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  1. No Access

    Article

    Application of Pseudo Amino Acid Composition for Predicting Protein Subcellular Location: Stochastic Signal Processing Approach

    The function of a protein is closely correlated with its subcellular location. With the success of human genome project and the rapid increase in the number of newly found protein sequences entering into data ...

    Yu-** Pan, Zhi-Zhou Zhang, Zong-Ming Guo, Guo-Yin Feng… in Journal of Protein Chemistry (2003)

  2. No Access

    Article

    St. John’s Wort Modulates the Toxicities and Pharmacokinetics of CPT-11 (Irinotecan) in Rats

    CPT-11 is a DNA topoisomerase I inhibitor for the therapy of colorectal cancer, whereas St. John’s Wort (Hypericum perforatum, SJW) is a widely used herbal anti-depressant. This study aimed to investigate the eff...

    Ze** Hu, **aoxia Yang, Paul Chi-Liu Ho, Eli Chan… in Pharmaceutical Research (2005)

  3. No Access

    Article

    Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins

    The multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphosphate (ATP)-binding cassette transporter family. Camptothecins (CPTs) have shown substantial anticancer activity against ...

    Quan Tian, **g Zhang, Theresa May Chin Tan, Eli Chan, Wei Duan… in Pharmaceutical Research (2005)

  4. No Access

    Article

    The role of Thr5 in human neuron growth inhibitory factor

    GIF, a member of the metallothionein (MT) family (assigned as MT3), is a neuron growth inhibitory factor that inhibits neuron outgrowth in Alzheimer’s disease. The conserved Thr5 is one of the main differences...

    Bin Cai, Qi Zheng, **n-Chen Teng, Dong Chen… in JBIC Journal of Biological Inorganic Chemi… (2006)

  5. No Access

    Article

    Effect of α-domain substitution on the structure, property and function of human neuronal growth inhibitory factor

    Human metallothionein-3 (hMT3), also named human neuronal growth inhibitory factor (hGIF), is attractive due to its distinct neuronal growth inhibitory activity, which is not shown by other human MT isoforms. ...

    Zhi-Chun Ding, Qi Zheng, Bin Cai, Wen-Hao Yu… in JBIC Journal of Biological Inorganic Chemi… (2007)

  6. No Access

    Article

    Detection of antibody to hepatitis delta virus in human serum by double antigen sandwich ELISA

    A simple rapid detection of antibody to hepatitis delta virus (anti-HDV) in human serum was developed by using double antigen sandwich ELISA. HDV gene fragment encoding HDAg was isolated from a Chinese patient...

    Li **e, De-zhuang Huang, Li-xiang He, Zhao-xia Luo, Yu-sen Zhou… in Virologica Sinica (2009)

  7. No Access

    Article

    Spatial Filtering Improves EMG Classification Accuracy Following Targeted Muscle Reinnervation

    The combination of targeted muscle reinnervation (TMR) and pattern classification of electromyography (EMG) has shown great promise for multifunctional myoelectric prosthesis control. In this study, we hypothe...

    He Huang, ** Zhou, Guanglin Li, Todd Kuiken in Annals of Biomedical Engineering (2009)

  8. No Access

    Article

    Important roles of the conserved linker-KKS in human neuronal growth inhibitory factor

    Metallothinein-3 (MT3), also named neuronal growth inhibitory factor (GIF), is attractive by its distinct neuronal growth inhibitory activity, which is not shared by other MT isoforms. The polypeptide chain of...

    Zhi-Chun Ding, **n-Chen Teng, Qi Zheng, Feng-Yun Ni, Bin Cai, Yang Wang… in BioMetals (2009)

  9. No Access

    Article

    Histological Changes in Chinese Chronic Hepatitis B Patients with ALT Lower Than Two Times Upper Limits of Normal

    The role of ALT as a predictor of liver injury has been questioned. The aim of this study is to use liver biopsy to assess the degree of liver injury in patients with chronic hepatitis B(CHB) whose ALT < 2 × u...

    En-Qiang Chen, Fei-Jun Huang, Ling-Li He, Lang Bai… in Digestive Diseases and Sciences (2010)

  10. No Access

    Article

    An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for β-amyloid peptide as a monomer

    Aβ1–42 is the proteolytic cleavage product of cleavage of the amyloid precursor protein by β- and γ-secretases. The aggregation of Aβ1–42 plays a causative role in the development of Alzheimer’s disease. To lock ...

