50 Result(s)
within
**-xin Gong
Neurosciences
-
Article
Association between obstructive sleep apnea and low bone mass in adults: a systematic review and meta-analysis
This study aimed to synthesize existing evidence on the potential association between obstructive sleep apnea (OSA) and low bone mass in adults.
-
Article
Open AccessA novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with a strong genetic liability. Despite extensive studies, however, the underlying pathogenic mechanism still remains elusive. In the ...
-
Article
Dysregulation of Circulatory Levels of lncRNAs in Parkinson’s Disease
Emerging evidence suggested that long non-coding RNAs (lncRNAs) were involved in Parkinson’s disease (PD) pathogenesis. Herein, we used gene expression profiles from GEO database to construct a PD-specific ceR...
-
Article
Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety
Anxiety-like behaviors in mice include social avoidance and avoidance of bright spaces. Whether these features are distinctly regulated is unclear. We demonstrate that in mice, social and anxiogenic stimuli, r...
-
Article
Open AccessTau seeding activity in various regions of down syndrome brain assessed by two novel assays
Propagation of tau pathology via the seeding of naive tau aggregation underlies the progression of Alzheimer’s disease (AD) and related tauopathies. Individuals with Down syndrome (DS) develop tau pathology at...
-
Article
Open AccessReduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...
-
Article
Open AccessDoes proteopathic tau propagate trans-synaptically in the brain?
-
Article
Open AccessEfficacy and practice of facemask use in general population: a systematic review and meta-analysis
In recent decades, respiratory infections, including SARS, HINI and the currently spreading COVID-19, caused by various viruses such as influenza and coronavirus have seriously threatened human health. It has ...
-
Article
A systematic review and meta-analysis on the prevalence of stigma in infectious diseases, including COVID-19: a call to action
Infectious diseases, including COVID-19, are crucial public health issues and may lead to considerable fear among the general public and stigmatization of, and discrimination against, specific populations. Thi...
-
Article
Open AccessDisrupted intrinsic functional brain topology in patients with major depressive disorder
Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, w...
-
Article
Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: a meta-analysis and systematic review
Pandemics have become more frequent and more complex during the twenty-first century. Posttraumatic stress disorder (PTSD) following pandemics is a significant public health concern. We sought to provide a rel...
-
Article
Open AccessAlzheimer’s disease brain contains tau fractions with differential prion-like activities
Neurofibrillary tangles (NFTs) made of abnormally hyperphosphorylated tau are a hallmark of Alzheimer’s disease (AD) and related tauopathies. Regional distribution of NFTs is associated with the progression of...
-
Article
Patterns of intrinsic brain activity in essential tremor with resting tremor and tremor-dominant Parkinson’s disease
The clinical pictures of essential tremor (ET) with resting tremor (rET) and tremor-dominant Parkinson’s disease (tPD) are often quite mimic at the early stage, current approaches to the diagnosis and treatmen...
-
Article
Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice
Recent pre-clinical and clinical studies suggest that general anesthesia in infants and children may increase the risk of learning disabilities. Currently, there is no treatment for preventing anesthesia-induc...
-
Article
Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic indivi...
-
Article
Open AccessYoung blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice
Recent studies indicated that circulatory factors in blood plasma from young animals can reactivate neurogenesis, restore synaptic plasticity, and improve cognitive function in aged animals. Here, we investiga...
-
Article
Antibody responses to SARS-CoV-2 in patients with COVID-19
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG...
-
Article
Pathological Alterations of Tau in Alzheimer’s Disease and 3xTg-AD Mouse Brains
Microtubule-associated protein tau in Alzheimer’s disease (AD) brain is hyperphosphorylated, truncated, and aggregated into neurofibrillary tangles. Oligomeric and hyperphosphorylated tau (Oligo-tau) isolated ...
-
Chapter
Molecular Connection Between Diabetes and Dementia
Type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) are both serious global health problems with high prevalence. These two diseases have some common features, including risk factors, age-associated d...
-
Article
Wang et al. reply
