DNA template strand into three-dimensional (3D) n...
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Open AccessAn Algorithm for Enhancing the Image Contrast of Electron Tomography
Three-dimensional (3D) reconstruction of a single protein molecule is essential for understanding the relationship between the structural dynamics and functions of the protein. Electron tomography (ET) provide...
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Open AccessPCA-PAM50 improves consistency between breast cancer intrinsic and clinical subty** reclassifying a subset of luminal A tumors as luminal B
The PAM50 classifier is widely used for breast tumor intrinsic subty** based on gene expression. Clinical subty**, however, is based on immunohistochemistry assays of 3–4 biomarkers. Subtype calls by these...
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Open AccessSingle-Molecule 3D Images of “Hole-Hole” IgG1 Homodimers by Individual-Particle Electron Tomography
The engineering of immunoglobulin-G molecules (IgGs) is of wide interest for improving therapeutics, for example by modulating the activity or multiplexing the specificity of IgGs to recognize more than one an...
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Open AccessThe integration of metabolome and proteome reveals bioactive polyphenols and hispidin in ARTP mutagenized Phellinus baumii
Phellinus baumii, also called “Sang Huang” in China, is broadly used as a kind of health food or folk medicine in Asia for its high biological activities, e.g. anti-tumor, anti-oxidation and anti-inflammatory act...
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Open AccessLoTToR: An Algorithm for Missing-Wedge Correction of the Low-Tilt Tomographic 3D Reconstruction of a Single-Molecule Structure
A single-molecule three-dimensional (3D) structure is essential for understanding the thermal vibrations and dynamics as well as the conformational changes during the chemical reaction of macromolecules. Indiv...
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Open AccessMutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia
The mutational spectrum and prognostic factors of NRAS-mutated (NRASmut) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovere...
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Open AccessIs the risk of second primary malignancy increased in multiple myeloma in the novel therapy era? A population-based, retrospective cohort study in Taiwan
Longer survival in patients with multiple myeloma (MM) after treatment with novel agents (NA) such as thalidomide, bortezomib, and lenalidomide may be associated with increased risks of develo** second prima...
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Open AccessTreatment pathways and disease journeys differ before and after introduction of novel agents in newly diagnosed multiple myeloma in Taiwan
Limited real-world data are available regarding treatment practices and outcomes of multiple myeloma (MM) in Asia. We conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Resea...
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Open AccessA comprehensive retrospective cohort study of the journey of B-cell lymphoma in Taiwan
Complete disease journey and risk factors for poor outcomes are needed to facilitate effectiveness evaluations of new therapies and clinical decision-making in B-cell Non-Hodgkin lymphoma (B-NHL), particularly...
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Open AccessDesigned and biologically active protein lattices
Versatile methods to organize proteins in space are required to enable complex biomaterials, engineered biomolecular scaffolds, cell-free biology, and hybrid nanoscale systems. Here, we demonstrate how the tai...
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Open AccessRetraction Note: HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development
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Open AccessMemory load differentially influences younger and older users’ learning curve of touchscreen gestures
In this study, we employed a recall test to investigate how memory load affects the learning curve of gesture-letter pairs for younger and older users. The gesture-letter pairs were carefully designed to mimic...
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Strong yet ductile nanolamellar high-entropy alloys by additive manufacturing
Additive manufacturing produces net-shaped components layer by layer for engineering applications1–7. The additive manufacture of metal alloys by laser powder bed fusion (L-PBF) involves large temperature gradien...
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Open AccessA population-based cohort study of the epidemiology of light-chain amyloidosis in Taiwan
The incidence rate of AL (light-chain) amyloidosis is not known in Asia. We conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Research database and Death Registry to estimat...