110 Result(s)

Article

Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma

Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links...

Fei Li, Wenzhe Si, Li **a, Deshan Yin, Tianjiao Wei, Ming Tao… in Molecular Cancer (2024)

Article

Comprehensive analysis of m6A modification in immune infiltration, metabolism and drug resistance in hepatocellular carcinoma

N6-methyladenosine (m6A) is important in regulating mRNA stability, splicing, and translation, and it also contributes to tumor development. However, there is still limited understanding of the comprehensive e...

Yunxing Shi, Kai Li, Yichuan Yuan, Chenwei Wang, Zhiwen Yang… in Cancer Cell International (2024)

Article

A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study

Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

Peng-chao Zhan, Shuo Yang, **ng Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang… in BMC Cancer (2024)

Article

Trajectories of neutrophil-to-lymphocyte ratios during neoadjuvant chemotherapy correlate with short- and long-term outcomes in gastric cancer: a group-based trajectory analysis

Systemic inflammatory factors can predict the survival prognosis of gastric cancer (GC) patients after neoadjuvant chemotherapy (NACT). However, whether longitudinal changes in systemic inflammatory factors ar...

Hua-Long Zheng, Fu-Hai Wang, Ling-Kang Zhang, ** Li, Chao-Hui Zheng… in BMC Cancer (2024)

Article

A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway

Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that circRNAs have been identified as pivotal media...

Bo Huang, Junwu Ren, Qiang Ma, Feifei Yang, **aojuan Pan, Yuying Zhang… in Molecular Cancer (2024)

Article

DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma

Lung cancer is a malignant tumor with the highest mortality worldwide. Abnormalities in the ubiquitin proteasome system are considered to be contributed to lung cancer progression with deleterious effects. DDB...

Shan Wei, **g **ng, Jia Chen, Li** Chen… in Journal of Experimental & Clinical Cancer … (2024)

Article

Appropriate dose of regorafenib based on body weight of colorectal cancer patients: a retrospective cohort study

Previous randomized studies have shown a survival benefit of using regorafenib but a high rate of adverse events in unresectable colorectal cancer patients. To reduce these adverse events and improve the toler...

Masayuki Nakashima, Kan Li, Qichen Chen, Sajith de Silva, Hal Li… in BMC Cancer (2023)

Article

Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients

Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit f...

Kong-Ying Lin, Qing-**g Chen, Shi-Chuan Tang, Zhi-Wen Lin, Jian-** Zhang… in BMC Cancer (2023)

Article

Correction: UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling

Jian-**an Lin, **n-Sheng **e… in Journal of Experimental & Clinical Cancer … (2023)

Article

CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling

Chemoresistance is a major clinical challenge that leads to tumor metastasis and poor clinical outcome. The mechanisms underlying gastric cancer resistance to chemotherapy are still unclear.

Long-Long Cao, Yu-Kai Wu, Tong-**n Lin, Mi Lin, Yu-**g Chen… in Cancer Cell International (2023)

Article

Evaluation of dynamic recurrence risk for locally advanced gastric cancer in the clinical setting of adjuvant chemotherapy: a real-world study with IPTW-based conditional recurrence analysis

The long-term dynamic recurrence hazard of locally advanced gastric cancer (LAGC) in the clinical setting of adjuvant chemotherapy (ACT) remains unclear.

Dong Wu, Jun Lu, Zhen Xue, Qing Zhong, Bin-bin Xu, Hua-Long Zheng… in BMC Cancer (2023)

Article

Risk of temporal lobe necrosis between proton beam and volumetric modulated arc therapies in patients with different head and neck cancers

To investigate the frequency of temporal lobe necrosis (TLN) soon after radiotherapy (RT) and identify differences among patients with various types of head and neck cancer (HNC) and between different RT methods.

Chi-Hung Liu, Chien-Yu Lin, Bing-Shen Huang, Yi-Chia Wei… in Radiation Oncology (2023)

Article

Value of biplane transrectal ultrasonography plus micro-flow imaging in preoperative T staging and rectal cancer diagnosis in combination with CEA/CA199 and MRI

Rectal cancer is one of the most common malignant tumors and has a high incidence rate and fatality rate. Accurate preoperative T staging of rectal cancer is critical for the selection of appropriate rectal ca...

Qin **a, Wei Cheng, Jie Bi, An-** Ren, **ao Chen, Tao Li in BMC Cancer (2023)

Article

Integrated models of blood protein and metabolite enhance the diagnostic accuracy for Non-Small Cell Lung Cancer

For early screening and diagnosis of non-small cell lung cancer (NSCLC), a robust model based on plasma proteomics and metabolomics is required for accurate and accessible non-invasive detection. Here we aim t...

Runhao Xu, Jiongran Wang, Qingqing Zhu, Chen Zou, Zehao Wei, Hao Wang… in Biomarker Research (2023)

Article

The safety of an MRI simulation-guided boost after short-course preoperative radiotherapy for unresectable rectal cancer (SUNRISE): interim analysis of a randomized phase II trial

The safety of an MRI simulation-guided boost after short-course preoperative radiotherapy (SCPRT) for unresectable rectal cancer is assessed with a planned interim analysis.

Wen-Yang Liu, **-Ming Shi, Ning Li, **n Wang, Yuan-Hong Gao… in Radiation Oncology (2022)

Article

Exosomal LINC00460/miR-503-5p/ANLN positive feedback loop aggravates pancreatic cancer progression through regulating T cell–mediated cytotoxicity and PD-1 checkpoint

Long non-coding RNA (lncRNA) LINC00460 is an onco-lncRNA in a variety of cancers, including pancreatic cancer (PC). This study is aimed to investigate the regulatory mechanisms of LINC00460 in PC.

Jun Yao, Ruoyu Gao, Minghan Luo, Defeng Li, Liliangzi Guo… in Cancer Cell International (2022)

Article

METTL1 promotes neuroblastoma development through m⁷G tRNA modification and selective oncogenic gene translation

Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high risk for rapid and fatal progression. Despite existing therapy approach...

Ying Huang, Jieyi Ma, Cuiyun Yang, Paijia Wei, Minghui Yang, Hui Han… in Biomarker Research (2022)

Article

Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...

Fang Fang, Jun Lu, Xu Sang, Yan-Fang Tao… in Journal of Experimental & Clinical Cancer … (2022)

Article

Decreased INPP5B expression predicts poor prognosis in lung adenocarcinoma

Inositol Polyphosphate-5-Phosphatase B (INPP5B), a inositol 5-phosphatase, plays an important role in many biological processes through phosphorylating PI(4,5)P₂ and/or PI(3,4,5)P₃ at the 5-position. Nevertheless...

Jun Deng, Xu Lin, Qi Li, **ao-yu Cai, Lin-wen Wu, Wei Wang… in Cancer Cell International (2022)

Article

Long noncoding RNA LINC00930 promotes PFKFB3-mediated tumor glycolysis and cell proliferation in nasopharyngeal carcinoma

Metabolic reprogramming is a hallmark of cancer. However, the roles of long noncoding RNAs (lncRNAs) in cancer metabolism, especially glucose metabolism remain largely unknown.

Baoyu He, Hongli Pan, Fengque Zheng… in Journal of Experimental & Clinical Cancer … (2022)