2,449 Result(s)
within
**-li Lu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessDynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
Adipose tissue plays critical roles in an individual’s aging process. In this research, we use single-nucleus RNA sequencing to create highly detailed transcriptional maps of subcutaneous adipose tissue and vi...
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Open AccessGlutamate acts on acid-sensing ion channels to worsen ischaemic brain injury
Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-d-aspartate receptor)-dependent cell death pathways in stroke1,2, but unsuccessful clinical trials with NMDAR antagonists impli...
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Open AccessTranscriptome sequencing of garlic reveals key genes related to the heat stress response
With global warming, heat stress has become an important factor that seriously affects crop yield and quality. Therefore, understanding plant responses to heat stress is important for agricultural practice, bu...
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Open AccessL-shaped association between serum chloride levels with 90-day and 365-day all-cause mortality in critically ill patients with COPD: a retrospective cohort study
This study aimed to investigate the association between serum chloride levels and all-cause mortality in critically ill patients with chronic obstructive pulmonary disease (COPD). Data from the Medical Informa...
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Open AccessAssessing land-use changes and carbon storage: a case study of the Jialing River Basin, China
Land-use change is the main driver of carbon storage change in terrestrial ecosystems. Currently, domestic and international studies mainly focus on the impact of carbon storage changes on climate, while studi...
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Open AccessPopulation structure and antibiotic resistance of swine extraintestinal pathogenic Escherichia coli from China
Extraintestinal Pathogenic Escherichia coli (ExPEC) pose a significant threat to human and animal health. However, the diversity and antibiotic resistance of animal ExPEC, and their connection to human infections...
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Open AccessPerformance of Microsoft Azure Kinect DK as a tool for estimating human body segment lengths
The Microsoft Kinect depth sensor, with its built-in software that automatically captures joint coordinates without markers, could be a potential tool for ergonomic studies. This study investigates the perform...
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Open AccessDifferent clinicopathological features between young and older patients with pulmonary adenocarcinoma and ground-glass opacity
After the recommendation of computed tomography as a routine procedure for lung cancer screening, an increasing number of young adults have been diagnosed with pulmonary ground-glass opacity (GGO). Up to 63% o...
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Open AccessObservation of stacking engineered magnetic phase transitions within moiré supercells of twisted van der Waals magnets
Recent demonstrations of moiré magnetism, featuring exotic phases with noncollinear spin order in the twisted van der Waals (vdW) magnet chromium triiodide CrI3, have highlighted the potential of twist engineerin...
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Open AccessHematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery
Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs...
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Open AccessATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells
Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...
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Open AccessInfluence of thickness and strength on plastic instability in tailored steel structures
A mathematical model was intricately devised to explore the influence of continuous variations in thickness and mechanical properties on the performance of tailor rolled blanks (TRB) and tailor rolled tubes (T...
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Open AccessAuthor Correction: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
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Open AccessThree SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective
As the new SARS-CoV-2 Omicron variants and subvariants emerge, there is an urgency to develop intranasal, broadly protective vaccines. Here, we developed highly efficacious, intranasal trivalent SARS-CoV-2 vac...
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Open AccessSpeculative culture and corporate high-quality development in China: mediating effect of corporate innovation
This paper associates the speculative culture with the corporate total factor productivity (TFP), aiming to explore the influence of speculative culture on corporate high-quality development. The results revea...
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Open AccessNBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically1,2. This results in substantial accumulation of lacate, the end...
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Open AccessBiparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCS...
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Open AccessZona incerta mediates early life isoflurane-induced fear memory deficits
The potential long-term effects of anesthesia on cognitive development, especially in neonates and infants, have raised concerns. However, our understanding of its underlying mechanisms and effective treatment...
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Tunable superconductivity in electron- and hole-doped Bernal bilayer graphene
Graphene-based, high-quality, two-dimensional electronic systems have emerged as a highly tunable platform for studying superconductivity1–21. Specifically, superconductivity has been observed in both electron- a...
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Open AccessCRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-...
