10 Result(s)

Article

Tau exon 10 alternative splicing and tauopathies

Abnormalities of microtubule-associated protein tau play a central role in neurofibrillary degeneration in several neurodegenerative disorders that collectively called tauopathies. Six isoforms of tau are expr...

Fei Liu, Cheng-**n Gong in Molecular Neurodegeneration (2008)

Article

Poly (ADP-Ribose) Transferase/Polymerase-1-Deficient Mice Resistant to Age-Dependent Decrease in β-Cell Proliferation

Basal and adaptive β-cell regeneration capacity declines with old age, but the underlying molecular mechanisms remain incompletely understood. Poly (adenosine diphosphate [ADP]-ribose) polymerase 1 (PARP-1) is...

Lei Gong, Fu-qiang Liu, Ying Wang, **n-guo Hou, Wei Zhang… in Molecular Medicine (2012)

Article

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmarks of Alzheimer’s disease (AD). Increasing the quantity of the O-linked N-acetylglucosamine (O-GlcNAc) post-translational mo...

Scott A Yuzwa, **aoyang Shan, Bryan A Jones, Gang Zhao… in Molecular Neurodegeneration (2014)

Article

Fabrication of Continuous Microfibers Containing Magnetic Nanoparticles by a Facile Magneto-Mechanical Drawing

A facile method termed magneto-mechanical drawing is used to produce polymer composite microfibers. Compared with electrospinning and other fiber spinning methods, magneto-mechanical drawing uses magnetic forc...

**-Tao Li, **an-Sheng Jia, Gui-Feng Yu, Xu Yan, **ao-**ao He… in Nanoscale Research Letters (2016)

Article

Correction: Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

Nat. Med. 23, 439–449 (2017); published online 20 February 2017; corrected after print 26 July 2017 In the version of this article initially published, the authors inadvertently left out information in the Onl...

Pi-**ao Wang, Yan-**ao Ji, **ao-**g Zhang, Ling-** Zhao… in Nature Medicine (2017)

Article

RIPK4 promotes bladder urothelial carcinoma cell aggressiveness by upregulating VEGF-A through the NF-κB pathway

Constitutively activated nuclear factor kappa B (NF-κB) signalling plays vital roles in bladder urothelial carcinoma (BC) progression. We investigate the effect of receptor-interacting protein kinase 4 (RIPK4)...

Jian-Ye Liu, Qing-Hai Zeng, Pei-Guo Cao, Dan **e, **n Chen… in British Journal of Cancer (2018)

Article

Antibody responses to SARS-CoV-2 in patients with COVID-19

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG...

Quan-**n Long, Bai-Zhong Liu, Hai-Jun Deng, Gui-Cheng Wu, Kun Deng… in Nature Medicine (2020)

Article

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic indivi...

Quan-**n Long, **ao-Jun Tang, Qiu-Lin Shi, Qin Li, Hai-Jun Deng… in Nature Medicine (2020)

Article

Does proteopathic tau propagate trans-synaptically in the brain?

Wen Hu, Fei Liu, Cheng-**n Gong, Khalid Iqbal in Molecular Neurodegeneration (2022)

Article

Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells

Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling diseases. Recently, it has been discovered that tRNA-derived small RNAs (tsRNAs), a new type of noncoding RNAs,...

Jian-Zhi Zhao, Qi-Yao Li, Jia-Jie Lin, Li-Yun Yang… in Cellular & Molecular Biology Letters (2022)