55 Result(s)
within
**an-Yan Zhao
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessA metasomatized mantle wedge origin for low-δ 18O olivine in late Cretaceous Junan and Qingdao basalts in the Sulu orogen
The North China Block (NCB) experienced extensive lithospheric thinning and subsequent mantle accretion in the Mesozoic to Cenozoic, but their mechanism remains controversial. This paper reports in situ chemical ...
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Open AccessHigh-Resolution Melting Analysis for accurate detection of BRAF mutations: a systematic review and meta-analysis
The high-resolution melting curve analysis (HRMA) might be a good alternative method for rapid detection of BRAF mutations. However, the accuracy of HRMA in detection of BRAF mutations has not been systematica...
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Experimental investigation on upstream-injection interaction with a scramjet cavity flameholder
The study has evaluated the coherent structures and the velocity field of gaseous transverse jet upstream of a scramjet flameholder in a supersonic turbulent flow. The high spatiotemporal resolution coherent s...
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Open AccessStiff substrates enhance cultured neuronal network activity
The mechanical property of extracellular matrix and cell-supporting substrates is known to modulate neuronal growth, differentiation, extension and branching. Here we show that substrate stiffness is an import...
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Open AccessUtilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality
High-quality protein crystals of suitable size are an important prerequisite for applying X-ray crystallography to determine the 3-dimensional structure of proteins. However, it is often difficult to obtain pr...
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Open AccessTransforming berberine into its intestine-absorbable form by the gut microbiota
The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on the interaction between intestinal bacteria and orally administered chemical drugs. Oral administration ...
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Open AccessGossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites
Of the two cultivated species of allopolyploid cotton, Gossypium barbadense produces extra-long fibers for the production of superior textiles. We sequenced its genome (AD)2 and performed a comparative analysis. ...
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Open AccessA CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma
Clear cell renal cell carcinomas (ccRCCs) display divergent clinical behaviours. Molecular markers might improve risk stratification of ccRCC. Here we use, based on genome-wide CpG methylation profiling, a LAS...
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Open AccessPyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
In cancer cells, the mammalian target of rapamycin complex 1 (mTORC1) that requires hormonal and nutrient signals for its activation, is constitutively activated. We found that overexpression of pyruvate kinas...
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Open AccessH18 Carbon: A New Metallic Phase with sp2-sp3 Hybridized Bonding Network
Design and synthesis of three-dimensional metallic carbons are currently one of the hot issues in contemporary condensed matter physics because of their fascinating properties. Here, based on first-principles ...
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Open AccessSeeking a geochemical identifier for authigenic carbonate
Authigenic carbonate was recently invoked as a third major global carbon sink in addition to primary marine carbonate and organic carbon. Distinguishing the two carbonate sinks is fundamental to our understand...
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Open AccessSurgery Combined with Radiotherapy Improved Survival in Metastatic Esophageal Cancer in a Surveillance Epidemiology and End Results Population-based Study
This retrospective study used a population-based national registry to determine the impact of local treatment modalities on survival in patients with metastatic esophageal cancer (EC). The Surveillance Epidemi...
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Open AccessOral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus
High salt intake leads to an increase in some proinflammatory cytokines and neurotransmitters involved in the pathogenesis of hypertension. The purpose of this work was to know if oral administration of anti-o...
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Open AccessMdHIR proteins repress anthocyanin accumulation by interacting with the MdJAZ2 protein to inhibit its degradation in apples
In higher plants, jasmonate ZIM-domain (JAZ) proteins negatively regulate the biosynthesis of anthocyanins by interacting with bHLH transcription factors. However, it is largely unknown if and how other regulator...
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Open AccessBilirubin augments Ca2+ load of develo** bushy neurons by targeting specific subtype of voltage-gated calcium channels
Neonatal brain is particularly vulnerable to pathological levels of bilirubin which elevates and overloads intracellular Ca2+, leading to neurotoxicity. However, how voltage-gated calcium channels (VGCCs) are fun...
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Open AccessSecurity of a kind of quantum secret sharing with entangled states
We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others’ co...
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Open AccessExo70 is an independent prognostic factor in colon cancer
Exo70, a key component of the Exocyst complex, plays important roles in human cancer progression beyond exocytosis. However, the expression of Exo70 and its prognostic value for patients with colon cancer has ...
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Open AccessSgRNA Expression of CRIPSR-Cas9 System Based on MiRNA Polycistrons as a Versatile Tool to Manipulate Multiple and Tissue-Specific Genome Editing
CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initia...
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Open AccessComparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis
To investigate the effects of age at diagnosis on metastatic breast cancer and patients’ prognosis, we collected patient data from the Surveillance, Epidemiology, and End Results (SEER) database. We finally id...
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Open AccessClinical symptoms and related risk factors in pulmonary embolism patients and cluster analysis based on these symptoms
Pulmonary embolism (PE) remains largely underdiagnosed due to nonspecific symptoms. This study aims to evaluate typical symptoms of PE patients, their related predictors, and to differentiate typical clusters ...
