69 Result(s)

Article

Lithium carbonate revitalizes tumor-reactive CD8⁺ T cells by shunting lactic acid into mitochondria

The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses antitumor T cell immunity. However, LA is a natural energy metaboli...

**gwei Ma, Liang Tang, Yaoyao Tan, **gxuan **ao, Keke Wei, **n Zhang… in Nature Immunology (2024)

Article

DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma

Lung cancer is a malignant tumor with the highest mortality worldwide. Abnormalities in the ubiquitin proteasome system are considered to be contributed to lung cancer progression with deleterious effects. DDB...

Shan Wei, **g **ng, Jia Chen, Li** Chen… in Journal of Experimental & Clinical Cancer … (2024)

Article

Correction: UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling

Jian-**an Lin, **n-Sheng **e… in Journal of Experimental & Clinical Cancer … (2023)

Article

RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling

Astrocytes contribute to chronic neuroinflammation in a variety of neurodegenerative diseases, including Parkinson's disease (PD), the most common movement disorder. However, the precise role of astrocytes in ...

Shu Yin, **n-yue Ma, Ying-feng Sun, Yan-qing Yin, Ying Long… in Journal of Neuroinflammation (2023)

Article

Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules

Ebola virus (EBOV) causes hemorrhagic fever in humans with high morbidity and fatality. Although over 45 years have passed since the first EBOV outbreak, small molecule drugs are not yet available. Ebola viral...

Yan-hong Ma, Xu Hong, Fang Wu, **n-feng Xu, Rui Li, ** Zhong… in Acta Pharmacologica Sinica (2023)

Article

Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails

The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses challenges to the effectiveness of neutralizing antibodies. Rational design of antibody cocktails is a re...

Hang Ma, Hui-fang Zong, Jun-jun Liu, Ya-li Yue, Yong Ke… in Acta Pharmacologica Sinica (2023)

Article

A lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis

CTLA4Ig is a dimeric fusion protein of the extracellular domain of cytotoxic T-lymphocyte protein 4 (CTLA4) and an Fc (Ig) fragment of human IgG₁ that is approved for treating rheumatoid arthritis. However, CTLA4...

Fu-Yao Jiang, Yan-Zhu Zhang, Yuan-Hong Tai, Chien-Yu Chou… in Inflammation and Regeneration (2023)

Article

Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases

Dysregulated activation of the inflammasome is involved in various human diseases including acute cerebral ischemia, multiple sclerosis and sepsis. Though many inflammasome inhibitors targeting NOD-like recept...

Chen Chen, YuWei Zhou, **nPeng Ning, ShengLong Li… in Journal of Neuroinflammation (2022)

Article

Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...

Fang Fang, Jun Lu, Xu Sang, Yan-Fang Tao… in Journal of Experimental & Clinical Cancer … (2022)

Article

Long noncoding RNA LINC00930 promotes PFKFB3-mediated tumor glycolysis and cell proliferation in nasopharyngeal carcinoma

Metabolic reprogramming is a hallmark of cancer. However, the roles of long noncoding RNAs (lncRNAs) in cancer metabolism, especially glucose metabolism remain largely unknown.

Baoyu He, Hongli Pan, Fengque Zheng… in Journal of Experimental & Clinical Cancer … (2022)

Article

HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer

Most cancer cells have fundamentally different metabolic characteristics, particularly much higher glycolysis rates than normal tissues, which support the increased demand for biosynthesis and promote tumor pr...

Yiwei Huang, Zhencong Chen, Tao Lu… in Journal of Experimental & Clinical Cancer … (2021)

Article

Retraction Note: TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways

Run-Wei Yang, Ying-Yue Zeng, Wen-Ting Wei… in Journal of Experimental & Clinical Cancer … (2021)

Article

A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation

Liver cancer stem cells (LCSCs) play key roles in the metastasis, recurrence, and chemotherapeutic resistance of hepatocellular carcinoma (HCC). Our previous research showed that the POSTN gene is closely related...

Gang Chen, Yi Wang, **n Zhao, **ao-zai **e… in Journal of Experimental & Clinical Cancer … (2021)

Article

Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients

Serological tests play an essential role in monitoring and combating the COVID-19 pandemic. Recombinant spike protein (S protein), especially the S1 protein, is one of the major reagents used for serological t...

Yang Li, Dan-yun Lai, Qing Lei, Zhao-wei Xu, Feng Wang… in Cellular & Molecular Immunology (2021)

Article

Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells

Glioma stem cells (GSCs) are considered the initial cells of gliomas, contributing to therapeutic resistance. Patient-derived GSCs well recapitulate the heterogeneity of their parent glioma tissues, which can ...

Zihang Chen, Huizhi Wang, Zongpu Zhang… in Journal of Experimental & Clinical Cancer … (2021)

Article

D-mannose ameliorates autoimmune phenotypes in mouse models of lupus

Systemic lupus erythematosus is an autoimmune disease characterized by an overproduction of autoantibodies resulting from dysregulation in multiple immune cell types. D-mannose is a C^− 2 epimer of glucose that ex...

Haiting Wang, **angyu Teng, Georges Abboud, Wei Li, Shuang Ye… in BMC Immunology (2021)

Article

Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice

The R1441G mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results in late-onset Parkinson’s disease (PD). Peripheral inflammation and gut microbiota are closely associated with the pathogenesis of P...

Yu-Kun Feng, Qiong-Li Wu, Yan-Wen Peng, Feng-Yin Liang… in Journal of Neuroinflammation (2020)

Article

Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are stil...

Yuhui Zhang, Weibin Huang, Yujie Yuan… in Journal of Experimental & Clinical Cancer … (2020)

Article

Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis

Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune astrocytopathic disease associated with the anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions primarily located on t...

Ye Gong, Ya-ling Zhang, Zhen Wang, Huan-huan Song… in Journal of Neuroinflammation (2020)

Article

JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis

Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and drug resistance. Tumor angiogenesis plays an ...

Jun-Jie Chen, Yan-Lin Ren, Chuan-Jun Shu… in Journal of Experimental & Clinical Cancer … (2020)