30 Result(s)

Article

The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients

Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown ...

Chia-Jui Hsu, Lee Chin Wong, Hsin-Pei Wang… in Journal of Neurodevelopmental Disorders (2023)

Article

Integrated proteogenomic characterization reveals an imbalanced hepatocellular carcinoma microenvironment after incomplete radiofrequency ablation

Efforts to precisely assess tumor-specific T-cell immune responses still face major challenges, and the potential molecular mechanisms mediating hepatocellular carcinoma (HCC) microenvironment imbalance after ...

Zheng-Rong Shi, Yu-**n Duan, Fang Cui… in Journal of Experimental & Clinical Cancer … (2023)

Article

Repurposing nitric oxide donating drugs in cancer therapy through immune modulation

Nitric oxide-releasing drugs are used for cardiovascular diseases; however, their effects on the tumor immune microenvironment are less clear. Therefore, this study explored the impact of nitric oxide donors o...

Chung-Yen Li, Gangga Anuraga… in Journal of Experimental & Clinical Cancer … (2023)

Article

An integrated biometric voice and facial features for early detection of Parkinson’s disease

Hypomimia and voice changes are soft signs preceding classical motor disability in patients with Parkinson’s disease (PD). We aim to investigate whether an analysis of acoustic and facial expressions with mach...

Wee Shin Lim, Shu-I Chiu, Meng-Ciao Wu, Shu-Fen Tsai, Pu-He Wang… in npj Parkinson's Disease (2022)

Article

PDCD5 inhibits progression of renal cell carcinoma by promoting T cell immunity: with the involvement of the HDAC3/microRNA-195-5p/SGK1

Epigenetics exerts a vital role in the onset and development of renal cell carcinoma (RCC). Mounting evidence has shed light on the significance of human immune system in response to tumor infiltrating T cells...

Shu-cheng Liu, Li-bo Chen, **-feng Chen, Meng-long Huang… in Clinical Epigenetics (2022)

Article

An immunodominant NP_105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

NP_105–113-B*07:02-specific CD8⁺ T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP_105–113-B*...

Yanchun Peng, Suet Ling Felce, Danning Dong, Frank Penkava… in Nature Immunology (2022)

Article

Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation

Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are commonly used new-generation drugs for depression. Depressive symptoms are thought to be closely rel...

Jia-Hui He, Rong-Pei Liu, Yi-Man Peng, Qing Guo… in Journal of Neuroinflammation (2021)

Article

Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice

The R1441G mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results in late-onset Parkinson’s disease (PD). Peripheral inflammation and gut microbiota are closely associated with the pathogenesis of P...

Yu-Kun Feng, Qiong-Li Wu, Yan-Wen Peng, Feng-Yin Liang… in Journal of Neuroinflammation (2020)

Article

Broad and strong memory CD4⁺ and CD8⁺ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery...

Yanchun Peng, Alexander J. Mentzer, Guihai Liu, Xuan Yao, Zixi Yin… in Nature Immunology (2020)

Article

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

Neuroinflammation plays a vital role in early brain injury (EBI) following subarachnoid hemorrhage (SAH). The hypothesis of this study was that activation of melanocortin 1 receptor (MC1R) with BMS-470539 atte...

Weilin Xu, Jun Mo, Umut Ocak, Zachary D. Travis, Budbazar Enkhjargal… in Neurotherapeutics (2020)

Article

The prolonged interval between induction chemotherapy and radiotherapy is associated with poor prognosis in patients with nasopharyngeal carcinoma

Induction chemotherapy (IC) now is gaining recognition for the treatment of nasopharyngeal carcinoma (NPC). The current study was conducted to examine the association between prognosis and the interval between...

Liang Peng, **-Qi Liu, Cheng Xu, **ao-Dan Huang, Ling-Long Tang… in Radiation Oncology (2019)

Article

Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner

Antiangiogenic agents are commonly used in lung and colon cancer treatments, however, rapid development of drug resistance limits their efficacy.

Shengming Deng, Guoxi Zhang, Jiajie Kuai… in Journal of Experimental & Clinical Cancer … (2018)

Article

Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma

Renal cell carcinoma (RCC) account for over 80% of renal malignancies. The most common type of RCC can be classified into three subtypes including clear cell, papillary and chromophobe. ccRCC (the Clear Cell R...

Peng Wu, Jia-Li Liu, Shi-Mei Pei, Chang-Peng Wu, Kai Yang, Shu-Peng Wang… in BMC Cancer (2018)

Article

HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury

Hydroxysafflor yellow A (HSYA) is a major active component of yellow pigment extracted from safflowers; this compound possesses potent neuroprotective effects both in vitro and in vivo. However, underlying mec...

Jun-peng Pei, Li-hong Fan, Kai Nan, Jia Li, **ao-qian Dang… in Journal of Neuroinflammation (2017)

Article

Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC)

Nantanit Sutthiruk, Mari Botti… in Antimicrobial Resistance & Infection Contr… (2017)

Article

Preclinical PK/PD model for combined administration of erlotinib and sunitinib in the treatment of A549 human NSCLC xenograft mice

Combined therapy of EGFR TKI and VEGFR TKI may produce a greater therapeutic benefit and overcome EGFR TKI-induced resistance. However, a previous study shows that a combination of EGFR TKI erlotinib (ER) with...

**g-yun Li, Yu-peng Ren, Yin Yuan, Shuang-min Ji… in Acta Pharmacologica Sinica (2016)

Article

RETRACTED ARTICLE: Targeted DNA methylation analysis explores association of adenocarcinoma and neuroendocrine epitypes with lung cancer

Qing-Sheng Zhao, Ling-Ling Hu, Peng Tian, Zhi-Dong Wang, Zhao-Pei Li… in Tumor Biology (2016)

Article

MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets

Increasing evidence indicates that Epithelial–mesenchymal transition (EMT) can be regulated by microRNAs (miRNAs). MiR-449a is a liver abundant miRNA. However, the role of miR-449a in the metastasis of hepatoc...

Shu-peng Chen, Bao-xin Liu, Jie Xu, **ao-feng Pei, Yi-ji Liao, Feng Yuan… in BMC Cancer (2015)

Article

Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lnc...

Ming-De Huang, Wen-Ming Chen, Fu-Zhen Qi, Ming Sun, Tong-Peng Xu… in Molecular Cancer (2015)

Article

Sanguinarine inhibits Rac1b-rendered cell survival enhancement by promoting apoptosis and blocking proliferation

Small GTPase Rac1 is a member of the Ras superfamily, which plays important roles in regulation of cytoskeleton reorganization, cell growth, proliferation, migration, etc. The aim of this study was to determine h...

Li Ying, Gang Li, Si-si Wei, Hong Wang, Pei An, Xun Wang… in Acta Pharmacologica Sinica (2015)