137 Result(s)
-
Article
Humanin peptide suppresses apoptosis by interfering with Bax activation
Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases1. Bax resides in an inactive state in the cytosol of many cells. ...
-
Article
Open AccessWalkable Dual Emissions
Walkable dual emissions, in which the emission bands of the walker reversibly cross or leave those of the stationary ones depending on temperature and concentration, have been demonstrated in cyclic dimeric la...
-
Article
Open AccessCadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site
The heavy metal cadmium is a non-degradable pollutant. By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G...
-
Article
Open AccessAkt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency
Although PTEN/Akt signaling is frequently deregulated in human gastric cancers, the in vivo causal link between its dysregulation and gastric tumorigenesis has not been established. Here we show that inactivation...
-
Article
Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus
Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to...
-
Article
Open AccessA Promising New Class of High-Temperature Alloys: Eutectic High-Entropy Alloys
High-entropy alloys (HEAs) can have either high strength or high ductility and a simultaneous achievement of both still constitutes a tough challenge. The inferior castability and compositional segregation of ...
-
Article
Open AccessRegulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection
T cell functional exhaustion during chronic hepatitis B virus (HBV) infection may contribute to the failed viral clearance; however, the underlying molecular mechanisms remain largely unknown. Here we demonstr...
-
Article
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine map** of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the ‘i...
-
Article
Open AccessCassava genome from a wild ancestor to cultivated varieties
Cassava is a major tropical food crop in the Euphorbiaceae family that has high carbohydrate production potential and adaptability to diverse environments. Here we present the draft genome sequences of a wild ...
-
Article
Open AccessComparative characterization of two intracellular Ca2+-release channels from the red flour beetle, Tribolium castaneum
Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are members of a family of tetrameric intracellular Ca2+-release channels (CRCs). While it is well known in mammals that RyRs and IP3R...
-
Article
Open AccessThe complex jujube genome provides insights into fruit tree biology
The jujube (Ziziphus jujuba Mill.), a member of family Rhamnaceae, is a major dry fruit and a traditional herbal medicine for more than one billion people. Here we present a high-quality sequence for the complex ...
-
Article
Open AccessReversible switching of magnetic states by electric fields in nitrogenized-divacancies graphene decorated by tungsten atoms
Magnetic graphene-based materials have shown great potential for develo** high-performance electronic devices at sub-nanometer such as spintronic data storage units. However, a significant reduction of power...
-
Article
Open AccessPrevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012
The epidemiology and clinical features of the Saffold cardiovirus (SAFV) remain ambiguous. The present study was designed to systematically and intensively investigate the epidemiological features of SAFV in p...
-
Article
Open AccessSurface Enhanced Electrochemiluminescence of Ru(bpy)32+
Surface enhanced spectroscopy such as surface enhanced Raman spectrum (SERS) and surface enhanced fluorescence have been investigated extensively in the past two decades. Herein, we present experimental eviden...
-
Article
Correction: Corrigendum: Reversible switching of magnetic states by electric fields in nitrogenized-divacancies graphene decorated by tungsten atoms
Using molecular dynamics simulations, we investigated an integrated bio-nano interface consisting of a β-sheet protein stacked onto graphene. We found that the stacking assembly of the model protein on graphen...
-
Article
Open AccessCancer risk among patients with type 2 diabetes mellitus: a population-based prospective study in China
Evidence indicates an increased cancer risk among type 2 diabetes mellitus (T2DM) patients, yet studies in mainland China are scarce. Based on Diabetes Surveillance System linking to Cancer Surveillance System...
-
Article
Open AccessCharacterization of Three Tetrabromobisphenol-S Derivatives in Mollusks from Chinese Bohai Sea: A Strategy for Novel Brominated Contaminants Identification
Identification of novel brominated contaminants in the environment, especially the derivatives and byproducts of brominated flame retardants (BFRs), has become a wide concern because of their adverse effects o...
-
Article
Open AccessIdentification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis
The naturally occurring diazobenzofluorenes, kinamycins, fluostatins and lomaiviticins, possess highly oxygenated A-rings, via which the last forms a dimeric pharmacophore. However, neither the A-ring transfor...
-
Article
Open AccessRegulation of T cell function by microRNA-720
Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit a...
-
Article
A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa
Retinitis pigmentosa is a leading cause of inherited blindness, with no effective treatment currently available. Mutations primarily in genes expressed in rod photoreceptors lead to early rod death, followed b...