    Chunyi Jiang, Yu Feng, **aotong Huang, Yechun Xu… in Analytical and Bioanalytical Chemistry (2010)

  11. Article

    Open Access

    DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression

    When DNA double-strand breaks (DSB) are induced by ionizing radiation (IR) in cells, histone H2AX is quickly phosphorylated into γ-H2AX (p-S139) around the DSB site. The necessity of DNA-PKcs in regulating the...

    **g An, Yue-Cheng Huang, Qing-Zhi Xu, Li-Jun Zhou, Zeng-Fu Shang… in BMC Molecular Biology (2010)

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  12. No Access

    Article

    Enhanced biodesulfurization by magnetic immobilized Rhodococcus erythropolis LSSE8-1-vgb assembled with nano-γ-Al2O3

    Biodesulfurization activity can be enhanced by assembling nano-γ-Al2O3 particles on the magnetic immobilized Rhodococcus erythropolis LSSE8-1-vgb. The cells can be collected and reused conveniently by an external...

    Ting Zhang, Wang-Liang Li, **ao-**n Chen… in World Journal of Microbiology and Biotechn… (2011)

  13. No Access

    Article

    Advanced glycation end-products induce heparanase expression in endothelial cells by the receptor for advanced glycation end products and through activation of the FOXO4 transcription factor

    As an endo-β (1-4)-d-glucuronidase, heparanase can specifically cleave carbohydrate chains of heparan sulfate (HS) and has been implicated in development of endothelial cells dsyfunction. The advanced glycation e...

    **ao-Fei An, Lei Zhou, Peng-Jun Jiang, Ming Yan… in Molecular and Cellular Biochemistry (2011)

  14. No Access

    Article

    Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells

    The diperpenoid adenanthin covalently modifies the resolving cysteine from peroxiredoxins to inhibit the reduction of hydrogen peroxide, a second messenger in cells, and thereby activates pathways that promote...

    Chuan-Xu Liu, Qian-Qian Yin, Hu-Chen Zhou, Ying-Li Wu… in Nature Chemical Biology (2012)

  15. No Access

    Article

    Different Expression of S100A8 in Malignant and Benign Gallbladder Diseases

    Proteomic analysis is a powerful tool for complete establishment of protein expression. Comparative proteomic analysis of human bile from malignant and benign gallbladder diseases may be helpful in research in...

    Wei Wang, Kai-**ng Ai, Zhou Yuan, **n-Yu Huang… in Digestive Diseases and Sciences (2013)

  16. No Access

    Article

    Potential Prevention and Treatment of Maifanite for Alzheimer's Disease Based on Behavior Test, Oxidative Stress Assay, and Trace Element Analysis in Hippocampus of Aβ(25–35)-Induced AD Rats

    This study aimed to assess whether maifanite can improve the learning and memory, and antioxidant abilities of Alzheimer’s disease (AD) rats. The 70 rats were divided into seven groups: [A] normal control grou...

    Ling-Feng Jiang, Hai-Lin Liao, Hong-Miao Huang… in Biological Trace Element Research (2013)

  17. No Access

    Article

    Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

    TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell de...

    Wei-jia Wang, Yuan Wang, Hang-zi Chen, Yong-zhen **ng… in Nature Chemical Biology (2014)

  18. No Access

    Article

    Metabolomic profiling of three brain regions from a postnatal infected Borna disease virus Hu-H1 rat model

    Neonatal rat infection with Borna disease virus (BDV), termed neonatal Borna disease, is an established model for investigating the BDV-associated pathogenesis of neurodevelopmental abnormalities. BDV produces...

    Yang Lei, Dan Li, **g Deng, Wei-hua Shao, Song-hua Fan, **ao Wang… in Metabolomics (2014)

  19. No Access

    Article

    The Structure and Enzyme Characteristics of a Recombinant Leucine Aminopeptidase rLap1 from Aspergillus sojae and Its Application in Debittering

    A leucine aminopeptidase Lap1 was cloned from Aspergillus sojae GIM3.30. The truncated Lap1 without a signal peptide was over-expressed in P. pastoris, and the enzymatic characteristics of recombinant Lap1 (rLap1...

    Wei-Qian Huang, Li-Fen Zhong, Zhi-Zhong Meng… in Applied Biochemistry and Biotechnology (2015)

  20. No Access

    Article

    Fluorescent labeling for clonal selection of Marc 145 cells secreting high levels of recombinant protein PBD-1

    Despite the powerful impact gene expression markers like the green fluorescent protein (GFP) or enhanced GFP (EGFP) exert on linking the expression of recombinant protein for selection of high producers in rec...

    Hai-Jun Huang, **a Peng, Bing Deng, Cong Huang, Jie Li, Yun-Guo Qian… in Cytotechnology (2016)

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