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Article

Expression, Activity, and Function of Phosphodiesterases in the Mature and Immature Ductus Arteriosus

A patent ductus arteriosus is due in large part to increased sensitivity of the premature ductus to PGE2. After PGE2 stimulation, cAMP concentrations are higher in the immature than in the mature ductus. cAMP ...

Hanguan Liu, Vincent Manganiello, Nahid Waleh, Ronald I Clyman in Pediatric Research (2008)